ES2176001T3 - Composicion con liberacion prolongada de principio activo apta para formar una microemulsion. - Google Patents

Composicion con liberacion prolongada de principio activo apta para formar una microemulsion.

Info

Publication number
ES2176001T3
ES2176001T3 ES99934821T ES99934821T ES2176001T3 ES 2176001 T3 ES2176001 T3 ES 2176001T3 ES 99934821 T ES99934821 T ES 99934821T ES 99934821 T ES99934821 T ES 99934821T ES 2176001 T3 ES2176001 T3 ES 2176001T3
Authority
ES
Spain
Prior art keywords
active principle
microemulsion
composition
polymeric matrix
ingestion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99934821T
Other languages
English (en)
Inventor
Philippe Barthelemy
Hassan Benameur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gattefosse Holding
Original Assignee
Gattefosse Holding
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gattefosse Holding filed Critical Gattefosse Holding
Application granted granted Critical
Publication of ES2176001T3 publication Critical patent/ES2176001T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Composición destinada a ser ingerida que comprende un sistema automicroemulsionable en contacto con una fase hidrófila aportada, después de ingestión, por el líquido fisiológico, comprendiendo dicho sistema automicroemulsionable: por lo menos un activo, una fase lipófila constituida por una mezcla de mono-, di- y triglicéridos con unos ácidos grasos con C8-C18 y de mono- y diésteres de polietilenglicol que presentan un balance hidrófilo/lipófilo (HLB) inferior a 16; un agente tensioactivo (TA) a base de glicéridos que presentan un HLB inferior a 16 elegido en el grupo que comprende los glicéridos poliglicosilados saturados con C8-C10 y los ésteres oleicos del poliglicerol; un agente cotensioactivo (CoTA) elegido en el grupo que comprende los ésteres de ácidos grasos del propilenglicol, los ésteres oleicos del poliglicerol, el etildiglicol; estando la relación TA-CoTA comprendida entre 0,5 y 6; caracterizada porque dicha composición comprende además una matriz polimérica inerte, que representa de 0,5 a 40 % en peso de la composición total, no ionizable a pH fisiológico, dispersada en el sistema automicroemulsionable antes de ingestión, siendo dicha matriz polimérica apta, después de ingestión, para formar, en contacto con el líquido fisiológico, una matriz polimérica gelificada que permite liberar por difusión, de forma continua y prolongada, el activo entonces microemulsionado.
ES99934821T 1998-08-07 1999-07-30 Composicion con liberacion prolongada de principio activo apta para formar una microemulsion. Expired - Lifetime ES2176001T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9810313A FR2782006B1 (fr) 1998-08-07 1998-08-07 Composition a liberation prolongee apte a former une micro-emulsion

Publications (1)

Publication Number Publication Date
ES2176001T3 true ES2176001T3 (es) 2002-11-16

Family

ID=9529608

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99934821T Expired - Lifetime ES2176001T3 (es) 1998-08-07 1999-07-30 Composicion con liberacion prolongada de principio activo apta para formar una microemulsion.

Country Status (10)

Country Link
US (1) US6309665B2 (es)
EP (1) EP1102581B1 (es)
JP (1) JP2002522379A (es)
KR (1) KR20010072292A (es)
AT (1) ATE217791T1 (es)
AU (1) AU5047099A (es)
DE (1) DE69901567T2 (es)
ES (1) ES2176001T3 (es)
FR (1) FR2782006B1 (es)
WO (1) WO2000007573A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838349B1 (fr) * 2002-04-15 2004-06-25 Laurence Paris Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication
DE10226990A1 (de) * 2002-06-18 2004-03-18 Sanguibiotech Ag Topisch applizierbare Mikro-Emulsionen mit binärer Phasen- und Wirkstoffdifferenzierbarkeit, deren Herstellung und deren Verwendung, insbesondere zur Versorgung der Haut mit bioverfügbarem Sauerstoff
GB0222612D0 (en) * 2002-09-30 2002-11-06 Univ Gent Controlled delivery system for bioactive substances
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
CA2512454C (en) 2003-02-04 2012-10-30 Bracco Research Sa Ultrasound contrast agents and process for the preparation thereof
CA2547024C (en) 2003-12-22 2013-12-17 Bracco Research Sa Gas-filled microvesicle assembly for contrast imaging
ES2425937T3 (es) * 2004-03-24 2013-10-18 Takeda Pharmaceutical Company Limited Estabilizante de emulsión
US20050220866A1 (en) * 2004-04-02 2005-10-06 Dr. Reddy's Laboratories Limited Novel capsule formulations of etoposide for oral use
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
EP1784228B1 (en) 2004-08-18 2016-10-05 Bracco Suisse SA Gas-filled microvesicles composition for contrast imaging
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
EP2985026B1 (en) 2005-04-15 2022-08-03 Clarus Therapeutics, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
CN101360485B (zh) * 2005-10-26 2013-04-17 班纳制药公司 作为胶囊填充物的基于亲水性载体的双重控释基质系统
US8293270B2 (en) * 2005-10-26 2012-10-23 Banner Pharmacaps, Inc. Lipophilic vehicle-based dual controlled release matrix system
DE102008015299A1 (de) 2008-03-18 2009-09-24 Pkh Gmbh Halle Kolloidales Trägersystem
SI2600850T1 (sl) 2010-08-04 2018-12-31 Gruenenthal Gmbh Farmacevtska oblika odmerka, ki zajema 6'-fluoro-(N-metil- ali N,N- dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,B)indol)-4-amin, za zdravljenje nociceptivne bolečine
CN102846544B (zh) * 2011-08-29 2014-01-15 华北制药集团新药研究开发有限责任公司 一种难溶药物的自微乳组合物
DE102012019029A1 (de) 2012-09-27 2014-03-27 Alf Lamprecht Arzneiformulierungen zur oralen Gabe von therapeutischen Substanzen und Verfahren zur Herstellung
WO2015100406A1 (en) 2013-12-26 2015-07-02 Clarus Therapeutics, Inc. Use of oral pharmaceutical products combining testosterone esters with hypolipidemic agents
US10245034B2 (en) * 2015-08-31 2019-04-02 Ethicon Llc Inducing tissue adhesions using surgical adjuncts and medicants
US10569071B2 (en) 2015-08-31 2020-02-25 Ethicon Llc Medicant eluting adjuncts and methods of using medicant eluting adjuncts
KR101679380B1 (ko) * 2015-09-10 2016-11-25 주식회사 유유제약 두타스테리드를 포함하는 약학적 조성물 및 이를 포함하는 캡슐 제형

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797286A (en) * 1985-11-12 1989-01-10 Eli Lilly And Company Orally administerable sustained release pharmaceutical formulations
FR2629363B1 (fr) * 1988-03-29 1991-10-11 Rubinstein Inc H Particules d'emulsion gelifiees et leur utilisation, notamment en cosmetologie
GB9022788D0 (en) * 1990-10-19 1990-12-05 Cortecs Ltd Pharmaceutical formulations
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
FR2710535B1 (fr) * 1993-09-30 1995-11-24 Gattefosse Ets Sa Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.
US6054136A (en) * 1993-09-30 2000-04-25 Gattefosse S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US5545628A (en) * 1995-01-10 1996-08-13 Galephar P.R. Inc. Pharmaceutical composition containing fenofibrate
FR2748209B1 (fr) * 1996-05-06 1998-06-05 Adir Composition pharmaceutique a base de matrices lipophiles stabilisees pour la liberation controlee de principes actifs
US5993858A (en) * 1996-06-14 1999-11-30 Port Systems L.L.C. Method and formulation for increasing the bioavailability of poorly water-soluble drugs
BE1011363A3 (fr) * 1997-09-11 1999-08-03 Smb Technology Capsules semi-solides autoemulsionnables matricielles a action prolongee.

Also Published As

Publication number Publication date
FR2782006B1 (fr) 2002-04-19
US20010004459A1 (en) 2001-06-21
AU5047099A (en) 2000-02-28
US6309665B2 (en) 2001-10-30
EP1102581A1 (fr) 2001-05-30
EP1102581B1 (fr) 2002-05-22
FR2782006A1 (fr) 2000-02-11
DE69901567D1 (de) 2002-06-27
WO2000007573A1 (fr) 2000-02-17
ATE217791T1 (de) 2002-06-15
KR20010072292A (ko) 2001-07-31
DE69901567T2 (de) 2002-10-31
JP2002522379A (ja) 2002-07-23

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