ATE212671T1 - Rekombinierte virale nukleinsäure aus pflanzen - Google Patents
Rekombinierte virale nukleinsäure aus pflanzenInfo
- Publication number
- ATE212671T1 ATE212671T1 AT92916441T AT92916441T ATE212671T1 AT E212671 T1 ATE212671 T1 AT E212671T1 AT 92916441 T AT92916441 T AT 92916441T AT 92916441 T AT92916441 T AT 92916441T AT E212671 T1 ATE212671 T1 AT E212671T1
- Authority
- AT
- Austria
- Prior art keywords
- plant viral
- nucleic acid
- native
- viral nucleic
- plant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8202—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation by biological means, e.g. cell mediated or natural vector
- C12N15/8203—Virus mediated transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C12N9/1074—Cyclomaltodextrin glucanotransferase (2.4.1.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/18—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with another compound as one donor, and incorporation of one atom of oxygen (1.14.18)
- C12Y114/18001—Tyrosinase (1.14.18.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/12011—Geminiviridae
- C12N2750/12022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73914391A | 1991-08-01 | 1991-08-01 | |
PCT/US1992/006359 WO1993003161A1 (en) | 1990-10-22 | 1992-07-31 | Recombinant plant viral nucleic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE212671T1 true ATE212671T1 (de) | 2002-02-15 |
Family
ID=24971018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT92916441T ATE212671T1 (de) | 1991-08-01 | 1992-07-31 | Rekombinierte virale nukleinsäure aus pflanzen |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0596979B1 (de) |
JP (3) | JPH07503361A (de) |
KR (1) | KR100238904B1 (de) |
AT (1) | ATE212671T1 (de) |
AU (1) | AU683412B2 (de) |
CA (1) | CA2114636C (de) |
DE (1) | DE69232393T2 (de) |
DK (1) | DK0596979T3 (de) |
ES (1) | ES2171398T3 (de) |
WO (1) | WO1993003161A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6660500B2 (en) | 1988-02-26 | 2003-12-09 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
US7033835B1 (en) | 1988-02-26 | 2006-04-25 | Large Scale Biology Corporation | Production of peptides in plants as viral coat protein fusions |
US6284492B1 (en) * | 1988-02-26 | 2001-09-04 | Large Scale Biology Corporation | Recombinant animal viral nucleic acids |
US5977438A (en) | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
US5922602A (en) * | 1988-02-26 | 1999-07-13 | Biosource Technologies, Inc. | Cytoplasmic inhibition of gene expression |
US6054566A (en) | 1988-02-26 | 2000-04-25 | Biosource Technologies, Inc. | Recombinant animal viral nucleic acids |
GB9108386D0 (en) | 1991-04-19 | 1991-06-05 | Agricultural Genetics Co | Modified plant viruses as vectors |
US5491076A (en) * | 1993-11-01 | 1996-02-13 | The Texas A&M University System | Expression of foreign genes using a replicating polyprotein producing virus vector |
GB9414118D0 (en) * | 1994-07-13 | 1994-08-31 | Axis Genetics Ltd | Modified plant viruses as vectors of heterologous peptides |
FR2722798B1 (fr) * | 1994-07-25 | 1996-09-13 | Toulouse Inst Nat Polytech | 1procede de production d'acides gras2plantes oleagineuses |
WO1996012027A1 (en) * | 1994-10-18 | 1996-04-25 | Scottish Crop Research Institute | Method of producing a chimeric protein |
FR2733249B1 (fr) | 1995-04-20 | 1997-06-06 | Biocem | Lipase gastrique de chien recombinante et polypeptides derives produits par les plantes, leurs procedes d'obtention et leurs utilisations |
US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
FR2736930B1 (fr) * | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
US5939262A (en) | 1996-07-03 | 1999-08-17 | Ambion, Inc. | Ribonuclease resistant RNA preparation and utilization |
FR2754827B1 (fr) * | 1996-10-17 | 1998-12-24 | Biocem | Lipases pancreatiques et/ou colipases recombinantes et polypeptides dervies produits par les plantes, leurs procedes d'obtention et leurs utilisations |
US7361331B2 (en) | 1996-10-18 | 2008-04-22 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food | Plant bioreactors |
GB9703146D0 (en) | 1997-02-14 | 1997-04-02 | Innes John Centre Innov Ltd | Methods and means for gene silencing in transgenic plants |
FI110323B (fi) | 1997-06-02 | 2002-12-31 | Timo Korpela | Rekombinanttikonstrukti geenin ilmentämisen lisäämiseksi kasveissa |
WO1999053050A1 (en) | 1998-04-08 | 1999-10-21 | Commonwealth Scientific And Industrial Research Organisation | Methods and means for obtaining modified phenotypes |
ES2336861T3 (es) * | 1998-06-22 | 2010-04-16 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food | Produccion de il-10 en biorreactor de planta de cultivo no alimenticia. |
US7148400B1 (en) | 1999-04-20 | 2006-12-12 | Bayer Bioscience N.V. | Methods and means for delivering inhibitory RNA to plants and applications thereof |
AU6235000A (en) * | 1999-07-21 | 2001-02-13 | Large Scale Biology Corporation | Method for enhancing rna or protein production using non-native 5' untranslated sequences in recombinant viral nucleic acids |
AU2002361997B2 (en) | 2001-12-18 | 2007-10-04 | Bayer Bioscience N.V. | Improved methods and means for delivering inhibitory RNA to plants and applications thereof |
DE10212892A1 (de) | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
EP1527183B1 (de) | 2002-07-26 | 2008-08-20 | BASF Plant Science GmbH | Neue selektionsverfahren |
EP1720990A4 (de) * | 2004-02-27 | 2008-04-30 | Dow Global Technologies Inc | Hocheffiziente peptidproduktion in pflanzenzellen |
AU2006237317B8 (en) | 2005-04-19 | 2011-05-12 | Basf Plant Science Gmbh | Improved methods controlling gene expression |
CN101268194A (zh) | 2005-09-20 | 2008-09-17 | 巴斯福植物科学有限公司 | 使用ta-siRNA调控基因表达的方法 |
JP2007151435A (ja) * | 2005-12-02 | 2007-06-21 | Niigata Univ | デンプン集積能力の高い形質転換植物およびその製造方法 |
CN101605903B (zh) | 2007-02-06 | 2012-09-05 | 巴斯福植物科学有限公司 | 丙氨酸消旋酶基因对植物赋予线虫抗性的用途 |
US20100011463A1 (en) | 2007-02-06 | 2010-01-14 | Basf Plant Science Gmbh | Compositions and Methods Using RNA Interference for Control of Nematodes |
CN101605894A (zh) | 2007-02-08 | 2009-12-16 | 巴斯福植物科学有限公司 | 用opr3-样基因的rna干扰控制线虫的组合物和方法 |
MX2009007766A (es) | 2007-02-09 | 2009-07-30 | Basf Plant Science Gmbh | Composiciones y metodos que utilizan arn de interferencia de tipo cdpk para el control de nematodos. |
MX2009008601A (es) | 2007-03-15 | 2009-08-21 | Basf Plant Science Gmbh | Uso de genes de quitinasa de nematodos con el fin de controlar nematodos que son parasitos de plantas. |
MX2011001356A (es) | 2008-08-27 | 2011-03-29 | Basf Plant Science Gmbh | Plantas transgenicas resistentes a nematodos. |
MX2011005773A (es) | 2008-12-11 | 2011-06-30 | Basf Plant Science Gmbh | Planta con resistencia a nematodos especificos de raiz. |
CN102361987A (zh) | 2009-03-20 | 2012-02-22 | 巴斯夫植物科学有限公司 | 抗线虫的转基因植物 |
CA2765287C (en) | 2009-06-15 | 2018-12-11 | Bayer Bioscience N.V. | Nicotiana benthamiana plants deficient in xylosyltransferase activity |
CA2770572A1 (en) | 2009-08-25 | 2011-03-03 | Basf Plant Science Company Gmbh | Nematode-resistant transgenic plants |
EP2510090A1 (de) | 2009-12-09 | 2012-10-17 | BASF Plant Science Company GmbH | Verfahren zur steigerung der resistenz von pflanzen gegenüber pilzen durch ausschaltung des smt1-pilzgens |
EP2539362A1 (de) | 2010-02-23 | 2013-01-02 | BASF Plant Science Company GmbH | Nematodenresistente transgene pflanzen |
AR087935A1 (es) | 2010-12-20 | 2014-04-30 | Basf Plant Science Co Gmbh | Plantas transgenicas resistentes a los nematodos |
EP2535416A1 (de) | 2011-05-24 | 2012-12-19 | BASF Plant Science Company GmbH | Entwicklung einer Phytophthora-resistenten Kartoffel mit verbessertem Ertrag |
US9181532B2 (en) | 2011-07-29 | 2015-11-10 | Icon Genetics Gmbh | Production of galactosylated N-glycans in plants |
JP6104252B2 (ja) | 2011-10-04 | 2017-03-29 | アイコン・ジェネティクス・ゲーエムベーハー | フコシルトランスフェラーゼ活性が欠損したニコチアナ・ベンサミアナ植物 |
WO2013050593A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013050611A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013050318A1 (en) | 2011-10-07 | 2013-04-11 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013053686A1 (en) | 2011-10-10 | 2013-04-18 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
WO2013053711A1 (en) | 2011-10-10 | 2013-04-18 | Basf Plant Science Company Gmbh | Method of producing plants having increased resistance to pathogens |
CA2897482A1 (en) | 2013-01-29 | 2014-08-07 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing hcp7 |
US10231397B2 (en) | 2013-01-29 | 2019-03-19 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing EIN2 |
WO2014117990A1 (en) | 2013-01-29 | 2014-08-07 | Basf Plant Science Company Gmbh | Fungal resistant plants expressing hcp6 |
AR096014A1 (es) | 2013-03-08 | 2015-12-02 | Basf Plant Science Co Gmbh | PLANTAS RESISTENTES A HONGOS QUE EXPRESAN EL FACTOR DE TRANSCRIPCIÓN Myb (MybTF) |
US10907166B2 (en) | 2013-06-17 | 2021-02-02 | Bayer Cropscience Aktiengesellschaft | Method for identifying substances which prime cells for a stress response and cells for use in this method |
BR112016000395B1 (pt) | 2013-07-10 | 2022-12-06 | Basf Se | Molécula de dsrna, sequência de dna, métodos para controlar um fitopatógeno e composição para controlar um fitopatógeno |
CN107429259A (zh) | 2015-02-04 | 2017-12-01 | 巴斯夫植物科学有限公司 | 通过增加莨菪亭含量,增加转基因植物中大豆锈病抗性的方法 |
KR20180021718A (ko) | 2015-05-28 | 2018-03-05 | 트위드 인크. | Thca 신타제의 변형된 발현을 갖는 칸나비스 식물 |
EP3054014A3 (de) | 2016-05-10 | 2016-11-23 | BASF Plant Science Company GmbH | Benutzung einer fungizids auf transgenen pflanzen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4407956A (en) * | 1981-03-13 | 1983-10-04 | The Regents Of The University Of California | Cloned cauliflower mosaic virus DNA as a plant vehicle |
US5034322A (en) * | 1983-01-17 | 1991-07-23 | Monsanto Company | Chimeric genes suitable for expression in plant cells |
ATE80182T1 (de) * | 1985-10-25 | 1992-09-15 | Monsanto Co | Pflanzenvektoren. |
ES2060646T3 (es) * | 1987-02-09 | 1994-12-01 | Lubrizol Genetics Inc | Virus rna hibrido. |
NL9001711A (nl) * | 1989-10-03 | 1991-05-01 | Clovis Matton N V | Genetische manipulaties met recombinant dna, dat van rna virus afgeleide sequenties omvat. |
-
1992
- 1992-07-31 WO PCT/US1992/006359 patent/WO1993003161A1/en active IP Right Grant
- 1992-07-31 AU AU33511/93A patent/AU683412B2/en not_active Ceased
- 1992-07-31 CA CA002114636A patent/CA2114636C/en not_active Expired - Fee Related
- 1992-07-31 EP EP92916441A patent/EP0596979B1/de not_active Expired - Lifetime
- 1992-07-31 DK DK92916441T patent/DK0596979T3/da active
- 1992-07-31 DE DE69232393T patent/DE69232393T2/de not_active Expired - Fee Related
- 1992-07-31 KR KR1019940700361A patent/KR100238904B1/ko not_active IP Right Cessation
- 1992-07-31 AT AT92916441T patent/ATE212671T1/de not_active IP Right Cessation
- 1992-07-31 JP JP4511611A patent/JPH07503361A/ja not_active Withdrawn
- 1992-07-31 ES ES92916441T patent/ES2171398T3/es not_active Expired - Lifetime
-
2000
- 2000-07-12 JP JP2000212070A patent/JP3545683B2/ja not_active Expired - Fee Related
-
2001
- 2001-10-10 JP JP2001313207A patent/JP3316209B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP3545683B2 (ja) | 2004-07-21 |
ES2171398T3 (es) | 2002-09-16 |
DE69232393T2 (de) | 2002-08-29 |
EP0596979B1 (de) | 2002-01-30 |
JP3316209B2 (ja) | 2002-08-19 |
JP2002171976A (ja) | 2002-06-18 |
WO1993003161A1 (en) | 1993-02-18 |
CA2114636A1 (en) | 1993-02-18 |
CA2114636C (en) | 2006-11-28 |
JPH07503361A (ja) | 1995-04-13 |
KR100238904B1 (ko) | 2000-01-15 |
DE69232393D1 (de) | 2002-03-14 |
EP0596979A1 (de) | 1994-05-18 |
DK0596979T3 (da) | 2002-05-13 |
AU3351193A (en) | 1993-03-02 |
AU683412B2 (en) | 1997-11-13 |
EP0596979A4 (en) | 1994-07-13 |
JP2001054394A (ja) | 2001-02-27 |
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