ES2169325T3 - Compuestos peptidos ciclicos para el tratamiento del dolor y procedimiento de produccion de los mismos. - Google Patents

Compuestos peptidos ciclicos para el tratamiento del dolor y procedimiento de produccion de los mismos.

Info

Publication number
ES2169325T3
ES2169325T3 ES97309757T ES97309757T ES2169325T3 ES 2169325 T3 ES2169325 T3 ES 2169325T3 ES 97309757 T ES97309757 T ES 97309757T ES 97309757 T ES97309757 T ES 97309757T ES 2169325 T3 ES2169325 T3 ES 2169325T3
Authority
ES
Spain
Prior art keywords
cyclic peptide
treatment
peptide compounds
same
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97309757T
Other languages
English (en)
Inventor
Hideo Hirai
Nakao Kojima
Hiroyuki Nishida
Toshiyuki Saito
Nobuji Yoshikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2169325T3 publication Critical patent/ES2169325T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

ESTA INVENCION PROPORCIONA UNOS PROCESOS PARA PRODUCIR NOVEDOSOS COMPUESTOS CICLOPEPTIDICOS, QUE COMPRENDEN EL CULTIVO DE CTENOMYCES SERRATUS FERM BP-5731 Y EL SUBSIGUIENTE AISLAMIENTO DE LOS COMPUESTOS CICLOPEPTIDICOS A PARTIR DEL CALDO DE FERMENTACION. LOS COMPUESTOS PRODUCIDOS POR ESTOS PROCESOS INCLUYEN UN COMPUESTO CICLOPEPTIDICO CON LA SIGUIENTE FORMULA (I): LA PRESENTE INVENCION TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE LOS MISMOS, UTIL EN EL TRATAMIENTO DEL DOLOR INTENSO, LA DESINTOXICACION DE LA DEPENDENCIA DE ESTUPEFACIENTES O LA INTOXICACION AGUDA DE ESTUPEFACIENTES O SITUACIONES SIMILARES.
ES97309757T 1996-12-04 1997-12-03 Compuestos peptidos ciclicos para el tratamiento del dolor y procedimiento de produccion de los mismos. Expired - Lifetime ES2169325T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9601352 1996-12-04

Publications (1)

Publication Number Publication Date
ES2169325T3 true ES2169325T3 (es) 2002-07-01

Family

ID=11004499

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97309757T Expired - Lifetime ES2169325T3 (es) 1996-12-04 1997-12-03 Compuestos peptidos ciclicos para el tratamiento del dolor y procedimiento de produccion de los mismos.

Country Status (10)

Country Link
US (1) US5885959A (es)
EP (1) EP0852232B1 (es)
JP (1) JP3521110B2 (es)
AT (1) ATE211484T1 (es)
BR (1) BR9706222A (es)
CA (1) CA2223360C (es)
DE (1) DE69709841T2 (es)
DK (1) DK0852232T3 (es)
ES (1) ES2169325T3 (es)
MX (1) MX9709494A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9709494A (es) * 1996-12-04 1998-07-31 Pfizer Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos.
US7521420B2 (en) 2003-06-18 2009-04-21 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
EP3536335A1 (en) 2014-07-11 2019-09-11 University of Kansas Cyclic tetrapeptide stereoisomers
CN110430889B (zh) * 2017-01-20 2023-09-19 堪萨斯大学 降低c-myc蛋白质水平并减慢癌细胞生长的大环肽
CA3094819A1 (en) 2018-03-23 2019-09-26 University Of Kansas Cyclic tetrapeptide analogs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255224A3 (en) * 1986-06-30 1990-04-18 Merck & Co. Inc. Cyclic and bridged cyclic somatostatin analogs useful as analgesic agents
CA2090171A1 (en) * 1993-02-23 1994-08-24 Peter W. Schiller Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds
US5521156A (en) * 1994-02-03 1996-05-28 Merrell Pharmaceuticals Inc. Cyclic neurokinin A antagonists
IS4261A (is) * 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
MX9709494A (es) * 1996-12-04 1998-07-31 Pfizer Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos.

Also Published As

Publication number Publication date
BR9706222A (pt) 1999-06-01
ATE211484T1 (de) 2002-01-15
US5885959A (en) 1999-03-23
MX9709494A (es) 1998-07-31
DE69709841T2 (de) 2002-08-22
EP0852232B1 (en) 2002-01-02
CA2223360C (en) 2000-05-30
DK0852232T3 (da) 2002-04-22
JPH111492A (ja) 1999-01-06
JP3521110B2 (ja) 2004-04-19
CA2223360A1 (en) 1998-06-04
DE69709841D1 (de) 2002-02-28
EP0852232A1 (en) 1998-07-08

Similar Documents

Publication Publication Date Title
ES2164717T3 (es) Compuestos triciclicos de sulfonamida utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
PT854874E (pt) Compostos de lactona macrociclica e seu processo de producao
DE3587579T2 (de) Pharmazeutische Zubereitung enthaltend eine Tetrahydropyrrolverbindung als aktiven Bestandteil und Verfahren zur Herstellung dieser Tetrapyrrolverbindung.
ES2164718T3 (es) Compuestos triciclicos de amida y urea utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
ATE217635T1 (de) Zyklische peptide mit antifungischer wirkung und verfahren zu ihrer herstellung
DK0462531T3 (da) Cyklisk polypeptid med antibiotisk aktivetet, en fremgangsmåde til fremstilling deraf og en renkultur af en Coelomycetes-stamme
ES2164716T3 (es) Compuestos triciclicos de carbamato utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
EP0885957A4 (en) DEACYLATION PROCESS OF CYCLIC LIPOPEPTIDES
AU5969396A (en) Novel N-(4-oxo-2,3,4,5-tetrahydro-1H-1, 5-benzodiazepin-3yl)-3-amides
ES2169325T3 (es) Compuestos peptidos ciclicos para el tratamiento del dolor y procedimiento de produccion de los mismos.
FI941699A0 (fi) Atsabisyklo-aryyliasetyleeni- ja arylenyynioksiimit kolinenergisina aineina ja hoitomenetelmät
HUT47136A (en) Process for producing cyclic peptides with anticoagulant effect
ATE11217T1 (de) Antibiotische substanzen, verfahren zu deren herstellung und deren zusammensetzungen; stamm von staphylococcus epidermidis, welcher diese antibiotische substanz produziert und deren zusammensetzungen.
DE3870510D1 (de) Tricyclische 5,6,7,8-tetrahydro-naphtho (2,3b)-2,3-dihydrofuran- und 6,7,8,9-tetrahydro-5h-benzocyclohepta (2,3b)-2,3-dihydrofuranaminderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
FR2757159B1 (fr) Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments
Akindele et al. Total synthesis of stylissatin A, a cyclic peptide that inhibits nitric oxide production
Lewis Muscarine, oxazole, and peptide alkaloids and other miscellaneous alkaloids
KR890700131A (ko) 신규 화합물
Kanaoka et al. Syntheses of bassianolide and its two homologs, enniatin C and decabassianolide
BG101939A (en) Method for the preparation of pure isomers of alpha-bis-oximes
MX9707232A (es) Compuestos triciclicos de amida y urea, utiles para la inhibicion de la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.
KR960000870A (ko) 스트렙토마이세스(Streptomyces sp.)속 균주가 생산하는 지질 과산화 저해 활성물질 및 그 제조방법

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 852232

Country of ref document: ES