ES2152976T3 - Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion. - Google Patents

Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion.

Info

Publication number
ES2152976T3
ES2152976T3 ES94909837T ES94909837T ES2152976T3 ES 2152976 T3 ES2152976 T3 ES 2152976T3 ES 94909837 T ES94909837 T ES 94909837T ES 94909837 T ES94909837 T ES 94909837T ES 2152976 T3 ES2152976 T3 ES 2152976T3
Authority
ES
Spain
Prior art keywords
unmutated
amino acid
crp
precrp
subunit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94909837T
Other languages
English (en)
Inventor
Lawrence A Potempa
Hans H Liao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immtech International Inc
Original Assignee
Immtech International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immtech International Inc filed Critical Immtech International Inc
Application granted granted Critical
Publication of ES2152976T3 publication Critical patent/ES2152976T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4737—C-reactive protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCION SE REFIERE A UNA PROTEINA MUTANTE QUE TIENE LA MISMA SECUENCIA AMINOACIDA QUE UNA SUBUNIDAD DE PROTEINA CREACTIVA NO MUTADA (CRP) O PRECPR NO MUTADA, SALVO QUE AL MENOS UN AMINOACIDO DE LA SUBUNIDAD CRP NO MUTADA O PRECRP NO MUTADA HA SIDO ELIMINADO, AL MENOS UN AMINOACIDO DE LA SUBUNIDAD CRP NO MUTADA O PRECRP NO MUTADA HA SIDO SUSTITUIDO POR OTRO AMINOACIDO, AL MENOS UN AMINOACIDO HA SIDO AÑADIDO A LA SUBUNIDAD CRP NO MUTADA O PRECRP , O UNA COMBINACION DE TALES CAMBIOS HA SIDO REALIZADA. LOS AMINOACIDOS AÑADIDOS, ELIMINADO Y/O SUSTITUIDOS SON ELEGIDOS DE MANERA QUE LA PROTEINA MUTANTE ES MENOS APROPIADA PARA FORMAR AGREGADOS COVALENTEMENTE RETICULADOS QUE LA SUBUNIDAD CRP NO MUTADA O PRECRP NO MUTADA. LA PROTEINA MUTANTE TAMBIEN EXHIBE AL MENOS UNA DE LAS ACTIVIDADES BIOLOGICAS DE CRP MODIFICADA. LA INVENCION TAMBIEN PREVE MOLECULAS DE ADN QUE CODIFICAN LAS PROTEINAS MUTANTES DE LA INVENCION, VECTORES PARA EXPRESAR LAS PROTEINAS MUTANTES, CELULAS HUESPEDES QUE HAN SIDO TRANSFORMADAS DE MANERA QUE PUEDAN EXPRESAR LA PROTEINAS MUTANTES, Y UN METODO PARA PRODUCIR LAS PROTEINAS MUTANTES DE LA INVENCION QUE CONSISTE EN CULTIVAR LA CELULAS HUESPEDES TRANSFORMADAS. FINALMENTE LA INVENCION SE REFIERE A LOS METODOS Y MATERIALES PARA USAR LAS PROTEINAS MUTANTES.
ES94909837T 1993-02-26 1994-02-24 Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion. Expired - Lifetime ES2152976T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2395293A 1993-02-26 1993-02-26

Publications (1)

Publication Number Publication Date
ES2152976T3 true ES2152976T3 (es) 2001-02-16

Family

ID=21818104

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94909837T Expired - Lifetime ES2152976T3 (es) 1993-02-26 1994-02-24 Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion.

Country Status (7)

Country Link
EP (1) EP0688224B1 (es)
JP (1) JPH08507212A (es)
AT (1) ATE196649T1 (es)
AU (1) AU6252294A (es)
DE (1) DE69426018T2 (es)
ES (1) ES2152976T3 (es)
WO (1) WO1994018999A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100107263A1 (en) * 2007-01-20 2010-04-29 Boehringer Ingelheim International Gmbh & Co., Kg C-reactive protein (crp) knockout mouse
MX2016012840A (es) 2014-03-31 2017-05-09 Boehringer Ingelheim Vetmedica Gmbh Moléculas para transporte de antígeno modular mejoradas y sus usos.
US10898568B2 (en) 2015-09-30 2021-01-26 Boehringer Ingelheim Vetmedica Gmbh Modular antigen transportation molecules and uses thereof in animals
CN115785193B (zh) * 2022-11-25 2023-11-21 天津鸿宇泰生物科技有限公司 一种用于包涵体蛋白复性的复性缓冲液以及方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU633488B2 (en) * 1988-04-04 1993-02-04 Northwestern University Binding of immune complexes by modified forms of c-reactive protein

Also Published As

Publication number Publication date
EP0688224A1 (en) 1995-12-27
AU6252294A (en) 1994-09-14
EP0688224A4 (en) 1997-09-10
JPH08507212A (ja) 1996-08-06
EP0688224B1 (en) 2000-09-27
DE69426018T2 (de) 2001-02-22
WO1994018999A1 (en) 1994-09-01
DE69426018D1 (de) 2000-11-02
ATE196649T1 (de) 2000-10-15

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