ES2160597T3 - Tratamiento y profilaxis de enfermedades producidas por parasitos o bacterias. - Google Patents

Tratamiento y profilaxis de enfermedades producidas por parasitos o bacterias.

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Publication number
ES2160597T3
ES2160597T3 ES93907809T ES93907809T ES2160597T3 ES 2160597 T3 ES2160597 T3 ES 2160597T3 ES 93907809 T ES93907809 T ES 93907809T ES 93907809 T ES93907809 T ES 93907809T ES 2160597 T3 ES2160597 T3 ES 2160597T3
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Spain
Prior art keywords
parasites
prophylaxis
bacteria
treatment
diseases produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93907809T
Other languages
English (en)
Inventor
Arsalan Kharazmi
Soren Brogger Christensen
Chen Ming
Thor Grundtvig Theander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LICA Pharmaceuticals AS
Original Assignee
LICA Pharmaceuticals AS
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Filing date
Publication date
Priority claimed from DK92312A external-priority patent/DK31292D0/da
Priority claimed from DK921208A external-priority patent/DK120892D0/da
Application filed by LICA Pharmaceuticals AS filed Critical LICA Pharmaceuticals AS
Application granted granted Critical
Publication of ES2160597T3 publication Critical patent/ES2160597T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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Abstract

COMPUESTOS AROMATICOS, O PRODROGAS DE ELLOS, QUE CONTIENEN UN PUNTO ALQUILADO Y QUE SON CAPACES DE ALQUILAR EL GRUPO TIOL EN N MATICAS (ALFA)-(BETA) INSATURADAS, SON USADAS PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS O ALIMENTACION MEDICADA, AGUA DE ALIMENTOS O BEBIDAS PARA EL TRATAMIENTO O PROFILAXIS DE ENFERMEDADES CAUSADAS POR MICROORGANISMOS O PARASITOS, EN PARTICULAR PROTOZOOS TALES COMO LEISHMANIA, TRIPANOSOMA, TOXOPLASMA, PLASMODIUM, PNEUMOCYSTIS, BABESIA Y THEILERIA, PROTOZOOS INTESTINALES TALES COMO TRICHOLOMAS Y CIARDIA; COCCIDIA TALES COMO EIMERIA, ISOSPORA, CRYPTOSPORIDIUM; CAPPILARIA, MICROSPORIDIUM, SARCOCYSTIS, TRICHODINA, TRICHODINELLA, DACTHYLOGORUS, PSEUDODACTHYLOGORUS, ACANTOCEPHALUS, ICHTHYLOPHTERIUS, BOTRECEPHALUS; Y BACTERIA INTRACELULAR, EN PARTICULAR MYCOBACTERIUM, ESPECIES DE LEGIONELLA, LISTERIA Y SALMONELLA. COMPUESTOS PREFERIDOS TIENEN LA FORMULA (II): XM-PH-C(O)-CH=CH-PH-YN EN DONDE CADA GRUPO FENILO (PH) PUEDE SER MONO DESIGNAN ARH O AZ, EN DONDE A ES O,S, NH O N(C1-6 ALQUILO), RH DESIGNA HIDROCARBILO ALIFATICO, Y Z ES H O UN GRUPO DE ENMASCARAMIENTO QUE ESTA DESCOMPUESTO PARA LIBERAR AH; M ES 0, 1 O 2, Y N ES 0, 1, 2 O 3, POR LO QUE CUANDO M ES 2, ENTONCES LAS DOS X SON LO MISMO O DIFERENTE, Y CUANDO N ES 2 O 3, ENTONCES LAS DOS O TRES Y SON LO MISMO O DIFERENTE, CON LA PROVISION DE QUE N Y M NO SON AMBOS 0. COMO EJEMPLOS DE TALES COMPUESTOS, CALCONAS, P.EJ. LICOCALCONA A (OBTENIBLE P. EJ. DE MEZCLAS DE RAIZ CHINAD LICORIZADA DE ESPECIES DE GLICORRIZAS, P. EJ. G. URALENSIS O G. INFLATA) ASI COMO HIDROXILO, ALQ(EN)ILO, Y/O ANALOGOS ALQ(EN)ILOXILO DE ELLOS SON ACTIVOS IN VITRO Y/O IN VIVO CONTRA P. EJ. L. MAJOR Y P. FALCIPARUM.
ES93907809T 1992-03-06 1993-03-08 Tratamiento y profilaxis de enfermedades producidas por parasitos o bacterias. Expired - Lifetime ES2160597T3 (es)

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DK92312A DK31292D0 (da) 1992-03-06 1992-03-06 Treatment and prophylaxis of diseases caused by parasites or bacteria
DK921208A DK120892D0 (da) 1992-09-30 1992-09-30 Treatment and prophylaxis of diseases caused by parasites, fungi or bacteria

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EP0634927A1 (en) 1995-01-25
AU3887993A (en) 1993-10-05
ATE202701T1 (de) 2001-07-15
OA10098A (en) 1996-12-18
NZ251320A (en) 1999-08-30
AU682464B2 (en) 1997-10-09
US6603046B1 (en) 2003-08-05
DK0634927T3 (da) 2001-10-29
EP0634927B1 (en) 2001-07-04
DE69330403T2 (de) 2002-06-06
WO1993017671A1 (en) 1993-09-16
JPH07508504A (ja) 1995-09-21
US5985935A (en) 1999-11-16
DE69330403D1 (de) 2001-08-09
BR9306040A (pt) 1997-11-18
CA2131024A1 (en) 1993-09-16

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