ES2166269A1 - Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol. - Google Patents

Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol.

Info

Publication number
ES2166269A1
ES2166269A1 ES009901579A ES9901579A ES2166269A1 ES 2166269 A1 ES2166269 A1 ES 2166269A1 ES 009901579 A ES009901579 A ES 009901579A ES 9901579 A ES9901579 A ES 9901579A ES 2166269 A1 ES2166269 A1 ES 2166269A1
Authority
ES
Spain
Prior art keywords
compounds
radical
replacement
alkoxide
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009901579A
Other languages
English (en)
Other versions
ES2166269B1 (es
Inventor
Gomez Antonio Cosme
De Casa-Juana Munoz Miguel Fau
Vintro Jose Maria Gelpi
Ponce Andres Molina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quimica Sintetica SA
Original Assignee
Quimica Sintetica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quimica Sintetica SA filed Critical Quimica Sintetica SA
Priority to ES009901579A priority Critical patent/ES2166269B1/es
Priority to AU55588/00A priority patent/AU5558800A/en
Priority to PCT/IB2000/000927 priority patent/WO2001004109A1/en
Priority to EG20000903A priority patent/EG23175A/xx
Priority to SV2000000126A priority patent/SV2002000126A/es
Priority to TNTNSN00153A priority patent/TNSN00153A1/fr
Publication of ES2166269A1 publication Critical patent/ES2166269A1/es
Application granted granted Critical
Publication of ES2166269B1 publication Critical patent/ES2166269B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nuevo procedimiento de obtención de derivados de 2-(2- piridinilmetilsulfinil)-1H-benzimidazol Procedimiento de obtención de un derivado de 2-(2-piridinilmetilsulfinil)-1H- benzimidazol de fórmula general (I), donde R = H; R'' = 3- Metoxipropil, R" = metilo; R'''''' = H, caracterizado porque se lleva a cabo mediante la substitución de un halógeno en la posición 4 del anillo de piridina de los compuestos de fórmula general (VIII) por 3-Metoxipropanol en presencia de una base y en el seno de un disolvente polar aprótico. Es útil en el tratamiento o prevención de las úlceras pépticas.
ES009901579A 1999-07-14 1999-07-14 Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol. Expired - Fee Related ES2166269B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES009901579A ES2166269B1 (es) 1999-07-14 1999-07-14 Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol.
AU55588/00A AU5558800A (en) 1999-07-14 2000-07-10 Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles
PCT/IB2000/000927 WO2001004109A1 (en) 1999-07-14 2000-07-10 Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles
EG20000903A EG23175A (en) 1999-07-14 2000-07-12 New procedure for obtaining derivatives of 2-(2-(pyridinylmethylsulphinyl)-1H-benzimidazole)
SV2000000126A SV2002000126A (es) 1999-07-14 2000-07-13 Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol ref. a-149206
TNTNSN00153A TNSN00153A1 (fr) 1999-07-14 2000-07-31 Nouveau procede d'obtention de derives de 2-(2- pyridinylmethylsulfinyle)-1h-benzimido-azol

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901579A ES2166269B1 (es) 1999-07-14 1999-07-14 Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol.

Publications (2)

Publication Number Publication Date
ES2166269A1 true ES2166269A1 (es) 2002-04-01
ES2166269B1 ES2166269B1 (es) 2003-04-01

Family

ID=8309223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009901579A Expired - Fee Related ES2166269B1 (es) 1999-07-14 1999-07-14 Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol.

Country Status (6)

Country Link
AU (1) AU5558800A (es)
EG (1) EG23175A (es)
ES (1) ES2166269B1 (es)
SV (1) SV2002000126A (es)
TN (1) TNSN00153A1 (es)
WO (1) WO2001004109A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2264362A1 (es) * 2004-12-22 2006-12-16 Laboratorios Viñas S.A. "procedimiento para la obtencion de derivados de 2-(2-piridinilmetilsufinil-1h-benzimidazoles".
ES2273564A1 (es) * 2005-03-22 2007-05-01 Quimica Sintetica, S.A. Procedimiento para la preparacion de pantoprazol.

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2187248B1 (es) * 2000-08-25 2004-01-16 Sint Quimica Sa Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol.
ES2185459B1 (es) * 2000-10-02 2003-12-16 Dinamite Dipharma Spa Procedimiento para la obtencion de pantoprazol y compuestos intermedios para el mismo.
AU2003237598A1 (en) * 2002-06-03 2003-12-19 Aurobindo Pharma Ltd. Process for the preparation of highly pure rabeprazole sodium salt
WO2004056804A2 (en) 2002-12-19 2004-07-08 Teva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
AU2003288703A1 (en) * 2003-12-05 2005-06-24 Hetero Drugs Limited A process for the preparation of substitited pyridinylmethylsulfinyl- benzimidazole enantiomers
SE0400410D0 (sv) 2004-02-20 2004-02-20 Astrazeneca Ab New compounds
JP4884967B2 (ja) * 2004-06-30 2012-02-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンズイミダゾール誘導体塩沈殿物の製造方法
JP5355893B2 (ja) * 2004-12-16 2013-11-27 シプラ・リミテッド パントプラゾールナトリウムの製造方法
DE602006015287D1 (de) * 2005-02-21 2010-08-19 Cipla Ltd Neues verfahren zur synthese von protonenpumpenhemmern
MX2007011967A (es) * 2005-03-30 2007-12-10 Lupin Ltd Un proceso mejorado para la fabricacion de rabeprazol sodico.
MX2010010049A (es) * 2008-03-18 2010-10-04 Reddys Lab Ltd Dr Proceso y polimorfos de dexlansoprazol.
EP2585450A1 (en) 2010-06-24 2013-05-01 Cilpa Limited Salts and polymorphs of dexrabeprazole
CN102993181B (zh) * 2012-12-26 2014-07-23 山东大学 埃索美拉唑的制备方法及埃索美拉唑盐的制备方法
CN104098516B (zh) * 2013-04-15 2016-12-28 北大方正集团有限公司 一种用于制备埃索美拉唑或其钠盐的中间体及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023609A6 (es) * 1990-11-29 1992-01-16 Inke Sa Procedimiento para la obtencion del 2-(((3-metil -4-(2,2,2-trifluoroetoxi) -2-piridinil) metilisulfinil) -1h-bemzimidazol.
ES2036948A1 (es) * 1991-11-21 1993-06-01 Genesis Para La Investigacion Procedimiento de obtencion de compuestos derivados de piridina.
ES2037609A1 (es) * 1991-12-02 1993-06-16 Techquin Etablissment Procedimiento para la obtencion del 2-(((3-metil-4-(2,2,2-trifluroetoxi)-2-piridinil)-metil)sulfinil)-1h-benzimidazol.
ES2060541A1 (es) * 1993-02-26 1994-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2037608B1 (es) * 1991-12-02 1994-04-01 Techquin Etablissment Procedimiento para la obtencion del 2 (((3-metil-4-(2,2,2,-trifluoroetoxi)-2-piridinil)-metil)sulfinil)-1h-benzimidazol".

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2023609A6 (es) * 1990-11-29 1992-01-16 Inke Sa Procedimiento para la obtencion del 2-(((3-metil -4-(2,2,2-trifluoroetoxi) -2-piridinil) metilisulfinil) -1h-bemzimidazol.
ES2036948A1 (es) * 1991-11-21 1993-06-01 Genesis Para La Investigacion Procedimiento de obtencion de compuestos derivados de piridina.
ES2037609A1 (es) * 1991-12-02 1993-06-16 Techquin Etablissment Procedimiento para la obtencion del 2-(((3-metil-4-(2,2,2-trifluroetoxi)-2-piridinil)-metil)sulfinil)-1h-benzimidazol.
ES2060541A1 (es) * 1993-02-26 1994-11-16 Vinas Lab Nuevo procedimiento para la sintesis de un derivado de 2-(2-piridilmetilsufinil) bencimidazol, y nuevos productos intermedios obtenidos con el mismo.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAPPE C.O. et KAPPE T.: "Synthesis of Substituted 3-Pyridinecarbonitriles with Potential Biological Activity" MONATSHEFTE CHEMIE, vol. 120, no. 12, 1989, pages 1095-1100 *
MITTELBACH M. ET AL.: "Synthesis of 4-Methoxy-2,3,5-trimethylpyridine: a Specific Building Block for Compounds with Gastric-acid Inhibiting Activity" ACTA CHEM. SCAND. SER. B, vol. 42, no. 8, 1988, pages 524-529 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2264362A1 (es) * 2004-12-22 2006-12-16 Laboratorios Viñas S.A. "procedimiento para la obtencion de derivados de 2-(2-piridinilmetilsufinil-1h-benzimidazoles".
ES2273564A1 (es) * 2005-03-22 2007-05-01 Quimica Sintetica, S.A. Procedimiento para la preparacion de pantoprazol.
ES2273564B1 (es) * 2005-03-22 2008-04-01 Quimica Sintetica, S.A. Procedimiento para la preparacion de pantoprazol.

Also Published As

Publication number Publication date
EG23175A (en) 2004-06-30
TNSN00153A1 (fr) 2002-05-30
SV2002000126A (es) 2002-02-05
AU5558800A (en) 2001-01-30
ES2166269B1 (es) 2003-04-01
WO2001004109A1 (en) 2001-01-18

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