DE69709841T2 - Zyklische Peptideverbindungen zur Schmerzbehandlung und ihr Herstellungsverfahren - Google Patents

Zyklische Peptideverbindungen zur Schmerzbehandlung und ihr Herstellungsverfahren

Info

Publication number
DE69709841T2
DE69709841T2 DE69709841T DE69709841T DE69709841T2 DE 69709841 T2 DE69709841 T2 DE 69709841T2 DE 69709841 T DE69709841 T DE 69709841T DE 69709841 T DE69709841 T DE 69709841T DE 69709841 T2 DE69709841 T2 DE 69709841T2
Authority
DE
Germany
Prior art keywords
cyclic peptide
peptide compounds
manufacturing process
pain treatment
narcotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69709841T
Other languages
English (en)
Other versions
DE69709841D1 (de
Inventor
Hideo Hirai
Nakao Kojima
Hiroyuki Nishida
Toshiyuki Saito
Nobuji Yoshikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69709841D1 publication Critical patent/DE69709841D1/de
Publication of DE69709841T2 publication Critical patent/DE69709841T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69709841T 1996-12-04 1997-12-03 Zyklische Peptideverbindungen zur Schmerzbehandlung und ihr Herstellungsverfahren Expired - Fee Related DE69709841T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9601352 1996-12-04

Publications (2)

Publication Number Publication Date
DE69709841D1 DE69709841D1 (de) 2002-02-28
DE69709841T2 true DE69709841T2 (de) 2002-08-22

Family

ID=11004499

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69709841T Expired - Fee Related DE69709841T2 (de) 1996-12-04 1997-12-03 Zyklische Peptideverbindungen zur Schmerzbehandlung und ihr Herstellungsverfahren

Country Status (10)

Country Link
US (1) US5885959A (de)
EP (1) EP0852232B1 (de)
JP (1) JP3521110B2 (de)
AT (1) ATE211484T1 (de)
BR (1) BR9706222A (de)
CA (1) CA2223360C (de)
DE (1) DE69709841T2 (de)
DK (1) DK0852232T3 (de)
ES (1) ES2169325T3 (de)
MX (1) MX9709494A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9709494A (es) * 1996-12-04 1998-07-31 Pfizer Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos.
US7521420B2 (en) 2003-06-18 2009-04-21 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor
EP3536335A1 (de) 2014-07-11 2019-09-11 University of Kansas Cyclische tetrapeptidstereoisomere
CN110430889B (zh) * 2017-01-20 2023-09-19 堪萨斯大学 降低c-myc蛋白质水平并减慢癌细胞生长的大环肽
CA3094819A1 (en) 2018-03-23 2019-09-26 University Of Kansas Cyclic tetrapeptide analogs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255224A3 (de) * 1986-06-30 1990-04-18 Merck & Co. Inc. Cyclische und verbrückt cyclische Analoge von Somatostatin, verwendbar als analgetische Arzneimittel
CA2090171A1 (en) * 1993-02-23 1994-08-24 Peter W. Schiller Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds
US5521156A (en) * 1994-02-03 1996-05-28 Merrell Pharmaceuticals Inc. Cyclic neurokinin A antagonists
IS4261A (is) * 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
MX9709494A (es) * 1996-12-04 1998-07-31 Pfizer Compuestos peptidicos ciclicos, procedimiento para su produccion, composiciones que los contienen y uso de los mismos.

Also Published As

Publication number Publication date
BR9706222A (pt) 1999-06-01
ATE211484T1 (de) 2002-01-15
US5885959A (en) 1999-03-23
MX9709494A (es) 1998-07-31
EP0852232B1 (de) 2002-01-02
CA2223360C (en) 2000-05-30
DK0852232T3 (da) 2002-04-22
ES2169325T3 (es) 2002-07-01
JPH111492A (ja) 1999-01-06
JP3521110B2 (ja) 2004-04-19
CA2223360A1 (en) 1998-06-04
DE69709841D1 (de) 2002-02-28
EP0852232A1 (de) 1998-07-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee