JPS6422873A - 1,4-benzoxazine derivative - Google Patents

1,4-benzoxazine derivative

Info

Publication number
JPS6422873A
JPS6422873A JP17785087A JP17785087A JPS6422873A JP S6422873 A JPS6422873 A JP S6422873A JP 17785087 A JP17785087 A JP 17785087A JP 17785087 A JP17785087 A JP 17785087A JP S6422873 A JPS6422873 A JP S6422873A
Authority
JP
Japan
Prior art keywords
formula
expressed
methoxy
benzoxazine
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17785087A
Other languages
Japanese (ja)
Inventor
Sachio Ono
Osamu Otani
Seishi Mizukoshi
Osamu Komatsu
Yoshiki Nakamura
Yasuo Kuno
Takao Sugiura
Masasue Kagami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maruko Pharmaceutical Co Ltd
Original Assignee
Maruko Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maruko Pharmaceutical Co Ltd filed Critical Maruko Pharmaceutical Co Ltd
Priority to JP17785087A priority Critical patent/JPS6422873A/en
Publication of JPS6422873A publication Critical patent/JPS6422873A/en
Pending legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:1,4-Benzoxazine derivatives expressed by formula I (R<1> is lower alkyl; R<2> is H or methoxy; n is 0 or 1). EXAMPLE:3,4-Dihydro-5-(5-methoxy-2-benzimidazolylthiomethyl)-4-methyl- 2H-1,4- benzoxazine. USE:Having inhibitory action on gastric acid secretion and powerful gastric mucosal protective action and useful as a remedy for peptic ulcer. PREPARATION:As shown in the reaction formulas, 1,4-benzoxazines expressed by formula II (X is halogen) are reacted with 2-mercaptobenzimidazoles expressed by formula III in the presence of a base, such as NaOH, in a solvent, such as methanol, to provide a compound expressed by formula I (n is 0) in the compounds expressed by formula I. Furthermore, the resultant compound is oxidized with a peracid, such as hydrogen peroxide, in a solvent at -15-+10 deg.C to afford the aimed compound expressed by formula I (n is 1) in the compounds expressed by formula I.
JP17785087A 1987-07-16 1987-07-16 1,4-benzoxazine derivative Pending JPS6422873A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17785087A JPS6422873A (en) 1987-07-16 1987-07-16 1,4-benzoxazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17785087A JPS6422873A (en) 1987-07-16 1987-07-16 1,4-benzoxazine derivative

Publications (1)

Publication Number Publication Date
JPS6422873A true JPS6422873A (en) 1989-01-25

Family

ID=16038194

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17785087A Pending JPS6422873A (en) 1987-07-16 1987-07-16 1,4-benzoxazine derivative

Country Status (1)

Country Link
JP (1) JPS6422873A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402859A2 (en) * 1989-06-13 1990-12-19 Kyorin Pharmaceutical Co., Ltd. Therapeutic agents of metabolic bone disease

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402859A2 (en) * 1989-06-13 1990-12-19 Kyorin Pharmaceutical Co., Ltd. Therapeutic agents of metabolic bone disease

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