ES2152024T3 - Procedimiento para desdoblar acidos quirales con 1-aminoindan-2-oles. - Google Patents

Procedimiento para desdoblar acidos quirales con 1-aminoindan-2-oles.

Info

Publication number
ES2152024T3
ES2152024T3 ES96914630T ES96914630T ES2152024T3 ES 2152024 T3 ES2152024 T3 ES 2152024T3 ES 96914630 T ES96914630 T ES 96914630T ES 96914630 T ES96914630 T ES 96914630T ES 2152024 T3 ES2152024 T3 ES 2152024T3
Authority
ES
Spain
Prior art keywords
aminoindan
disclosed
oles
procedure
chiral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914630T
Other languages
English (en)
Inventor
Eikeren Paul Van
Conville Francis X Mc
Jorge Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ES2152024T3 publication Critical patent/ES2152024T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

SE DESCUBRE UN PROCESO PARA LA RESOLUCION COMPLETA O PARCIAL DE UNA MEZCLA DE ENANTIOMEROS DE UN GENERO DE ACIDOS CARBOXILICOS QUIRALES. EL PROCESO UTILIZA UN ENANTIOMERO PURO DE 1 AMINOINDAN PARACION DE LAS SALES DIASTEREOMERICAS MEDIANTE CRISTALIZACION FRACCIONADA SEGUIDO DE LIBERACION DEL ACIDO QUIRAL DE LA SAL MEDIANTE TRATAMIENTO CON ACIDO MINERAL. SE DESCUBREN LAS SALES DIASTEREOMERICAS Y LOS SOLVATOS DE DICHAS SALES. SE DESCUBRE LA PRODUCCION DE KETOPROFENO, FLURBIPROFENO Y OTROS MEDICAMENTOS QUIRALES Y PRECURSORES DE LOS MISMOS.
ES96914630T 1995-05-18 1996-05-15 Procedimiento para desdoblar acidos quirales con 1-aminoindan-2-oles. Expired - Lifetime ES2152024T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/446,255 US5677469A (en) 1995-05-18 1995-05-18 Process for resolving chiral acids with 1-aminoindan-2-ols

Publications (1)

Publication Number Publication Date
ES2152024T3 true ES2152024T3 (es) 2001-01-16

Family

ID=23771917

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96914630T Expired - Lifetime ES2152024T3 (es) 1995-05-18 1996-05-15 Procedimiento para desdoblar acidos quirales con 1-aminoindan-2-oles.

Country Status (12)

Country Link
US (1) US5677469A (es)
EP (1) EP0828702B1 (es)
JP (1) JPH11511742A (es)
AT (1) ATE195930T1 (es)
AU (1) AU700193B2 (es)
CA (1) CA2221375A1 (es)
DE (1) DE69610089T2 (es)
DK (1) DK0828702T3 (es)
ES (1) ES2152024T3 (es)
GR (1) GR3034975T3 (es)
PT (1) PT828702E (es)
WO (1) WO1996036584A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013830A (en) * 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
EP1029846A1 (en) * 1999-02-17 2000-08-23 Sekhsaria Chemicals Ltd. Resolution of alpha-arylpropionic acids
US6479702B1 (en) 2000-09-06 2002-11-12 Daicel Chemical Industries, Ltd. 3-amino-1-indanole, method of synthesizing the same and method of optical resolution
US20030027867A1 (en) * 2001-06-29 2003-02-06 Myriad Genetics, Incorporated Use of R-NSAID compounds for anti-HIV treatment
PT1348684E (pt) * 2003-04-09 2006-05-31 Servier Lab Novo processo de sintese do acido (2s)-indolina-2-carboxilico e aplicacao a sintese do perindopril
KR101424843B1 (ko) 2007-03-29 2014-08-13 다이이찌 산쿄 가부시키가이샤 의약 조성물
EP2368870A1 (en) * 2008-12-12 2011-09-28 Daiichi Sankyo Company, Limited Process for producing optically active carboxylic acid
ES2437346T3 (es) 2008-12-17 2014-01-10 Daiichi Sankyo Company, Limited Procedimiento para la producción de derivado de diamina
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
WO2010104078A1 (ja) 2009-03-10 2010-09-16 第一三共株式会社 ジアミン誘導体の製造方法
CN102348680B (zh) 2009-03-13 2014-11-05 第一三共株式会社 用于制备光学活性二胺衍生物的方法
JPWO2010147169A1 (ja) 2009-06-18 2012-12-06 第一三共株式会社 溶出性の改善された医薬組成物
JP5692873B2 (ja) 2010-03-19 2015-04-01 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
KR101792299B1 (ko) 2010-03-19 2017-10-31 다이이찌 산쿄 가부시키가이샤 항응고제의 용출 개선 방법
JP5888705B2 (ja) * 2010-05-21 2016-03-22 ミラー ブリューイング インターナショナル、インコーポレイテッド ホップ酸及びその誘導体の製造
JP5780657B2 (ja) 2010-07-02 2015-09-16 第一三共株式会社 光学活性ジアミン誘導体の塩の製造方法
WO2013021343A1 (en) * 2011-08-05 2013-02-14 Ranbaxy Laboratories Limited Process for the optical resolution of () -3- (2 -benzyloxy- 5 - bromophenyl) - 3 - phenylpropionic
WO2013022059A1 (ja) 2011-08-10 2013-02-14 第一三共株式会社 ジアミン誘導体含有医薬組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
CA2023954C (en) * 1989-10-17 1999-05-04 Hiroyuki Nohira Process for the optical resolution of 2-(3-benzoyl) phenylpropionic acid
US5015764A (en) * 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
CA2052892A1 (en) * 1990-10-11 1992-04-12 Suresh K. Balani Inhibitors of hiv protease
DE69206306T2 (de) * 1991-04-08 1996-06-13 Sumitomo Chemical Co Optisch aktive Sekundär-Aminverbindung, Verfahren zur Herstellung einer optisch aktiven Sekundär-Aminverbindung und Verfahren zur Herstellung optisch aktiver Carbonsäure durch die Verwendung dieser Verbindung.
US5162576A (en) * 1991-04-15 1992-11-10 Ethyl Corporation Resolution of ketoprofen
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols

Also Published As

Publication number Publication date
PT828702E (pt) 2001-01-31
JPH11511742A (ja) 1999-10-12
AU700193B2 (en) 1998-12-24
DE69610089T2 (de) 2001-05-03
EP0828702A1 (en) 1998-03-18
DK0828702T3 (da) 2001-01-02
DE69610089D1 (de) 2000-10-05
CA2221375A1 (en) 1996-11-21
ATE195930T1 (de) 2000-09-15
WO1996036584A1 (en) 1996-11-21
GR3034975T3 (en) 2001-02-28
US5677469A (en) 1997-10-14
EP0828702B1 (en) 2000-08-30
AU5793296A (en) 1996-11-29

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