CN104098516B - 一种用于制备埃索美拉唑或其钠盐的中间体及其制备方法 - Google Patents
一种用于制备埃索美拉唑或其钠盐的中间体及其制备方法 Download PDFInfo
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- CN104098516B CN104098516B CN201310129881.2A CN201310129881A CN104098516B CN 104098516 B CN104098516 B CN 104098516B CN 201310129881 A CN201310129881 A CN 201310129881A CN 104098516 B CN104098516 B CN 104098516B
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- 0 C[C@](*)(OS(c1nc2cc(OC)ccc2[n]1)=O)[S@@](C(I=CC=C)=C)=CC=C Chemical compound C[C@](*)(OS(c1nc2cc(OC)ccc2[n]1)=O)[S@@](C(I=CC=C)=C)=CC=C 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (27)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310129881.2A CN104098516B (zh) | 2013-04-15 | 2013-04-15 | 一种用于制备埃索美拉唑或其钠盐的中间体及其制备方法 |
Applications Claiming Priority (1)
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CN201310129881.2A CN104098516B (zh) | 2013-04-15 | 2013-04-15 | 一种用于制备埃索美拉唑或其钠盐的中间体及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN104098516A CN104098516A (zh) | 2014-10-15 |
CN104098516B true CN104098516B (zh) | 2016-12-28 |
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CN201310129881.2A Active CN104098516B (zh) | 2013-04-15 | 2013-04-15 | 一种用于制备埃索美拉唑或其钠盐的中间体及其制备方法 |
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CN (1) | CN104098516B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105669648A (zh) * | 2014-11-21 | 2016-06-15 | 北大方正集团有限公司 | 一种高纯度埃索美拉唑钠的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001004109A1 (en) * | 1999-07-14 | 2001-01-18 | Quimica Sintetica, S.A. | Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles |
ES2187248B1 (es) * | 2000-08-25 | 2004-01-16 | Sint Quimica Sa | Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol. |
WO2008142006A1 (en) * | 2007-05-18 | 2008-11-27 | Chemo Ibérica, S.A. | Process for preparing 2-(2-pyridylmethyl)-sulfinyl-1h-benzimidazoles and the intermediate compounds used therein |
CN102603621A (zh) * | 2012-02-07 | 2012-07-25 | 成都苑东药业有限公司 | 一种新型手性亚砜化合物和以该化合物制备埃索美拉唑钠的方法 |
CN102816149A (zh) * | 2011-06-10 | 2012-12-12 | 上海汇伦生命科技有限公司 | 一种高对映选择性合成(s)-奥美拉唑及其盐的制备方法 |
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2013
- 2013-04-15 CN CN201310129881.2A patent/CN104098516B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001004109A1 (en) * | 1999-07-14 | 2001-01-18 | Quimica Sintetica, S.A. | Process for the production of 2-(2-pyridinylmethylsulphinyl)-1h-benzimidazoles |
ES2187248B1 (es) * | 2000-08-25 | 2004-01-16 | Sint Quimica Sa | Nuevo procedimiento de obtencion de derivados de 2-(2-piridinilmetilsulfinil)-1h-benzimidazol. |
WO2008142006A1 (en) * | 2007-05-18 | 2008-11-27 | Chemo Ibérica, S.A. | Process for preparing 2-(2-pyridylmethyl)-sulfinyl-1h-benzimidazoles and the intermediate compounds used therein |
CN102816149A (zh) * | 2011-06-10 | 2012-12-12 | 上海汇伦生命科技有限公司 | 一种高对映选择性合成(s)-奥美拉唑及其盐的制备方法 |
CN102603621A (zh) * | 2012-02-07 | 2012-07-25 | 成都苑东药业有限公司 | 一种新型手性亚砜化合物和以该化合物制备埃索美拉唑钠的方法 |
Non-Patent Citations (3)
Title |
---|
"Design and Synthesis of Chiral Oxathiozinone Scaffolds: Efficient Synthesis of Hindered Enantiopure Sulfinamides and Sulfinyl Ketimines";Zhengxu S. Han等;《Angew. Chem. Int. Ed.》;20130624;第52卷;Supporting Information,第S3页 * |
"Direct Conversion of Thiols to Sulfinyl Chlorides by Sulfuryl Choride";Joo-Hack Youn等;《Synthesis》;19871231(第1期);第72页General Procedure, Table * |
"埃索美拉唑合成路线图解";顾维钧等;《中国医药工业杂志》;20110410;第42卷(第4期);第308-311页 * |
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CN104098516A (zh) | 2014-10-15 |
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Address after: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: PKUCARE PHARMACEUTICAL R&D CENTER Patentee after: PKU HEALTHCARE INDUSTRY Group Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: SOUTHWEST SYNTHETIC PHARMACEUTICAL Corp.,Ltd. Patentee before: PKUCARE PHARMACEUTICAL R&D CENTER Patentee before: Pku Healthcare Industry Group Co.,Ltd. |
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Effective date of registration: 20221013 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: PKUCARE PHARMACEUTICAL R&D CENTER Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District, Cheng Fu Road, No. 298, Zhongguancun Fangzheng building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: PKU HEALTHCARE Corp.,Ltd. Patentee before: PKUCARE PHARMACEUTICAL R&D CENTER Patentee before: PKU HEALTHCARE INDUSTRY Group |
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