ES2176335T3 - Nuevo procedimiento de preparacion de diisopinocanfenilcloroborano. - Google Patents

Nuevo procedimiento de preparacion de diisopinocanfenilcloroborano.

Info

Publication number
ES2176335T3
ES2176335T3 ES95928320T ES95928320T ES2176335T3 ES 2176335 T3 ES2176335 T3 ES 2176335T3 ES 95928320 T ES95928320 T ES 95928320T ES 95928320 T ES95928320 T ES 95928320T ES 2176335 T3 ES2176335 T3 ES 2176335T3
Authority
ES
Spain
Prior art keywords
diisopinocanfenilcloroborano
preparation procedure
new preparation
diisopinocampheylchloroborane
pinene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95928320T
Other languages
English (en)
Inventor
Anthony On-Ping King
Robert D Larsen
Thomas R Verhoeven
Mangzhu Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2176335T3 publication Critical patent/ES2176335T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Detergent Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Lock And Its Accessories (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCEDIMIENTO MEJORADO PARA LA PREPARACION IN SITU DE DIISOCAMFEILCLOROBORANO, QUE CONSISTE EN HACER REACCIONAR BOROHIDRURO DE SODIO Y TRICLORURO DE SODIO, CON UN {AL}-PINENO. EL DIISOCAMFEILCLOROBORANO OBTENIDO DE ESA FORMA, SE PUEDE UTILIZAR, SIN NECESIDAD DE AISLAMIENTO, PARA REDUCIR CETONAS PROQUIRALES A SUS CORRESPONDIENTES ALCOHOLES DE ALTA PUREZA OPTICA.
ES95928320T 1994-08-11 1995-08-07 Nuevo procedimiento de preparacion de diisopinocanfenilcloroborano. Expired - Lifetime ES2176335T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/289,077 US5545758A (en) 1994-08-11 1994-08-11 Process for the preparation of diisopinocampheylchloroborane

Publications (1)

Publication Number Publication Date
ES2176335T3 true ES2176335T3 (es) 2002-12-01

Family

ID=23109960

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95928320T Expired - Lifetime ES2176335T3 (es) 1994-08-11 1995-08-07 Nuevo procedimiento de preparacion de diisopinocanfenilcloroborano.

Country Status (23)

Country Link
US (2) US5545758A (es)
EP (1) EP0775146B1 (es)
JP (1) JPH10504307A (es)
KR (1) KR100355916B1 (es)
CN (2) CN1051087C (es)
AT (1) ATE219087T1 (es)
AU (1) AU693588B2 (es)
BR (1) BR9508578A (es)
CA (1) CA2195776C (es)
CZ (2) CZ294311B6 (es)
DE (1) DE69527070T2 (es)
DK (1) DK0775146T3 (es)
ES (1) ES2176335T3 (es)
FI (1) FI120347B (es)
HU (1) HU215183B (es)
MX (1) MX9701087A (es)
NZ (1) NZ291101A (es)
PT (1) PT775146E (es)
RO (1) RO115882B1 (es)
RU (1) RU2150472C1 (es)
SI (1) SI0775146T1 (es)
UA (1) UA46741C2 (es)
WO (1) WO1996005206A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0211204A (pt) * 2001-07-17 2004-07-13 Upjohn Co Processo e intermediários para preparar latanoprost
WO2006021974A1 (en) * 2004-08-23 2006-03-02 Morepen Laboratories Limited A process for synthesizing diol (viii)-an intermediate of montelukast sodium
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
CN101225089B (zh) * 2007-01-17 2011-06-15 上海迪赛诺医药发展有限公司 制备二异松蒎基氯甲硼烷的方法
KR20100061571A (ko) 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
US20100055052A1 (en) * 2008-08-26 2010-03-04 James Albert Berta Processing System for Oral Care Compositions
CN101525344B (zh) * 2009-04-09 2011-10-05 霸州市路德精细化工有限公司 异松蒎基硼烷氯化物的制备方法
CN103030658B (zh) * 2012-06-29 2015-08-19 山东威智医药工业有限公司 二异松蒎基氯甲硼烷的工业化生产方法
CN103601708B (zh) * 2013-12-11 2015-06-17 武汉武药科技有限公司 一种前列素药物杂质的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043479A (en) * 1986-08-29 1991-08-27 Aldrich Chemical Company, Inc. Chemically and optically pure diisopinocampheylhaloboranes
CA2050820A1 (en) * 1990-09-24 1992-03-25 Pamela M. Simpson In-situ preparation of diisopinocamphenyl chloroborane
US5159116A (en) * 1991-07-15 1992-10-27 Aldrich Chemical Company, Inc. Chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes
US5220072A (en) * 1991-07-15 1993-06-15 Aldrich Chemical Co., Inc. Process of synthesizing chemically and optically pure B-halodiiso-2-ethylapopinocampheylboranes
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
US5220077A (en) * 1992-08-19 1993-06-15 Vista Chemical Company Alkoxylation process

Also Published As

Publication number Publication date
WO1996005206A1 (en) 1996-02-22
US5545758A (en) 1996-08-13
DK0775146T3 (da) 2002-07-15
US5693816A (en) 1997-12-02
MX9701087A (es) 1997-05-31
HUT77238A (hu) 1998-03-02
CZ286602B6 (cs) 2000-05-17
UA46741C2 (uk) 2002-06-17
FI970564A0 (fi) 1997-02-10
CN1051087C (zh) 2000-04-05
RU2150472C1 (ru) 2000-06-10
EP0775146B1 (en) 2002-06-12
RO115882B1 (ro) 2000-07-28
CZ38797A3 (en) 1997-10-15
FI120347B (fi) 2009-09-30
AU693588B2 (en) 1998-07-02
FI970564A (fi) 1997-02-10
JPH10504307A (ja) 1998-04-28
PT775146E (pt) 2002-09-30
KR100355916B1 (ko) 2003-01-06
DE69527070D1 (de) 2002-07-18
BR9508578A (pt) 1997-11-25
CN1240212A (zh) 2000-01-05
CN1122039C (zh) 2003-09-24
EP0775146A4 (en) 1998-01-07
CA2195776C (en) 2005-05-31
DE69527070T2 (de) 2003-03-20
HU215183B (hu) 1998-10-28
NZ291101A (en) 1998-11-25
CA2195776A1 (en) 1996-02-22
AU3213595A (en) 1996-03-07
CZ294311B6 (cs) 2004-11-10
EP0775146A1 (en) 1997-05-28
ATE219087T1 (de) 2002-06-15
SI0775146T1 (en) 2002-10-31
CN1159810A (zh) 1997-09-17

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