DE69923460D1 - Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen - Google Patents

Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen

Info

Publication number
DE69923460D1
DE69923460D1 DE69923460T DE69923460T DE69923460D1 DE 69923460 D1 DE69923460 D1 DE 69923460D1 DE 69923460 T DE69923460 T DE 69923460T DE 69923460 T DE69923460 T DE 69923460T DE 69923460 D1 DE69923460 D1 DE 69923460D1
Authority
DE
Germany
Prior art keywords
ring
cyclic peptide
new
production
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69923460T
Other languages
English (en)
Other versions
DE69923460T2 (de
Inventor
Stanley Borromeo
Daniel Cohen
Stuart Gregory
Kay Henle
Andrew Hitchcock
Nickolaus Jungheim
Ray Mayhugh
Alan Shepherd
Wilson Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69923460D1 publication Critical patent/DE69923460D1/de
Publication of DE69923460T2 publication Critical patent/DE69923460T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69923460T 1998-08-20 1999-08-18 Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen Expired - Fee Related DE69923460T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9722898P 1998-08-20 1998-08-20
US97228P 1998-08-20
PCT/US1999/018908 WO2000011023A2 (en) 1998-08-20 1999-08-18 Ring modified cyclic peptide analogs

Publications (2)

Publication Number Publication Date
DE69923460D1 true DE69923460D1 (de) 2005-03-03
DE69923460T2 DE69923460T2 (de) 2007-01-11

Family

ID=22262272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69923460T Expired - Fee Related DE69923460T2 (de) 1998-08-20 1999-08-18 Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen

Country Status (11)

Country Link
US (2) US6653281B1 (de)
EP (1) EP1107981B1 (de)
JP (1) JP2002528388A (de)
AT (1) ATE287899T1 (de)
AU (1) AU765660B2 (de)
CA (1) CA2340676A1 (de)
DE (1) DE69923460T2 (de)
DK (1) DK1107981T3 (de)
ES (1) ES2233070T3 (de)
PT (1) PT1107981E (de)
WO (1) WO2000011023A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
CA2340676A1 (en) 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
RU2001118849A (ru) 1998-12-09 2003-08-10 Эли Лилли энд Компани (US) Очистка циклопептидных соединений эхинокандина
JP4936595B2 (ja) 1999-03-03 2012-05-23 イーライ リリー アンド カンパニー ミセル形成界面活性剤を含有するエキノカンジン薬学的処方物
KR20020002476A (ko) 1999-03-03 2002-01-09 피터 지. 스트링거 결정질 에키노칸딘 암모늄염의 형성 및 음이온 교환
EP1156784A1 (de) 1999-03-03 2001-11-28 Eli Lilly And Company Verfahren zur herstellung pharmazeutischen oralen ecb zubereitungen und zusammensetzungen
ES2204548T3 (es) 1999-03-03 2004-05-01 Eli Lilly And Company Complejos de equinocandina/carbohidrato.
TWI232102B (en) 2001-07-17 2005-05-11 Shionogi & Co A pharmaceutical formulation for injection
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP2488492B1 (de) * 2009-10-14 2016-01-13 Dana-Farber Cancer Institute, Inc. Geschützte aminmarkierungen und ihre verwendung beim nachweis von analyten
PL243656B1 (pl) * 2018-05-30 2023-09-25 Boruta Zachem Biochemia Spolka Z Ograniczona Odpowiedzialnoscia Sposób usuwania lipopeptydów z roztworów i zmiana ich struktury
BR112022026364A2 (pt) * 2020-06-23 2023-01-17 Genentech Inc Composto macrocíclico, compostos, complexo, uso de um composto, composição farmacêutica, métodos para tratar câncer e para tratar uma condição fibrótica e invenção

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293489A (en) 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4320052A (en) 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
DK173802B1 (da) 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
US5049546A (en) 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
US5330973A (en) 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
IL97347A0 (en) 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5386009A (en) 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
US5310726A (en) 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IE990233A1 (en) 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
US5337405A (en) 1990-10-02 1994-08-09 Hewlett-Packard Company Guided data presentation
US5369093A (en) 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
MY136593A (en) 1992-03-19 2008-10-31 Lilly Co Eli Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US5541160A (en) 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5646111A (en) 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
WO1996035712A1 (en) 1995-05-10 1996-11-14 Chiroscience Limited Peptidyl compounds which inhibit metalloproteinase and tnf liberation and their therapeutic use
US5652213A (en) 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5629290A (en) 1995-05-26 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
US5786325A (en) 1995-05-26 1998-07-28 Eli Lilly And Company Cyclic peptide antifungal agents and methods of making and using
US5618787A (en) 1995-05-26 1997-04-08 Eli Lilly And Company Cyclic peptide antifungal agents
US5629289A (en) 1995-07-25 1997-05-13 Eli Lilly And Company Cyclic peptide antifungal agents
WO1997027864A1 (en) 1996-02-01 1997-08-07 Eli Lilly And Company Cyclic peptide antifungal agents
US5696084A (en) 1996-08-16 1997-12-09 Abbott Laboratories Amino-lipopetide antifungal agents
AU8687798A (en) 1997-08-04 1999-02-22 Eli Lilly And Company Cyclic peptide antifungal agents
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
CA2340676A1 (en) * 1998-08-20 2000-03-02 Eli Lilly And Company Ring modified cyclic peptide analogs
WO2000012540A1 (en) 1998-08-28 2000-03-09 Eli Lilly And Company Reversible boronate complexes of 1,2-cis-diol cyclic-peptides
AU2189500A (en) 1998-12-16 2000-07-03 Eli Lilly And Company Cyclic peptide antifungal agents having a sugar substituent
AU767357B2 (en) 1998-12-16 2003-11-06 Eli Lilly And Company Cyclic peptide antifungal agents

Also Published As

Publication number Publication date
EP1107981B1 (de) 2005-01-26
PT1107981E (pt) 2005-05-31
ATE287899T1 (de) 2005-02-15
DK1107981T3 (da) 2005-05-30
WO2000011023A3 (en) 2000-06-15
US6939946B2 (en) 2005-09-06
WO2000011023A2 (en) 2000-03-02
EP1107981A2 (de) 2001-06-20
ES2233070T3 (es) 2005-06-01
JP2002528388A (ja) 2002-09-03
US20040068094A1 (en) 2004-04-08
DE69923460T2 (de) 2007-01-11
CA2340676A1 (en) 2000-03-02
US6653281B1 (en) 2003-11-25
AU5572699A (en) 2000-03-14
AU765660B2 (en) 2003-09-25

Similar Documents

Publication Publication Date Title
DE69923460D1 (de) Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
DE50213524D1 (de) Kationische sterolderivate, ph-sensitive liposomen diese umfassend und verfahren zur wirkstoffbeladung von liposomen
DE69636147D1 (de) Verfahren zur herstellung von phosphorothioat-oligomeren
ATE215612T1 (de) Methode zur dissoziation von biotin komplexen
AR056723A2 (es) Polipeptido purificado metodo para producirlo , metodo para identificarlo y/ o aislarlo composicion farmaceutica que lo comprende, secuencia de acidos nucleicos aislada que codifica dicho polipeptido, vector que contiene a dicha secuencia celula huesped transfectada por dicho vector, sonda nucleotid
DE69613333D1 (de) Verfahren zur Herstellung von Kathodenmischungen für Batterien
ATE266030T1 (de) 1,4,7,10-tetraazabicyclo(8.2.2)tetradecan-2-on, verfahren zu ihrer herstellung und ihrer verwendung für die herstellung von tetraazamacrocyclen
DE59601745D1 (de) Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin
DE60023860D1 (de) Verfahren zur herstellung von rekombinanten peptiden
DE59602230D1 (de) Verfahren zur Herstellung von 2,2-Difluorbenzo[1.3]dioxolcarbaldehyden
ATE153073T1 (de) Verfahren zur herstellung von n- acetylneuraminsäure
ATE190974T1 (de) Verfahren zur herstellung von n,n'- disubstituierten cyclischen harnstoffen
DE69736389T8 (de) Proteine mit zellulase-aktivitäten und prozess für ihre herstellung
DE69735583D1 (de) Semisynthetisches verfahren zur herstellung von didemninanalogen
DE69836496D1 (de) Verfahren zur herstellung von beta-(1,3)-d-glukan aus pilzen
DE60126802D1 (de) Cyclopeptide, verfahren zu ihrer herstellung und ihre verwendung zur hemmung oder stimulierung von angiogenese
ATE287879T1 (de) Verfahren zur herstellung von isoflavonen
ATE298747T1 (de) Verfahren zur herstellung von 5- hydroxybenzo(b)thiophen-3-carbonsäure
FI973469A (fi) Menetelmä tekijän IX valmistamiseksi biologisista lähteistä
DE69626738D1 (de) Verfahren zur Herstellung von Polyamiden aus Caprolactam
DE68912809D1 (de) Verfahren zur Herstellung von Bis(2,2,6,6-tetramethyl-4-piperidyl)amin.
DE69623635D1 (de) Mu-opioidligande: agonisten und antagonisten
NO20004613L (no) FremgangsmÕte for fremstilling av et tetrapeptid
DE59500920D1 (de) Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin
DE59603908D1 (de) Verfahren zur Herstellung von N',N'-disubstituierten 1,4-Diaminoanthrachinonen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee