ES2185725T3 - Derivados de benzotiazina sustituidos. - Google Patents
Derivados de benzotiazina sustituidos.Info
- Publication number
- ES2185725T3 ES2185725T3 ES96110050T ES96110050T ES2185725T3 ES 2185725 T3 ES2185725 T3 ES 2185725T3 ES 96110050 T ES96110050 T ES 96110050T ES 96110050 T ES96110050 T ES 96110050T ES 2185725 T3 ES2185725 T3 ES 2185725T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- similar
- rent
- perculation
- benzotiazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 abstract 2
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
- 108091005479 5-HT2 receptors Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 125000003258 trimethylene group Chemical class [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE PRESENTAN DERIVADOS DE BENZOTIAZINA SUSTITUIDA REPRESENTADOS POR LA SIGUIENTE FORMULA (I): EN DONDE LA LINEA ENTRE PARENTESIS INDICA LA PRESENCIA O AUSENCIA DE UN ENLACE; Z REPRESENTA UNO DE LOS SIGUIENTES GRUPOS: EN LOS CUALES R{SUB,1} Y R{SUB,2} INDIVIDUALMENTE REPRESENTAN ALQUILO, ARALQUILO O SIMILAR, R{SUB,3} REPRESENTA H, ALQUILO O SIMILAR, R{SUB,4} REPRESENTA H, ARALQUILO O SIMILAR, X{SUB,1}, X{SUB,2} Y X{SUB,3} INDIVIDUALMENTE REPRESENTAN 0 O S Y G REPRESENTA ETILENO SUSTITUIDO O NO SUSTITUIDO, TRIMETILENO O SIMILAR; Q{SUB,1} REPRESENTA H, OH, HALOGENO, ALCOXI O SIMILAR, Q{SUB,2} ES SIMILAR A Q{SUB,1} EXCEPTO POR LA EXCLUSION DE H; A REPRESENTA ALQUILENO, ALQUENILENO O SIMILAR; Y REPRESENTA CH, C= O N; CUANDO Y ES CH, M REPRESENTA 0 O 1, N REPRESENTA 1 O 2, B REPRESENTA O,S, CARBONILO O SIMILAR, CUANDO Y ES C=N, M REPRESENTA 1, N REPRESENTA 1 O 2, B REPRESENTA: EN EL CUAL EL DOBLE ENLACE ESTA UNIDO A Y, R{SUB,6} REPRESENTA ARILO SUSTITUIDO O NO O SIMILAR, CUANDO Y ES N, M REPRESENTA 0 O 1, N REPRESENTA 2 O 3, B REPRESENTA CARBONILO, SULFONILO O SIMILAR, E{SUB,1} Y E{SUB,2} INDIVIDUALMENTE REPRESENTA H O ALQUILO DE CADENA CORTA, Y D REPRESENTA UN GRUPO DE HIDROCARBURO AROMATICO O UN GRUPO HETEROCICLICO AROMATICO; Y SALES DE LOS MISMOS. LOS DERIVADOS DE BENZOTIAZINA SUSTITUIDA (I) Y SUS SALES DE ACUERDO CON LA PRESENTE INVENCION TIENEN FUERTE ACCION DE BLOQUEO DE SEROTONINA-2, TIENEN EXCELENTE SELECTIVIDAD PARA ESTA ACCION CONTRA ACCION DE BLOQUEO DE {AL}{SUB,1} Y TIENE ALTA SEGURIDAD. SEGUN LO DICHO, LA PRESENTE INVENCION HA HECHO ESO POSIBLE PARA SUMINISTRAR LA FABRICACION DE MEDICAMENTOS PARA EL USO DE ACCION ANTAGONISTICA CONTRA RECEPTORES DE SEROTONINA-2, POR EJEMPLO, TERAPEUTICOS PARA VARIAS ENFERMEDADES CIRCULATORIAS TAL COMO ENFERMEDADES DE CORAZON ISQUEMICO, PERTURBACIONES CEREBRO VASCULARES Y PERTURBACIONES CIRCULATORIAS PERIFERICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7177976A JPH0912562A (ja) | 1995-06-22 | 1995-06-22 | 置換ベンゾチアジン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2185725T3 true ES2185725T3 (es) | 2003-05-01 |
Family
ID=16040372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96110050T Expired - Lifetime ES2185725T3 (es) | 1995-06-22 | 1996-06-21 | Derivados de benzotiazina sustituidos. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0749967B1 (es) |
JP (1) | JPH0912562A (es) |
KR (1) | KR100436031B1 (es) |
AT (1) | ATE231498T1 (es) |
CA (1) | CA2179679A1 (es) |
DE (1) | DE69625856T2 (es) |
ES (1) | ES2185725T3 (es) |
HU (1) | HUP9601712A3 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2221191T3 (es) | 1997-09-05 | 2004-12-16 | Warner-Lambert Company Llc | Ciertos dioxidos de benzotiazina, antagonistas de endotelina y procedimientos para su preparacion. |
DE19746612A1 (de) | 1997-10-22 | 1999-04-29 | Basf Ag | 2-Substituierte 1,2-Benzisothiazol-Derivate, ihre Herstellung und Verwendung |
JP2020527133A (ja) | 2017-06-20 | 2020-09-03 | インブリア ファーマシューティカルズ, インコーポレイテッド | 心臓代謝の効率を高めるための組成物および方法 |
US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1302858B (es) * | 1962-09-21 | 1972-05-04 | ||
FR2662696A2 (fr) * | 1989-12-13 | 1991-12-06 | Rhone Poulenc Sante | Antagonistes de la serotonine, leur preparation et medicaments les contenant. |
GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
ATE246682T1 (de) * | 1993-12-24 | 2003-08-15 | Daiichi Suntory Pharma Co Ltd | Benzothiazinderivate |
-
1995
- 1995-06-22 JP JP7177976A patent/JPH0912562A/ja active Pending
-
1996
- 1996-06-21 CA CA002179679A patent/CA2179679A1/en not_active Abandoned
- 1996-06-21 EP EP96110050A patent/EP0749967B1/en not_active Expired - Lifetime
- 1996-06-21 AT AT96110050T patent/ATE231498T1/de not_active IP Right Cessation
- 1996-06-21 ES ES96110050T patent/ES2185725T3/es not_active Expired - Lifetime
- 1996-06-21 KR KR1019960022776A patent/KR100436031B1/ko not_active IP Right Cessation
- 1996-06-21 HU HU9601712A patent/HUP9601712A3/hu unknown
- 1996-06-21 DE DE69625856T patent/DE69625856T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR970001362A (ko) | 1997-01-24 |
ATE231498T1 (de) | 2003-02-15 |
HU9601712D0 (en) | 1996-08-28 |
JPH0912562A (ja) | 1997-01-14 |
EP0749967A1 (en) | 1996-12-27 |
KR100436031B1 (ko) | 2004-12-30 |
HUP9601712A3 (en) | 1999-03-29 |
CA2179679A1 (en) | 1996-12-23 |
HUP9601712A2 (en) | 1997-10-28 |
DE69625856D1 (de) | 2003-02-27 |
DE69625856T2 (de) | 2004-02-12 |
EP0749967B1 (en) | 2003-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2194314T3 (es) | Derivados de benzopirano sustituidos para el tratamiento de inflamaciones. | |
ES2157424T3 (es) | Esteres de acido 5-aminolevulinico como agentes fotosensibilizantes en fotoquimioterapia. | |
ES2032899T3 (es) | Agente cosmetico para aplicacion externa y su uso. | |
ES2058185T3 (es) | Derivados de camptotecina y procedimiento para su preparacion. | |
ECSP034444A (es) | Derivados de 4-amino-6-fenil-pirrolo(2,3-d)pirimidina | |
ES2161231T3 (es) | Compuestos heterociclicos como antagonistas de bradiquinina. | |
TR200000782T2 (tr) | Resorsinol türevleri. | |
ES2158622T3 (es) | Derivados de 1,3,8-triazaespiro(4,5)decan-4-ona-8-sustituidos. | |
ES2184070T3 (es) | Derivados de oximas sustituidas utiles como antagonistas de la neuroquinina. | |
ES2175161T3 (es) | Derivados de piperazina como antagonistas de taquiquinina. | |
ES2108023T3 (es) | Composiciones de polimerizacion de dcpd. | |
ES2169248T3 (es) | Compuestos aromaticos y composiciones farmaceuticas que los contienen. | |
ES2026669T3 (es) | Procedimiento para la preparacion y el uso terapeutico de los beta-d-fenil tioxilosidos. | |
PA8576001A1 (es) | "difenilazetidinonas sustituidas en anillo, procedimiento para su preparacion , medicamentos que comprenden estos compuestos y su uso". | |
UY27232A1 (es) | Nuevos compuestos de dihidropirimidina ciano substituidos y su uso para tratar padecimientos | |
ES2185725T3 (es) | Derivados de benzotiazina sustituidos. | |
GT199900011A (es) | Nuevos derivados del acido dihidroxihexanoico | |
ES2164366T3 (es) | Derivados de la distamicina acriloil sustituidos, procedimiento de fabricacion asociado y su utilizacion como agentes antitumorales y antivirales. | |
ES2171911T3 (es) | Poliaminas conformacionalmente restringidas y su uso como agentes antineoplasicos. | |
ES2058518T3 (es) | 2-amino-1,2,3,4-tetrahidronaftalenos sustituidos en el anillo. | |
AR020563A1 (es) | Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion | |
ES2179218T3 (es) | Derivados de pirroloacepina. | |
ES2064328T3 (es) | Indolilpropanoles, procedimiento para su fabricacion y su uso, asi como preparaciones que contienen los compuestos. | |
ES2029879T3 (es) | Procedimiento para producir derivados de aminas sustituidas. | |
ES2170956T3 (es) | Derivados 2-alquenilicos de acido ciclopentan(en)oico como agentes terapeuticos en el tratamiento de hipertension ocular. |