ES2163474T3 - Derivado de espirooxatiolano-quinuclidina para el tratamiento de la xerostomia. - Google Patents
Derivado de espirooxatiolano-quinuclidina para el tratamiento de la xerostomia.Info
- Publication number
- ES2163474T3 ES2163474T3 ES95304449T ES95304449T ES2163474T3 ES 2163474 T3 ES2163474 T3 ES 2163474T3 ES 95304449 T ES95304449 T ES 95304449T ES 95304449 T ES95304449 T ES 95304449T ES 2163474 T3 ES2163474 T3 ES 2163474T3
- Authority
- ES
- Spain
- Prior art keywords
- serostomy
- salival
- cellulases
- rent
- glands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 abstract 3
- 102000005575 Cellulases Human genes 0.000 abstract 2
- 108010084185 Cellulases Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 210000004907 gland Anatomy 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000019914 Mental Fatigue Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 206010013781 dry mouth Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Abstract
SE PRESENTA UN AGENTE TERAPEUTICO PARA EL TRATAMIENTO DE LA SEROSTOMIA QUE COMPRENDE UN DERIVADO DE LA ESPIROOXATIOLANOQUINUCLIDINA O UNA SAL DE ADICION ACIDA DEL MISMO COMO INGREDIENTE ACTIVO, REPRESENTADO POR LA FORMULA (I) (EN LA QUE R{SUP, 1} Y R{SUP, 2} PUEDEN SER IGUALES O DIFERENTES Y CADA UNA REPRESENTA HIDROGENO, ALQUIL, CICLOPENTIL, CICLOHEXIL, ARIL, DIARILMETILOL, O ALQUIL QUE PUEDEN ESTAR SUSTITUIDOS POR UNO O MAS GRUPOS). EL AGENTE TERAPEUTICO ANTERIOR PUEDE ADMINISTRARSE ORALMENTE O PARENTERALMENTE Y CURA LA SEROSTOMIA. ESPECIFICAMENTE EL AGENTE PUEDE UTILIZARSE PARA MEJORAR Y/O CURAR LA BOCA SECA PROVOCADA POR VARIAS ENFERMEDADES CON CAMBIOS ORGANICOS EN LA GLANDULAS SALIVALES, LESIONES EN LAS GLANDULAS SALIVALES, ACOMPAÑADAS CON ENFERMEDADES SISTEMICAS, NECROSIS DE LAS CELULAS DE LAS GLANDULAS SALIVALES POR RADIOTERAPIA, INFECCIONES POR HIV (SIDA), HIPOFUNCION DE LA SECRECCION DE LA SALIVA, AFECCION DE DIFERENTES MEDICINAS QUE SE HAN TOMADO, Y ADEMAS FATIGA MENTAL O MALAS CONDICIONES DEBIDAS A SITUACIONES DE VIDA SOCIAL COMPLEJA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6168982A JP2852608B2 (ja) | 1994-06-27 | 1994-06-27 | 口腔乾燥症治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2163474T3 true ES2163474T3 (es) | 2002-02-01 |
Family
ID=15878165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95304449T Expired - Lifetime ES2163474T3 (es) | 1994-06-27 | 1995-06-22 | Derivado de espirooxatiolano-quinuclidina para el tratamiento de la xerostomia. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5580880A (es) |
EP (1) | EP0689836B1 (es) |
JP (1) | JP2852608B2 (es) |
KR (1) | KR100322042B1 (es) |
AT (1) | ATE205085T1 (es) |
AU (1) | AU707236B2 (es) |
CA (1) | CA2152420A1 (es) |
CY (1) | CY2290B1 (es) |
DE (1) | DE69522511T2 (es) |
DK (1) | DK0689836T3 (es) |
ES (1) | ES2163474T3 (es) |
IL (1) | IL114256A (es) |
NO (1) | NO309454B1 (es) |
TW (1) | TW401298B (es) |
ZA (1) | ZA955317B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9618341D0 (en) * | 1996-09-03 | 1996-10-16 | Scotia Holdings Plc | Method of treatment |
JP4447685B2 (ja) * | 1999-01-14 | 2010-04-07 | 第一三共株式会社 | 皮膚乾燥症治療剤 |
JP4909809B2 (ja) * | 1999-03-24 | 2012-04-04 | 生化学工業株式会社 | 人工唾液 |
WO2006013914A1 (ja) * | 2004-08-06 | 2006-02-09 | Daiichi Pharmaceutical Co., Ltd. | 口腔粘膜投与剤 |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
CA2620333A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
US20070077300A1 (en) * | 2005-09-30 | 2007-04-05 | Wynn David W | Oral compositions containing a salivation inducing agent |
EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
KR20090064418A (ko) * | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
US9161909B2 (en) * | 2007-08-24 | 2015-10-20 | Axiomedic Ltd. | Adhesive compositions for the treatment of xerostomia |
US20090053309A1 (en) * | 2007-08-24 | 2009-02-26 | Axiomedic Ltd., Gibraltar | Adhesive compositions for the treatment of xerostomia |
US9597278B2 (en) | 2008-11-13 | 2017-03-21 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
US9884082B2 (en) | 2008-11-13 | 2018-02-06 | David A. Hamlin | Compositions and methods for alleviating hyposalivation and for providing oral comfort |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8450487B2 (en) | 2010-06-08 | 2013-05-28 | Apicore, Llc | Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine |
WO2017094910A1 (ja) | 2015-12-04 | 2017-06-08 | 三栄源エフ・エフ・アイ株式会社 | 酵素処理イソクエルシトリンの利用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
US5078129A (en) * | 1987-05-01 | 1992-01-07 | Research Foundation Of State University Of New York | Device for stimulating salivation |
IL87234A (en) | 1987-08-13 | 1992-02-16 | Israel Inst Biolog Res | Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them |
US4917674A (en) * | 1988-04-04 | 1990-04-17 | Molinoff Henry C | Mouth moisturizing device |
US4906455A (en) * | 1988-04-15 | 1990-03-06 | Wm. Wrigley Jr. Company | Method for treating xerostomia employing chewing gum containing relatively insoluble, hydrophobic, food-grade organic acid |
US4983378A (en) * | 1988-11-22 | 1991-01-08 | Parnell Pharmaceuticals, Inc. | Method and composition for treating xerostomia |
US4997654A (en) * | 1989-08-14 | 1991-03-05 | Warner-Lambert Company | Method for increasing salivation for xerostomia patients |
JP3018494B2 (ja) * | 1990-11-30 | 2000-03-13 | ソニー株式会社 | 特殊効果装置 |
JP2683783B2 (ja) * | 1992-07-10 | 1997-12-03 | 雪印乳業株式会社 | シェーグレン症候群治療剤 |
-
1994
- 1994-06-27 JP JP6168982A patent/JP2852608B2/ja not_active Expired - Fee Related
-
1995
- 1995-06-06 US US08/466,373 patent/US5580880A/en not_active Expired - Lifetime
- 1995-06-10 KR KR1019950015296A patent/KR100322042B1/ko not_active IP Right Cessation
- 1995-06-21 IL IL11425695A patent/IL114256A/xx not_active IP Right Cessation
- 1995-06-21 AU AU23245/95A patent/AU707236B2/en not_active Ceased
- 1995-06-21 TW TW084106358A patent/TW401298B/zh not_active IP Right Cessation
- 1995-06-22 DE DE69522511T patent/DE69522511T2/de not_active Expired - Lifetime
- 1995-06-22 CA CA002152420A patent/CA2152420A1/en not_active Abandoned
- 1995-06-22 AT AT95304449T patent/ATE205085T1/de not_active IP Right Cessation
- 1995-06-22 DK DK95304449T patent/DK0689836T3/da active
- 1995-06-22 EP EP95304449A patent/EP0689836B1/en not_active Expired - Lifetime
- 1995-06-22 ES ES95304449T patent/ES2163474T3/es not_active Expired - Lifetime
- 1995-06-26 NO NO952561A patent/NO309454B1/no unknown
- 1995-06-27 ZA ZA955317A patent/ZA955317B/xx unknown
-
2002
- 2002-07-31 CY CY0200048A patent/CY2290B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPH0812575A (ja) | 1996-01-16 |
JP2852608B2 (ja) | 1999-02-03 |
KR960000222A (ko) | 1996-01-25 |
NO309454B1 (no) | 2001-02-05 |
IL114256A0 (en) | 1995-10-31 |
ATE205085T1 (de) | 2001-09-15 |
EP0689836A1 (en) | 1996-01-03 |
NO952561L (no) | 1995-12-28 |
DE69522511D1 (de) | 2001-10-11 |
ZA955317B (en) | 1996-02-02 |
TW401298B (en) | 2000-08-11 |
AU2324595A (en) | 1996-01-11 |
IL114256A (en) | 1999-05-09 |
DE69522511T2 (de) | 2002-05-16 |
CA2152420A1 (en) | 1995-12-28 |
AU707236B2 (en) | 1999-07-08 |
CY2290B1 (en) | 2003-07-04 |
NO952561D0 (no) | 1995-06-26 |
KR100322042B1 (ko) | 2002-11-04 |
DK0689836T3 (da) | 2002-05-06 |
US5580880A (en) | 1996-12-03 |
EP0689836B1 (en) | 2001-09-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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