JPS6422873A - 1,4-benzoxazine derivative - Google Patents
1,4-benzoxazine derivativeInfo
- Publication number
- JPS6422873A JPS6422873A JP17785087A JP17785087A JPS6422873A JP S6422873 A JPS6422873 A JP S6422873A JP 17785087 A JP17785087 A JP 17785087A JP 17785087 A JP17785087 A JP 17785087A JP S6422873 A JPS6422873 A JP S6422873A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- expressed
- methoxy
- benzoxazine
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:1,4-Benzoxazine derivatives expressed by formula I (R<1> is lower alkyl; R<2> is H or methoxy; n is 0 or 1). EXAMPLE:3,4-Dihydro-5-(5-methoxy-2-benzimidazolylthiomethyl)-4-methyl- 2H-1,4- benzoxazine. USE:Having inhibitory action on gastric acid secretion and powerful gastric mucosal protective action and useful as a remedy for peptic ulcer. PREPARATION:As shown in the reaction formulas, 1,4-benzoxazines expressed by formula II (X is halogen) are reacted with 2-mercaptobenzimidazoles expressed by formula III in the presence of a base, such as NaOH, in a solvent, such as methanol, to provide a compound expressed by formula I (n is 0) in the compounds expressed by formula I. Furthermore, the resultant compound is oxidized with a peracid, such as hydrogen peroxide, in a solvent at -15-+10 deg.C to afford the aimed compound expressed by formula I (n is 1) in the compounds expressed by formula I.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17785087A JPS6422873A (en) | 1987-07-16 | 1987-07-16 | 1,4-benzoxazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17785087A JPS6422873A (en) | 1987-07-16 | 1987-07-16 | 1,4-benzoxazine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6422873A true JPS6422873A (en) | 1989-01-25 |
Family
ID=16038194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17785087A Pending JPS6422873A (en) | 1987-07-16 | 1987-07-16 | 1,4-benzoxazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6422873A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0402859A2 (en) * | 1989-06-13 | 1990-12-19 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agents of metabolic bone disease |
-
1987
- 1987-07-16 JP JP17785087A patent/JPS6422873A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0402859A2 (en) * | 1989-06-13 | 1990-12-19 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agents of metabolic bone disease |
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