ES2172195T3 - Inhibicion de la cristalizacion en dispositivos transdermales. - Google Patents
Inhibicion de la cristalizacion en dispositivos transdermales.Info
- Publication number
- ES2172195T3 ES2172195T3 ES98944097T ES98944097T ES2172195T3 ES 2172195 T3 ES2172195 T3 ES 2172195T3 ES 98944097 T ES98944097 T ES 98944097T ES 98944097 T ES98944097 T ES 98944097T ES 2172195 T3 ES2172195 T3 ES 2172195T3
- Authority
- ES
- Spain
- Prior art keywords
- drug component
- active drug
- active
- matrix
- effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
Procedimiento de preparación de un dispositivo de administración transdermal que incluye las etapas de preparación de la mezcla de un componente de fármaco activo en cantidad suficiente para tener un efecto farmacéutico o fisiológico en la utilización del dispositivo y un material que forma la matriz, y disponiendo dicha mezcla en o sobre un soporte para formar una matriz que contenga dicho componente de fármaco activo, siendo dicho componente de fármaco activo una fármaco de hormona activo o un conjunto de fármacos de hormonas activas, estando el procedimiento caracterizado por el paso de mezclar de al menos uno de los mencionados materiales que constituyen la matriz y dicho componente de fármaco activo con una cantidad medida de un esteroide, teniendo dicha cantidad medida un efecto de inhibición de la cristalización de dicho componente de fármaco activo al almacenar el dispositivo terminado y estando en una cantidad insuficiente para provocar un efecto farmacéutico o siológico significativo cuando se utiliza el dispositivo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9720470.5A GB9720470D0 (en) | 1997-09-25 | 1997-09-25 | Inhibition of crystallization in transdermal devices |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2172195T3 true ES2172195T3 (es) | 2002-09-16 |
Family
ID=10819670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98944097T Expired - Lifetime ES2172195T3 (es) | 1997-09-25 | 1998-09-24 | Inhibicion de la cristalizacion en dispositivos transdermales. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6465005B1 (es) |
EP (1) | EP1023055B1 (es) |
AR (1) | AR013520A1 (es) |
BR (1) | BR9812523A (es) |
DE (1) | DE69803592T2 (es) |
ES (1) | ES2172195T3 (es) |
GB (1) | GB9720470D0 (es) |
WO (1) | WO1999015156A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6465004B1 (en) | 1999-06-05 | 2002-10-15 | Noven Pharmaceuticals, Inc. | Solubility enhancement of drugs in transdermal drug delivery systems and methods of use |
EP1323431B1 (en) * | 2000-08-03 | 2010-10-27 | Antares Pharma IPL AG | Composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US20020106402A1 (en) * | 2000-12-05 | 2002-08-08 | Hartwig Rod Lawson | Crystallization inhibition of drugs in transdermal drug delivery systems and methods of use |
AU2002320038B2 (en) | 2001-06-18 | 2007-07-05 | Noven Pharmaceuticals, Inc. | Enhanced drug delivery in transdermal systems |
US20050058695A1 (en) * | 2002-05-30 | 2005-03-17 | Watson Pharmaccuticals, Inc. | Norethindrone sustained release formulations and methods associated therewith |
WO2003101461A1 (en) * | 2002-05-30 | 2003-12-11 | Watson Pharmaceuticals, Inc. | Norethindrone sustained release formulations and methods associated therewith |
US7387788B1 (en) | 2003-10-10 | 2008-06-17 | Antares Pharma Ipl Ag | Pharmaceutical compositions of nicotine and methods of use thereof |
JP5619337B2 (ja) | 2003-10-10 | 2014-11-05 | フェリング ビー.ブイ. | 皮膚残渣を最小限に抑えるための経皮的医薬製剤 |
TW200514582A (en) * | 2003-10-31 | 2005-05-01 | Hisamitsu Pharmaceutical Co | Transdermal preparation and method for reducing side effect in pergolide therapy |
US7425340B2 (en) * | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
WO2007124250A2 (en) | 2006-04-21 | 2007-11-01 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
KR100699582B1 (ko) | 2005-07-11 | 2007-03-23 | 삼성전기주식회사 | 출력 버퍼회로 |
US10137135B2 (en) | 2005-08-15 | 2018-11-27 | Allergan Sales, Llc | Formulations and methods for providing progestin-only contraception while minimizing adverse side effects associated therewith |
FR2895679B1 (fr) * | 2005-12-29 | 2012-06-08 | Pf Medicament | Stabilisation de testosterone au sein de dispositifs transdermiques |
US20080226698A1 (en) | 2007-03-16 | 2008-09-18 | Mylan Technologies, Inc. | Amorphous drug transdermal systems, manufacturing methods, and stabilization |
WO2010042152A2 (en) * | 2008-10-06 | 2010-04-15 | Mylan Technologies, Inc. | Amorphous rotigotine transdermal system |
IN2014DN03247A (es) * | 2011-11-04 | 2015-05-22 | Agile Therapeutics Inc | |
PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5023084A (en) | 1986-12-29 | 1991-06-11 | Rutgers, The State University Of New Jersey | Transdermal estrogen/progestin dosage unit, system and process |
US4832953A (en) | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
US4906475A (en) | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
WO1989007951A1 (en) | 1988-02-26 | 1989-09-08 | Riker Laboratories, Incorporated | Transdermal estradiol delivery system |
US5223261A (en) | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
US4814168A (en) | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US4994267A (en) | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
IL92496A0 (en) | 1988-12-01 | 1990-08-31 | Schering Corp | Compositions for transdermal delivery of estradiol |
AR246186A1 (es) | 1989-11-17 | 1994-07-29 | Beta Pharm Co | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
GB9021674D0 (en) | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
US5518734A (en) * | 1991-09-25 | 1996-05-21 | Beta Pharmaceuticals Co. | Transdermal delivery system for estradiol and process for manufacturing said device |
US5676968A (en) * | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
DE4210711A1 (de) | 1991-10-31 | 1993-05-06 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | Transdermale therapeutische systeme mit kristallisationsinhibitoren |
US5460820B1 (en) * | 1993-08-03 | 1999-08-03 | Theratech Inc | Method for providing testosterone and optionally estrogen replacement therapy to women |
DE4405898A1 (de) | 1994-02-18 | 1995-08-24 | Schering Ag | Transdermale therapeutische Systeme enthaltend Sexualsteroide |
DE4429664C2 (de) | 1994-08-20 | 1997-09-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
US5906830A (en) * | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
-
1997
- 1997-09-25 GB GBGB9720470.5A patent/GB9720470D0/en not_active Ceased
-
1998
- 1998-09-24 US US09/509,122 patent/US6465005B1/en not_active Expired - Fee Related
- 1998-09-24 WO PCT/GB1998/002880 patent/WO1999015156A1/en active IP Right Grant
- 1998-09-24 EP EP98944097A patent/EP1023055B1/en not_active Expired - Lifetime
- 1998-09-24 DE DE69803592T patent/DE69803592T2/de not_active Expired - Fee Related
- 1998-09-24 ES ES98944097T patent/ES2172195T3/es not_active Expired - Lifetime
- 1998-09-24 BR BR9812523-0A patent/BR9812523A/pt not_active Application Discontinuation
- 1998-09-25 AR ARP980104789A patent/AR013520A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1023055A1 (en) | 2000-08-02 |
GB9720470D0 (en) | 1997-11-26 |
DE69803592D1 (de) | 2002-03-14 |
BR9812523A (pt) | 2000-07-25 |
AR013520A1 (es) | 2000-12-27 |
WO1999015156B1 (en) | 1999-06-10 |
WO1999015156A1 (en) | 1999-04-01 |
DE69803592T2 (de) | 2002-09-19 |
US6465005B1 (en) | 2002-10-15 |
EP1023055B1 (en) | 2002-01-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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