ES2171398T3 - Acidos nucleicos viricos vegetales recombinantes. - Google Patents
Acidos nucleicos viricos vegetales recombinantes.Info
- Publication number
- ES2171398T3 ES2171398T3 ES92916441T ES92916441T ES2171398T3 ES 2171398 T3 ES2171398 T3 ES 2171398T3 ES 92916441 T ES92916441 T ES 92916441T ES 92916441 T ES92916441 T ES 92916441T ES 2171398 T3 ES2171398 T3 ES 2171398T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleic acids
- plant viral
- native
- recombinant
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1074—Cyclomaltodextrin glucanotransferase (2.4.1.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/18—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with another compound as one donor, and incorporation of one atom of oxygen (1.14.18)
- C12Y114/18001—Tyrosinase (1.14.18.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/12011—Geminiviridae
- C12N2750/12022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
LA INVENCION SE DIRIGE A ACIDOS NUCLEICOS VIRALES DE PLANTAS RECOMBINANTES Y A LOS ANFITRIONES INFECTADOS POR LAS MISMAS. LOS ACIDOS NUCLEICOS VIRALES DE PLANTAS RECOMBINANTES COMPRENDEN UN PROMOTOR SUBGENOMICO VIRAL DE LA PLANTA NATIVA, AL MENOS UN PROMOTOR SUBGENOMICO VIRAL DE LA PLANTA NO NATIVA, UNA SECUENCIA QUE CODIFICA UNA PROTEINA DE RECUBRIMIENTO VIRAL DE LA PLANTA, Y OPCIONALMENTE, AL MENOS UNA SECUENCIA DE ACIDO NUCLEICO NO NATIVA QUE SE TRANSCRIBE O EXPRESA EN LA PLANTA ANFITRIONA INFECTADA. LOS ACIDOS NUCLEICOS VIRALES DE PLANTAS RECOMBINANTES SON ESTABLES, CAPACES DE INFECCIONES SISTEMICAS Y CAPACES DE UNA TRANSCRIPCION O EXPRESION ESTABLE EN LA PLANTA ANFITRIONA DE LAS SECUENCIAS DE ACIDO NUCLEICO NO NATIVAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73914391A | 1991-08-01 | 1991-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171398T3 true ES2171398T3 (es) | 2002-09-16 |
Family
ID=24971018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92916441T Expired - Lifetime ES2171398T3 (es) | 1991-08-01 | 1992-07-31 | Acidos nucleicos viricos vegetales recombinantes. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0596979B1 (es) |
JP (3) | JPH07503361A (es) |
KR (1) | KR100238904B1 (es) |
AT (1) | ATE212671T1 (es) |
AU (1) | AU683412B2 (es) |
CA (1) | CA2114636C (es) |
DE (1) | DE69232393T2 (es) |
DK (1) | DK0596979T3 (es) |
ES (1) | ES2171398T3 (es) |
WO (1) | WO1993003161A1 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284492B1 (en) * | 1988-02-26 | 2001-09-04 | Large Scale Biology Corporation | Recombinant animal viral nucleic acids |
US6660500B2 (en) | 1988-02-26 | 2003-12-09 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
US5977438A (en) | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
US7033835B1 (en) | 1988-02-26 | 2006-04-25 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
US5922602A (en) * | 1988-02-26 | 1999-07-13 | Biosource Technologies, Inc. | Cytoplasmic inhibition of gene expression |
US6054566A (en) | 1988-02-26 | 2000-04-25 | Biosource Technologies, Inc. | Recombinant animal viral nucleic acids |
GB9108386D0 (en) | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
US5491076A (en) * | 1993-11-01 | 1996-02-13 | The Texas A&M University System | Expression of foreign genes using a replicating polyprotein producing virus vector |
GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
FR2722798B1 (fr) * | 1994-07-25 | 1996-09-13 | Toulouse Inst Nat Polytech | 1procede de production d'acides gras2plantes oleagineuses |
NZ294014A (en) | 1994-10-18 | 1999-02-25 | Scottish Crop Research Inst | A method of producing a rod-shaped or pseudovirus capable of replicating and assembling in plants |
FR2733249B1 (fr) * | 1995-04-20 | 1997-06-06 | Biocem | Lipase gastrique de chien recombinante et polypeptides derives produits par les plantes, leurs procedes d'obtention et leurs utilisations |
US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
FR2736930B1 (fr) * | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
US5939262A (en) | 1996-07-03 | 1999-08-17 | Ambion, Inc. | Ribonuclease resistant RNA preparation and utilization |
FR2754827B1 (fr) * | 1996-10-17 | 1998-12-24 | Biocem | Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations |
US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
GB9703146D0 (en) | 1997-02-14 | 1997-04-02 | Innes John Centre Innov Ltd | Methods and means for gene silencing in transgenic plants |
FI110323B (fi) | 1997-06-02 | 2002-12-31 | Timo Korpela | Rekombinanttikonstrukti geenin ilmentämisen lisäämiseksi kasveissa |
EP3214177A3 (en) | 1998-04-08 | 2017-11-22 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
DE69941261D1 (de) * | 1998-06-22 | 2009-09-24 | Ca Minister Agriculture & Food | Herstellung von il-10 in einen pflanzenbioreaktor aus pflanzen, die nicht zur ernährung verwendet werden |
US7148400B1 (en) | 1999-04-20 | 2006-12-12 | Bayer Bioscience N.V. | Methods and means for delivering inhibitory RNA to plants and applications thereof |
WO2001007613A2 (en) * | 1999-07-21 | 2001-02-01 | Large Scale Biology Corporation | Method for enhancing rna or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids |
WO2003052108A2 (en) | 2001-12-18 | 2003-06-26 | Bayer Bioscience N.V. | Improved methods and means for delivering inhibitory rna to plants and applications thereof |
DE10212892A1 (de) | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
ATE405658T1 (de) | 2002-07-26 | 2008-09-15 | Basf Plant Science Gmbh | Neue selektionsverfahren |
CN1926238A (zh) * | 2004-02-27 | 2007-03-07 | 陶氏化学公司 | 植物细胞中的高效肽生产 |
CN101203611B (zh) | 2005-04-19 | 2013-08-14 | 巴斯福植物科学有限公司 | 控制基因表达的改良方法 |
EP1931789B1 (en) | 2005-09-20 | 2016-05-04 | BASF Plant Science GmbH | Methods for controlling gene expression using ta-siran |
JP2007151435A (ja) * | 2005-12-02 | 2007-06-21 | Niigata Univ | デンプン集積能力の高い形質転換植物およびその製造方法 |
CA2674499A1 (en) | 2007-02-06 | 2008-08-14 | Basf Plant Science Gmbh | Use of alanine racemase genes to confer nematode resistance to plants |
CN101605896A (zh) | 2007-02-06 | 2009-12-16 | 巴斯福植物科学有限公司 | 使用rna干扰控制线虫的组合物和方法 |
US20100115660A1 (en) | 2007-02-08 | 2010-05-06 | Basf Plant Science Gmbh | Compositions and Methods Using RNA Interference of OPR3-Like Gene For Control of Nematodes |
EP2115148B1 (en) | 2007-02-09 | 2011-09-14 | BASF Plant Science GmbH | Compositions and methods using rna interference of cdpk-like for control of nematodes |
CN101679995A (zh) | 2007-03-15 | 2010-03-24 | 巴斯福植物科学有限公司 | 线虫几丁质酶基因用于控制植物寄生性线虫的用途 |
WO2010023186A1 (en) | 2008-08-27 | 2010-03-04 | Basf Plant Science Gmbh | Nematode-resistant transgenic plants |
EP2376635B1 (en) | 2008-12-11 | 2012-09-26 | BASF Plant Science GmbH | Plant root-specific nematode resistance |
CN102361987A (zh) | 2009-03-20 | 2012-02-22 | 巴斯夫植物科学有限公司 | 抗线虫的转基因植物 |
WO2010145846A1 (en) | 2009-06-15 | 2010-12-23 | Bayer Bioscience N.V. | Nicotiana benthamiana plants deficient in xylosyltransferase activity |
BR112012003928A2 (pt) | 2009-08-25 | 2019-09-24 | Basf Plant Science Co Gmbh | planta transgênica transformada com um vetor de expressão, semente, vetor de expressão, método de produzir uma planta transgênica resistente a nematóide e método de aumentar o rendimento de uma planta de safra |
WO2011069953A1 (en) | 2009-12-09 | 2011-06-16 | Basf Plant Science Company Gmbh | Methods for increasing the resistance of plants to fungi by silencing the fungal smt1-gene |
EP2539362A1 (en) | 2010-02-23 | 2013-01-02 | BASF Plant Science Company GmbH | Nematode-resistant transgenic plants |
CA2822004A1 (en) | 2010-12-20 | 2012-06-28 | Basf Plant Science Company Gmbh | Nematode-resistant transgenic plants |
EP2535416A1 (en) | 2011-05-24 | 2012-12-19 | BASF Plant Science Company GmbH | Development of phytophthora resistant potato with increased yield |
US9181532B2 (en) | 2011-07-29 | 2015-11-10 | Icon Genetics Gmbh | Production of galactosylated N-glycans in plants |
CA2850571C (en) | 2011-10-04 | 2021-01-05 | Icon Genetics Gmbh | Nicotiana benthamiana plants deficient in fucosyltransferase activity |
WO2013050318A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013050611A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013050593A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013053686A1 (en) | 2011-10-10 | 2013-04-18 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013053711A1 (en) | 2011-10-10 | 2013-04-18 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
CA2897485A1 (en) | 2013-01-29 | 2014-08-07 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing hcp6 |
WO2014117988A1 (en) | 2013-01-29 | 2014-08-07 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing hcp7 |
CA2891424A1 (en) | 2013-01-29 | 2014-08-07 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing ein2 |
BR112015021857B1 (pt) | 2013-03-08 | 2022-05-10 | Basf Plant Science Company Gmbh | Método para aumentar a resistência à ferrugem da soja em uma planta de soja que expressa proteína mybtf e método para a produção de uma planta de soja transgênica que expressa proteína mybtf |
EP3010329B1 (en) | 2013-06-17 | 2019-11-20 | Bayer CropScience Aktiengesellschaft | Method for identifying substances which prime cells for a stress response and cells for use in this method |
ES2675362T3 (es) | 2013-07-10 | 2018-07-10 | Basf Se | ARNi para el control de hongos y oomicetos fitopatógenos mediante la inhibición de la expresión de genes CYP51 |
BR112017016688B1 (pt) | 2015-02-04 | 2024-01-23 | Basf Plant Science Company Gmbh | Método para aumentar a resistência fúngica, método para a produção de um produto e método para criar uma planta resistente a fungos |
US10934554B2 (en) | 2015-05-28 | 2021-03-02 | Tweed, Inc. | Cannabis plants having modified expression of THCA synthase |
EP3054014A3 (en) | 2016-05-10 | 2016-11-23 | BASF Plant Science Company GmbH | Use of a fungicide on transgenic plants |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4407956A (en) * | 1981-03-13 | 1983-10-04 | The Regents Of The University Of California | Cloned cauliflower mosaic virus DNA as a plant vehicle |
US5034322A (en) * | 1983-01-17 | 1991-07-23 | Monsanto Company | Chimeric genes suitable for expression in plant cells |
EP0221044B1 (en) * | 1985-10-25 | 1992-09-02 | Monsanto Company | Novel plant vectors |
EP0278667B1 (en) * | 1987-02-09 | 1994-07-20 | Mycogen Plant Science, Inc. | Hybrid RNA virus |
NL9001711A (nl) * | 1989-10-03 | 1991-05-01 | Clovis Matton N V | Genetische manipulaties met recombinant dna, dat van rna virus afgeleide sequenties omvat. |
-
1992
- 1992-07-31 ES ES92916441T patent/ES2171398T3/es not_active Expired - Lifetime
- 1992-07-31 AU AU33511/93A patent/AU683412B2/en not_active Ceased
- 1992-07-31 EP EP92916441A patent/EP0596979B1/en not_active Expired - Lifetime
- 1992-07-31 DK DK92916441T patent/DK0596979T3/da active
- 1992-07-31 JP JP4511611A patent/JPH07503361A/ja not_active Withdrawn
- 1992-07-31 CA CA002114636A patent/CA2114636C/en not_active Expired - Fee Related
- 1992-07-31 DE DE69232393T patent/DE69232393T2/de not_active Expired - Fee Related
- 1992-07-31 AT AT92916441T patent/ATE212671T1/de not_active IP Right Cessation
- 1992-07-31 KR KR1019940700361A patent/KR100238904B1/ko not_active IP Right Cessation
- 1992-07-31 WO PCT/US1992/006359 patent/WO1993003161A1/en active IP Right Grant
-
2000
- 2000-07-12 JP JP2000212070A patent/JP3545683B2/ja not_active Expired - Fee Related
-
2001
- 2001-10-10 JP JP2001313207A patent/JP3316209B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0596979B1 (en) | 2002-01-30 |
WO1993003161A1 (en) | 1993-02-18 |
CA2114636A1 (en) | 1993-02-18 |
AU683412B2 (en) | 1997-11-13 |
JP2002171976A (ja) | 2002-06-18 |
DK0596979T3 (da) | 2002-05-13 |
EP0596979A1 (en) | 1994-05-18 |
KR100238904B1 (ko) | 2000-01-15 |
CA2114636C (en) | 2006-11-28 |
JP2001054394A (ja) | 2001-02-27 |
DE69232393D1 (de) | 2002-03-14 |
DE69232393T2 (de) | 2002-08-29 |
JP3316209B2 (ja) | 2002-08-19 |
ATE212671T1 (de) | 2002-02-15 |
EP0596979A4 (en) | 1994-07-13 |
JP3545683B2 (ja) | 2004-07-21 |
JPH07503361A (ja) | 1995-04-13 |
AU3351193A (en) | 1993-03-02 |
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