ES2177921T3 - Compuestos de 1,4-dihidropiridina como antagonistas de bradiquinina. - Google Patents

Compuestos de 1,4-dihidropiridina como antagonistas de bradiquinina.

Info

Publication number
ES2177921T3
ES2177921T3 ES97900401T ES97900401T ES2177921T3 ES 2177921 T3 ES2177921 T3 ES 2177921T3 ES 97900401 T ES97900401 T ES 97900401T ES 97900401 T ES97900401 T ES 97900401T ES 2177921 T3 ES2177921 T3 ES 2177921T3
Authority
ES
Spain
Prior art keywords
bradiquinine
compounds
octilo
sub
dihydropiridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97900401T
Other languages
English (en)
Inventor
Takafumi Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2177921T3 publication Critical patent/ES2177921T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I) Y A SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE A 1 Y A SUP,2 SON AMBOS HALO; X ES CO, S(O) 2 O S(O) - (CH 2 ) SUB,N DONDE EL ATOMO DE S ESTA UNIDO DIRECTAMENTE AL FENILO Y N ES 0, 1 O 2; Y R 1 ES 8 - AZABICICLO[3,2,1]OCTILO, QUINUCLIDILO, BICICLO[3.3.0]OCTILO, CICLOALQUILO C 3-10 , 2, 3, 5, 6 TETRAHIDRO - 4H - TIOPIRANILO O CICLOALQUIL C 3-6 ALQUILO C 1-4 , SUSTITUIDO OPCIONALMENTE POR ALQUILO C SUB ,1-4 , HIDROXILO, DIOXARANILO U OXO. LOS NUEVOS COMPUESTOS DE DIHIDROXIPIRIDINA DE LA PRESENTE INVENCION TIENEN EXCELENTE ACTIVIDAD ANTAGONISTA DE BRADIQUININA Y SON, POR TANTO, UTILES PARA EL TRATAMIENTO DE ALTERACIONES MEDICAS CAUSADAS POR LA BRADIQUININA, COMO LA INFLAMACION, ENFERMEDAD CARDIOVASCULAR, DOLOR, RESFRIADO COMUN, ALERGIAS, ASMA, PANCREATITIS, QUEMADURAS, INFECCIONES VIRALES, LESIONES EN LA CABEZA, TRAUMATISMO MULTIPLE O SIMILARES, EN MAMIFEROS, ESPECIALMENTE EN HUMANOS.
ES97900401T 1996-02-19 1997-01-27 Compuestos de 1,4-dihidropiridina como antagonistas de bradiquinina. Expired - Lifetime ES2177921T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9600132 1996-02-19

Publications (1)

Publication Number Publication Date
ES2177921T3 true ES2177921T3 (es) 2002-12-16

Family

ID=11004406

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97900401T Expired - Lifetime ES2177921T3 (es) 1996-02-19 1997-01-27 Compuestos de 1,4-dihidropiridina como antagonistas de bradiquinina.

Country Status (34)

Country Link
US (1) US6131226A (es)
EP (1) EP0882044B1 (es)
JP (1) JP3167335B2 (es)
KR (1) KR19990082678A (es)
CN (1) CN1211251A (es)
AR (1) AR005841A1 (es)
AT (1) ATE220676T1 (es)
AU (1) AU1396497A (es)
BG (1) BG102678A (es)
BR (1) BR9707568A (es)
CA (1) CA2245857C (es)
CO (1) CO4650041A1 (es)
CZ (1) CZ258698A3 (es)
DE (1) DE69714019T2 (es)
DK (1) DK0882044T3 (es)
ES (1) ES2177921T3 (es)
HN (1) HN1997000013A (es)
HR (1) HRP970094A2 (es)
HU (1) HUP9902810A3 (es)
ID (1) ID16434A (es)
IL (1) IL124867A0 (es)
IS (1) IS4783A (es)
MA (1) MA26419A1 (es)
NO (1) NO983776L (es)
NZ (1) NZ325455A (es)
OA (1) OA10712A (es)
PE (1) PE36298A1 (es)
PL (1) PL328514A1 (es)
PT (1) PT882044E (es)
SI (1) SI0882044T1 (es)
TN (1) TNSN97037A1 (es)
TR (1) TR199801593T2 (es)
WO (1) WO1997030048A1 (es)
ZA (1) ZA971357B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11106375A (ja) * 1997-08-18 1999-04-20 Pfizer Pharmaceut Inc ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
US6653313B2 (en) * 2000-08-10 2003-11-25 Warner-Lambert Company Llc 1,4-dihydropyridine compounds as bradykinin antagonists
GB0427281D0 (en) * 2004-12-14 2005-01-12 3M Innovative Properties Co Methods of providing medicinal metal components having through holes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5120750A (en) * 1989-01-17 1992-06-09 Synphar Laboratories, Inc. Generation of 1,4-dihydropyridine derivatives
WO1996006083A1 (en) * 1994-08-24 1996-02-29 Pfizer Pharmaceuticals Inc. 2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines as bradykinin antagonists
MX9701245A (es) * 1996-02-19 1998-04-30 Pfizer Compuestos de 1,4 dihidropiridina.

Also Published As

Publication number Publication date
EP0882044B1 (en) 2002-07-17
JPH11507949A (ja) 1999-07-13
SI0882044T1 (en) 2002-10-31
PE36298A1 (es) 1998-07-18
IL124867A0 (en) 1999-01-26
NO983776D0 (no) 1998-08-18
HUP9902810A2 (hu) 2000-05-28
TNSN97037A1 (fr) 2005-03-15
DK0882044T3 (da) 2002-09-02
JP3167335B2 (ja) 2001-05-21
NZ325455A (en) 1999-07-29
KR19990082678A (ko) 1999-11-25
EP0882044A1 (en) 1998-12-09
PT882044E (pt) 2002-11-29
CZ258698A3 (cs) 1999-06-16
HN1997000013A (es) 1997-06-26
ZA971357B (en) 1998-08-18
AU1396497A (en) 1997-09-02
OA10712A (en) 2001-06-04
CA2245857C (en) 2002-10-01
DE69714019D1 (de) 2002-08-22
MA26419A1 (fr) 2004-12-20
BG102678A (en) 1999-04-30
CA2245857A1 (en) 1997-08-21
NO983776L (no) 1998-08-18
TR199801593T2 (xx) 1999-12-21
HUP9902810A3 (en) 2000-09-28
BR9707568A (pt) 1999-07-27
IS4783A (is) 1998-06-25
HRP970094A2 (en) 1998-06-30
PL328514A1 (en) 1999-02-01
CN1211251A (zh) 1999-03-17
AR005841A1 (es) 1999-07-14
WO1997030048A1 (en) 1997-08-21
ID16434A (id) 1997-09-25
DE69714019T2 (de) 2002-11-14
CO4650041A1 (es) 1998-09-03
ATE220676T1 (de) 2002-08-15
US6131226A (en) 2000-10-17

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