ES2160190T3 - Esteres de acido sulfurico de alcoholes de azucar para la inhibicion de la migracion y proliferacion de celulas de los musculos lisos de las paredes vasculares. - Google Patents
Esteres de acido sulfurico de alcoholes de azucar para la inhibicion de la migracion y proliferacion de celulas de los musculos lisos de las paredes vasculares.Info
- Publication number
- ES2160190T3 ES2160190T3 ES96106471T ES96106471T ES2160190T3 ES 2160190 T3 ES2160190 T3 ES 2160190T3 ES 96106471 T ES96106471 T ES 96106471T ES 96106471 T ES96106471 T ES 96106471T ES 2160190 T3 ES2160190 T3 ES 2160190T3
- Authority
- ES
- Spain
- Prior art keywords
- sup
- radical
- derivative
- independently
- decreased
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
- C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
- C07C305/06—Hydrogenosulfates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
- C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
- C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
LA PRESENTE INVENCION TRATA DE NUEVOS ESTERES DE ACIDO SULFURICO Y DE COMPUESTOS SIMILARES A LOS ALCOHOLES DE AZUCAR DE FORMULA GENERAL IA Y IB EN DONDE N{SUP,1} - N{SUP,9} SON 0 O 1, INDEPENDIENTEMENTE UNO DE OTRO; Y M{SUP,1} - M{SUP,9} SON 0 O 1 INDEPENDIENTEMENTE UNO DE OTRO, CON LA CONDICION DE QUE AL MENOS UNO DE M{SUP,1}, M{SUP,2} O M{SUP,3}, AL MENOS UNO DE M{SUP,4}, M{SUP,5} O M{SUP,6}, Y SI EXISTE, AL MENOS UNO DE M{SUP,7}, M{SUP,8} O M{SUP,9} SEAN 1; Y EN DONDE X{SUP,1}- V{SUP,18} SON INDEPENDIENTEMENTE UNO DE OTRO -O-, CONR{SUP,1}-, -NR{SUP,1}CO-, -NR{SUP,1}-; R{SUP,1} ES HIDROGENO O ALQUILO DE CADENA CORTA; W ES UN RADICAL DE BENCENO O UN RADICAL DE S-TRIAZINA; Y{SUP,1} - Y{SUP,9} SON SISTEMAS CICLICOS AROMATICOS INDEPENDIENTEMENTE UNO DE OTRO; A{SUP,1} - A{SUP,3} SON, INDEPENDIENTEMENTE UNO DE OTRO, UN RADICAL DISMINUIDO EN 1 GRUPO HIDROXILO DE UN ALCOHOL DE AZUCAR, O UN DERIVADO, UN RADICAL DISMINUIDO EN 1 GRUPO CARBOXILO DE UN ACIDO CARBOXILICO DE AZUCAR, O UN DERIVADO, UN RADICAL TRIS(HIDROXIMETIL)-METILO; D ES UN RADICAL DOBLE DE UN ALCOHOL DE AZUCAR DISMINUIDO EN DOS GRUPOS HIDROXILOS, O UN DERIVADO, O UN RADICAL DOBLE DE UN ACIDO DICARBOXILICO DE AZUCAR DISMINUIDO EN DOS GRUPOS CARBOXILOS, O UN DERIVADO; Q{SUP,1} - Q{SUP,3} Y Z{SUP,1} - Z{SUP,3} SON, INDEPENDIENTEMENTE UNO DE OTRO, UN RADICAL DOBLE DE UN ALCOHOL DE AZUCAR DISMINUIDO EN 2 GRUPOS HIDROXILOS, O UN DERIVADO, O UN RADICAL DOBLE DE UN ACIDO DICARBOXILICO DE AZUCAR DISMINUIDO EN 2 GRUPOS CARBOXILOS, O UN DERIVADO, O UN RADICAL DOBLE DE DESOXIGLUCOPIRANOSA, O UN DERIVADO, ESTANDO ESTERIFICADO CON ACIDO SULFURICO AL MENOS UN GRUPO HIDROXILO DE LOS RADICALES A{SUP,1} - A{SUP,3}, D, Q{SUP,1} - Q{SUP,3} Y Z{SUP,1} - Z{SUP,3}; Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. LOS COMPUESTOS DE ACUERDO CON LA INVENCION, COMO POR EJEMPLO ESTAN INDICADOS EN EL TRATAMIENTO DE ENFERMEDADES, QUE SE CARACTERIZAN POR UNA PROLIFERACION EXCESIVA O DESTRUCTIVA DE CELULAS DE MUSCULO LISO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH131095 | 1995-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2160190T3 true ES2160190T3 (es) | 2001-11-01 |
Family
ID=4207454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96106471T Expired - Lifetime ES2160190T3 (es) | 1995-05-05 | 1996-04-24 | Esteres de acido sulfurico de alcoholes de azucar para la inhibicion de la migracion y proliferacion de celulas de los musculos lisos de las paredes vasculares. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5830920A (es) |
EP (1) | EP0741128B1 (es) |
JP (1) | JP2881752B2 (es) |
CN (1) | CN1150589A (es) |
AR (1) | AR003945A1 (es) |
AT (1) | ATE202339T1 (es) |
BR (1) | BR9602148A (es) |
CA (1) | CA2174583A1 (es) |
DE (1) | DE59607115D1 (es) |
DK (1) | DK0741128T3 (es) |
ES (1) | ES2160190T3 (es) |
GR (1) | GR3036660T3 (es) |
MX (1) | MX9601521A (es) |
PT (1) | PT741128E (es) |
TR (1) | TR199600329A2 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6864219B2 (en) | 2000-01-17 | 2005-03-08 | Bayer Aktiengesellschaft | Substituted aryl ketones |
DE60111948T2 (de) | 2000-09-07 | 2006-04-20 | TELIK, INC., Palo Alto | Benzoltricarbonsäureamide als aktivatoren des insulinrezeptors |
US7354747B1 (en) * | 2003-05-08 | 2008-04-08 | The Regents Of The University Of California | Carbohydrate derived protein resistant biomaterial |
US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
CA2751125C (en) * | 2009-01-29 | 2017-06-20 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
CN104869993B (zh) | 2012-10-25 | 2019-01-15 | 通用医疗公司 | 治疗阿尔茨海默病及相关疾病的组合疗法 |
US10058530B2 (en) | 2012-10-25 | 2018-08-28 | The General Hospital Corporation | Combination therapies for the treatment of Alzheimer's disease and related disorders |
US10525005B2 (en) | 2013-05-23 | 2020-01-07 | The General Hospital Corporation | Cromolyn compositions and methods thereof |
US10188757B2 (en) | 2013-10-22 | 2019-01-29 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
WO2015151068A1 (en) * | 2014-04-03 | 2015-10-08 | Universita' Di Pisa | Synthetic analogues of 3-iodothyronamine (t1am) and uses thereof |
WO2015150995A1 (en) | 2014-04-04 | 2015-10-08 | Pfizer Inc. | Bicyclic-fused heteroaryl or aryl compounds and their use as irak4 inhibitors |
EP3506894B1 (en) | 2016-08-31 | 2023-08-23 | The General Hospital Corporation | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases |
WO2019017995A1 (en) | 2017-07-20 | 2019-01-24 | Aztherapies, Inc. | FORMULATIONS OF CROMOLYNE SODIUM POWDER AND IBUPROFEN |
AU2019299347A1 (en) | 2018-07-02 | 2021-01-21 | Aztherapies, Inc. | Powdered formulations of cromolyn sodium and alpha-lactose |
US20220218652A1 (en) * | 2018-09-05 | 2022-07-14 | The General Hospital Corporation | Methods of treating cytokine release syndrome |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1144905A (en) * | 1965-03-25 | 1969-03-12 | Fisons Pharmaceuticals Ltd | Substituted bis-(2-carboxy-chromonyl-oxy) derivatives and preparation and pharmaceutical compositions thereof |
DE3101376A1 (de) * | 1981-01-17 | 1982-09-02 | Bayer Ag, 5090 Leverkusen | Sisomicin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
GB8612940D0 (en) * | 1986-05-28 | 1986-07-02 | Dow Chemical Co | Derivative esters |
DE3734815A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel |
DE3734853A1 (de) * | 1987-10-14 | 1989-04-27 | Luitpold Werk Chem Pharm | Bis-aldonsaeureamide und verfahren zu ihrer herstellung |
US5298616A (en) * | 1990-10-03 | 1994-03-29 | Hoffmann-La Roche Inc. | Sulfated O-polysaccharide-trehaloses |
CA2061370A1 (en) * | 1991-03-13 | 1992-09-14 | Markus Hosang | Pharmaceutical preparations |
TW308598B (es) * | 1994-01-14 | 1997-06-21 | Hoffmann La Roche |
-
1996
- 1996-04-19 CA CA002174583A patent/CA2174583A1/en not_active Abandoned
- 1996-04-19 TR TR96/00329A patent/TR199600329A2/xx unknown
- 1996-04-23 MX MX9601521A patent/MX9601521A/es unknown
- 1996-04-23 JP JP8100874A patent/JP2881752B2/ja not_active Expired - Lifetime
- 1996-04-24 EP EP96106471A patent/EP0741128B1/de not_active Expired - Lifetime
- 1996-04-24 AT AT96106471T patent/ATE202339T1/de not_active IP Right Cessation
- 1996-04-24 DE DE59607115T patent/DE59607115D1/de not_active Expired - Fee Related
- 1996-04-24 DK DK96106471T patent/DK0741128T3/da active
- 1996-04-24 ES ES96106471T patent/ES2160190T3/es not_active Expired - Lifetime
- 1996-04-24 PT PT96106471T patent/PT741128E/pt unknown
- 1996-04-26 US US08/639,986 patent/US5830920A/en not_active Expired - Fee Related
- 1996-04-30 CN CN96100231A patent/CN1150589A/zh active Pending
- 1996-05-02 AR ARP960102418A patent/AR003945A1/es unknown
- 1996-05-03 BR BR9602148-9A patent/BR9602148A/pt not_active IP Right Cessation
-
2001
- 2001-09-18 GR GR20010401520T patent/GR3036660T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TR199600329A2 (tr) | 1997-03-21 |
CA2174583A1 (en) | 1996-11-06 |
ATE202339T1 (de) | 2001-07-15 |
BR9602148A (pt) | 2005-06-21 |
PT741128E (pt) | 2001-11-30 |
CN1150589A (zh) | 1997-05-28 |
US5830920A (en) | 1998-11-03 |
EP0741128A3 (de) | 1997-03-26 |
MX9601521A (es) | 1997-02-28 |
EP0741128A2 (de) | 1996-11-06 |
DE59607115D1 (de) | 2001-07-26 |
JP2881752B2 (ja) | 1999-04-12 |
AR003945A1 (es) | 1998-09-30 |
JPH08301839A (ja) | 1996-11-19 |
GR3036660T3 (en) | 2001-12-31 |
EP0741128B1 (de) | 2001-06-20 |
DK0741128T3 (da) | 2001-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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