ES2163613T3 - Derivados hidrofobos de taxano. - Google Patents
Derivados hidrofobos de taxano.Info
- Publication number
- ES2163613T3 ES2163613T3 ES96903428T ES96903428T ES2163613T3 ES 2163613 T3 ES2163613 T3 ES 2163613T3 ES 96903428 T ES96903428 T ES 96903428T ES 96903428 T ES96903428 T ES 96903428T ES 2163613 T3 ES2163613 T3 ES 2163613T3
- Authority
- ES
- Spain
- Prior art keywords
- derivative
- taxane
- carrier
- derivatives
- animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 6
- 241001465754 Metazoa Species 0.000 abstract 3
- 230000002209 hydrophobic effect Effects 0.000 abstract 3
- 150000002632 lipids Chemical class 0.000 abstract 3
- 229940123237 Taxane Drugs 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ESTA INVENCION SE REFIERE A UN DERIVADO DE TAXANO DE FORMULA (I), EN LA QUE UN RADICAL ORGANICO HIDROFOBO SE ENCUENTRA UNIDO A UN TAXANO. R Y R{SUP,1} SON CADA UNO INDEPENDIENTEMENTE H, O UN RADICAL ORGANICO HIDROFOBO, SIEMPRE QUE AL MENOS UNO DE LOS R Y R{SUP,1} NO ES H. LA UNION DE UN RADICAL ORGANICO HIDROFOBO AL TAXANO, CON EL FIN DE OBTENER UN DERIVADO DE TAXANO EN GENERAL ESTABILIZA LA ASOCIACION DEL DERIVADO CON UN LIPIDO, INCLUYENDO UN LIPIDO LIPOSOMICO, QUE CONSTITUYE UN VEHICULO EN EL PLASMA DE ANIMALES A LOS CUALES SE LES ADMINISTRA LA ASOCIACION DERIVADOVEHICULO. TAMBIEN SE PRESENTA UNA COMPOSICION QUE CONTIENE EL DERIVADO DE TAXANO Y UN MEDIO FARMACEUTICAMENTE ACEPTABLE; DE FORMA PREFERENTE, EL MEDIO TAMBIEN CONTIENE UN VEHICULO LIPIDICO, Y EL DERIVADO SE ASOCIA CON EL VEHICULO. TAMBIEN SE PRESENTA UN PROCEDIMIENTO PARA ADMINISTRAR LOS DERIVADOS DE TAXANO A ANIMALES, POR EJEMPLO, A ANIMALES QUE PADECEN CANCERES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36981795A | 1995-01-09 | 1995-01-09 | |
US08/474,888 US5580899A (en) | 1995-01-09 | 1995-06-07 | Hydrophobic taxane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2163613T3 true ES2163613T3 (es) | 2002-02-01 |
Family
ID=27004714
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00121129T Expired - Lifetime ES2154622T3 (es) | 1995-01-09 | 1996-01-11 | Derivados hidrofobos de taxano. |
ES96903428T Expired - Lifetime ES2163613T3 (es) | 1995-01-09 | 1996-01-11 | Derivados hidrofobos de taxano. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00121129T Expired - Lifetime ES2154622T3 (es) | 1995-01-09 | 1996-01-11 | Derivados hidrofobos de taxano. |
Country Status (13)
Country | Link |
---|---|
US (4) | US5580899A (es) |
EP (2) | EP0802911B1 (es) |
JP (1) | JPH11500712A (es) |
KR (1) | KR100386002B1 (es) |
AT (2) | ATE209196T1 (es) |
AU (1) | AU691401B2 (es) |
CA (1) | CA2209001C (es) |
DE (3) | DE1063234T1 (es) |
DK (2) | DK1063234T3 (es) |
ES (2) | ES2154622T3 (es) |
GR (1) | GR20010300005T1 (es) |
PT (2) | PT1063234E (es) |
WO (1) | WO1996021658A1 (es) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030068362A1 (en) * | 1993-02-22 | 2003-04-10 | American Bioscience, Inc. | Methods and formulations for the delivery of pharmacologically active agents |
US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
ATE309235T1 (de) * | 1995-09-12 | 2005-11-15 | Zeneus Pharma Ltd | Hydrolyse-einleitende hydrophobe taxane derivate |
US6107332A (en) | 1995-09-12 | 2000-08-22 | The Liposome Company, Inc. | Hydrolysis-promoting hydrophobic taxane derivatives |
EP1229030B1 (en) * | 1995-09-12 | 2005-11-09 | Zeneus Pharma Limited | Hydrolysis-promoting taxane hydrophobic derivates |
US6667053B1 (en) * | 1996-02-16 | 2003-12-23 | Elan Pharmaceuticals, Inc. | D and L etherlipid stereoisomers and liposomes |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
JP4172726B2 (ja) * | 1996-05-22 | 2008-10-29 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | シス―ドコサヘキサエン酸とドセタキセルとの共有複合体を含有する製剤 |
US6576636B2 (en) | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
DE69734060T2 (de) | 1996-05-24 | 2006-06-29 | Angiotech Pharmaceuticals, Inc., Vancouver | Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege |
GB2321455A (en) * | 1997-01-24 | 1998-07-29 | Norsk Hydro As | Lipophilic derivatives of biologically active compounds |
US5837283A (en) * | 1997-03-12 | 1998-11-17 | The Regents Of The University Of California | Cationic lipid compositions targeting angiogenic endothelial cells |
US7112338B2 (en) * | 1997-03-12 | 2006-09-26 | The Regents Of The University Of California | Cationic liposome delivery of taxanes to angiogenic blood vessels |
US6136988A (en) | 1998-04-10 | 2000-10-24 | Hauser, Inc. | 7-hexanoyltaxol and methods for preparing the same |
US6461637B1 (en) * | 2000-09-01 | 2002-10-08 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
US6146659A (en) * | 1998-07-01 | 2000-11-14 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
US7314637B1 (en) | 1999-06-29 | 2008-01-01 | Neopharm, Inc. | Method of administering liposomal encapsulated taxane |
US6136989A (en) * | 1998-12-30 | 2000-10-24 | Phytogen Life Sciences, Incorporated | Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material |
IL145069A0 (en) * | 1999-02-23 | 2002-06-30 | Angiotech Pharm Inc | Pharmaceutical compositions for delivery to an external wall of a body passageway or cavity |
WO2000050059A1 (en) * | 1999-02-24 | 2000-08-31 | The Uab Research Foundation | Taxane derivatives for targeted therapy of cancer |
CN1377282A (zh) * | 1999-03-09 | 2002-10-30 | 普罗塔盖公司 | 脂肪酸-抗癌缀合物及其应用 |
US7235583B1 (en) | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
AU4834200A (en) * | 1999-05-10 | 2000-11-21 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
JP4848113B2 (ja) * | 1999-09-09 | 2011-12-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 血管新生血管に対するタキサンの陽イオン性リポソーム送達 |
EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
US6362217B2 (en) * | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
AU2002305099A1 (en) | 2001-03-23 | 2002-10-08 | Protarga, Inc. | Fatty alcohol drug conjugates |
AU2002303164A1 (en) | 2001-03-23 | 2002-10-08 | Protarga, Inc. | Fatty amine drug conjugates |
US20030157161A1 (en) * | 2001-05-01 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating inflammatory conditions utilizing protein or polysaccharide containing anti-microtubule agents |
CA2445763A1 (en) * | 2001-05-01 | 2002-11-07 | Angiotech Pharmaceuticals Inc. | Compositions comprising an anti-microtubule agent and a polypeptide or a polysaccharide and the use thereof for the preparation of a medicament for the treatment of inflammatory conditions |
DE10154464B4 (de) * | 2001-11-08 | 2005-10-20 | Max Delbrueck Centrum | Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol |
US20030206893A1 (en) * | 2002-05-06 | 2003-11-06 | Sohail Malik | Cell proliferating agents |
WO2004069224A2 (en) | 2003-02-03 | 2004-08-19 | Neopharm, Inc. | Stable sterile filterable liposomal encapsulated taxane and other antineoplastic drugs |
EP3345632A1 (en) * | 2005-02-18 | 2018-07-11 | Abraxis BioScience, LLC | Drugs with improved hydrophobicity for incorporation in medical devices |
JP2006248978A (ja) * | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
AU2006235538A1 (en) * | 2005-04-12 | 2006-10-19 | Wisconsin Alumni Research Foundation | Micelle composition of polymer and passenger drug |
EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
CN101878024B (zh) * | 2007-11-28 | 2014-04-09 | 塞拉特药物股份有限公司 | 改良的紫杉烷递送系统 |
WO2009126401A1 (en) * | 2008-04-10 | 2009-10-15 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
EP2480207B1 (en) | 2009-09-25 | 2016-11-09 | Wisconsin Alumni Research Foundation | Micelle encapsulation of therapeutic agents |
ES2625637T3 (es) | 2010-02-12 | 2017-07-20 | Pharmascience Inc. | Compuestos de unión al dominio BIR IAP |
TWI438009B (zh) * | 2010-02-19 | 2014-05-21 | Teikoku Pharma Usa Inc | 紫杉烷前-乳劑調配物及其製造與使用之方法 |
CN103096874A (zh) * | 2010-04-15 | 2013-05-08 | 华盛顿大学 | 前药组合物、前药纳米粒子及其使用方法 |
CN102970990A (zh) | 2010-05-03 | 2013-03-13 | 帝国制药美国公司 | 非水性紫杉烷前-乳剂制剂以及制备和使用该制剂的方法 |
PL226015B1 (pl) | 2011-03-03 | 2017-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną | Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna |
US8945627B2 (en) | 2011-05-05 | 2015-02-03 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
US20140357706A1 (en) * | 2011-10-13 | 2014-12-04 | The Uab Research Foundation | Stearate Compounds |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
CN105853403B (zh) * | 2016-05-09 | 2019-03-29 | 上海天氏利医药科技有限公司 | 一种紫杉醇棕榈酸酯脂质体及其制备方法 |
TN2019000117A1 (en) * | 2016-10-28 | 2020-10-05 | Servier Lab | Liposomal formulation for use in the treatment of cancer |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
CA2023645C (fr) * | 1989-08-23 | 2002-03-26 | Jean-Noel Denis | Procede pour la preparation enantioselective de derives de la phenylisoserine |
US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
FR2658510B1 (fr) * | 1990-02-21 | 1992-04-30 | Rhone Poulenc Sante | Nouveau derive de la beta-phenylisoserine, sa preparation et son emploi. |
FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
FR2680506B1 (fr) * | 1991-08-19 | 1994-09-02 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la beta-phenylisoserine et leur utilisation. |
AU3140093A (en) * | 1991-11-22 | 1993-06-15 | University Of Mississippi, The | Synthesis and optical resolution of the taxol side chain and related compounds |
FR2687150B1 (fr) * | 1992-02-07 | 1995-04-28 | Rhone Poulenc Rorer Sa | Procede de preparation de derives du taxane. |
US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
US5200534A (en) * | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
US5534499A (en) * | 1994-05-19 | 1996-07-09 | The University Of British Columbia | Lipophilic drug derivatives for use in liposomes |
US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
-
1995
- 1995-06-07 US US08/474,888 patent/US5580899A/en not_active Expired - Lifetime
-
1996
- 1996-01-11 CA CA002209001A patent/CA2209001C/en not_active Expired - Fee Related
- 1996-01-11 PT PT00121129T patent/PT1063234E/pt unknown
- 1996-01-11 ES ES00121129T patent/ES2154622T3/es not_active Expired - Lifetime
- 1996-01-11 DK DK00121129T patent/DK1063234T3/da active
- 1996-01-11 ES ES96903428T patent/ES2163613T3/es not_active Expired - Lifetime
- 1996-01-11 AT AT96903428T patent/ATE209196T1/de not_active IP Right Cessation
- 1996-01-11 AT AT00121129T patent/ATE238290T1/de not_active IP Right Cessation
- 1996-01-11 DE DE1063234T patent/DE1063234T1/de active Pending
- 1996-01-11 PT PT96903428T patent/PT802911E/pt unknown
- 1996-01-11 DK DK96903428T patent/DK0802911T3/da active
- 1996-01-11 DE DE69617203T patent/DE69617203T2/de not_active Expired - Fee Related
- 1996-01-11 DE DE69627722T patent/DE69627722T2/de not_active Expired - Fee Related
- 1996-01-11 EP EP96903428A patent/EP0802911B1/en not_active Expired - Lifetime
- 1996-01-11 AU AU47522/96A patent/AU691401B2/en not_active Ceased
- 1996-01-11 KR KR1019970704678A patent/KR100386002B1/ko not_active IP Right Cessation
- 1996-01-11 JP JP8521801A patent/JPH11500712A/ja not_active Ceased
- 1996-01-11 EP EP00121129A patent/EP1063234B1/en not_active Expired - Lifetime
- 1996-01-11 WO PCT/US1996/000351 patent/WO1996021658A1/en active IP Right Grant
- 1996-11-27 US US08/753,650 patent/US6118011A/en not_active Expired - Fee Related
-
1997
- 1997-12-10 US US08/988,120 patent/US5939567A/en not_active Expired - Fee Related
-
2000
- 2000-05-09 US US09/567,366 patent/US6291690B1/en not_active Expired - Fee Related
-
2001
- 2001-02-28 GR GR20010300005T patent/GR20010300005T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2154622T3 (es) | 2003-09-16 |
GR20010300005T1 (en) | 2001-02-28 |
US6291690B1 (en) | 2001-09-18 |
ES2154622T1 (es) | 2001-04-16 |
US6118011A (en) | 2000-09-12 |
PT1063234E (pt) | 2003-09-30 |
ATE238290T1 (de) | 2003-05-15 |
EP1063234A2 (en) | 2000-12-27 |
DK0802911T3 (da) | 2002-05-21 |
AU691401B2 (en) | 1998-05-14 |
US5939567A (en) | 1999-08-17 |
EP1063234A3 (en) | 2001-04-11 |
KR19980701289A (ko) | 1998-05-15 |
DE69627722T2 (de) | 2003-10-16 |
WO1996021658A1 (en) | 1996-07-18 |
CA2209001C (en) | 2007-12-18 |
DK1063234T3 (da) | 2003-06-02 |
CA2209001A1 (en) | 1996-07-18 |
DE69627722D1 (de) | 2003-05-28 |
JPH11500712A (ja) | 1999-01-19 |
DE69617203D1 (de) | 2002-01-03 |
DE69617203T2 (de) | 2002-05-08 |
EP0802911A1 (en) | 1997-10-29 |
AU4752296A (en) | 1996-07-31 |
KR100386002B1 (ko) | 2003-10-10 |
US5580899A (en) | 1996-12-03 |
DE1063234T1 (de) | 2001-05-23 |
ATE209196T1 (de) | 2001-12-15 |
EP1063234B1 (en) | 2003-04-23 |
EP0802911B1 (en) | 2001-11-21 |
PT802911E (pt) | 2002-05-31 |
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