ATE195930T1 - Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen - Google Patents

Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen

Info

Publication number
ATE195930T1
ATE195930T1 AT96914630T AT96914630T ATE195930T1 AT E195930 T1 ATE195930 T1 AT E195930T1 AT 96914630 T AT96914630 T AT 96914630T AT 96914630 T AT96914630 T AT 96914630T AT E195930 T1 ATE195930 T1 AT E195930T1
Authority
AT
Austria
Prior art keywords
disclosed
chiral
aminoindanolen
chiral acids
separating chiral
Prior art date
Application number
AT96914630T
Other languages
English (en)
Inventor
Eikeren Paul Van
Conville Francis X Mc
Jorge Lopez
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ATE195930T1 publication Critical patent/ATE195930T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT96914630T 1995-05-18 1996-05-15 Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen ATE195930T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/446,255 US5677469A (en) 1995-05-18 1995-05-18 Process for resolving chiral acids with 1-aminoindan-2-ols
PCT/US1996/006901 WO1996036584A1 (en) 1995-05-18 1996-05-15 Process for resolving chiral acids with 1-aminoindan-2-ols

Publications (1)

Publication Number Publication Date
ATE195930T1 true ATE195930T1 (de) 2000-09-15

Family

ID=23771917

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96914630T ATE195930T1 (de) 1995-05-18 1996-05-15 Verfahren zur trennung der chiralen säuren mittels 1-aminoindan-olen

Country Status (12)

Country Link
US (1) US5677469A (de)
EP (1) EP0828702B1 (de)
JP (1) JPH11511742A (de)
AT (1) ATE195930T1 (de)
AU (1) AU700193B2 (de)
CA (1) CA2221375A1 (de)
DE (1) DE69610089T2 (de)
DK (1) DK0828702T3 (de)
ES (1) ES2152024T3 (de)
GR (1) GR3034975T3 (de)
PT (1) PT828702E (de)
WO (1) WO1996036584A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013830A (en) * 1998-03-30 2000-01-11 Sepracor Inc. Asymmetric grignard synthesis with cyclic 1,2 aminoalcohols
EP1029846A1 (de) * 1999-02-17 2000-08-23 Sekhsaria Chemicals Ltd. Racematspaltung von Alpha-Arylpropionsäuren
CN1388802A (zh) * 2000-09-06 2003-01-01 大赛璐化学工业株式会社 3－氨基－1－茚满醇、其合成方法和对映体的拆分
US20030027867A1 (en) * 2001-06-29 2003-02-06 Myriad Genetics, Incorporated Use of R-NSAID compounds for anti-HIV treatment
ES2260585T3 (es) * 2003-04-09 2006-11-01 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido (2s)-indolin-2-carboxilico y su aplicacion a la sintesis de perindopril.
CA2680039C (en) 2007-03-29 2015-05-26 Daiichi Sankyo Company, Limited Pharmaceutical composition comprising edoxaban, an anticoagulant
KR20110106840A (ko) * 2008-12-12 2011-09-29 다이이찌 산쿄 가부시키가이샤 광학 활성 카르복실산의 제조 방법
EP2371830B1 (de) 2008-12-17 2013-10-02 Daiichi Sankyo Company, Limited Verfahren zur herstellung eines diaminderivats
EP2383272A4 (de) 2009-01-13 2012-07-25 Daiichi Sankyo Co Ltd Aktiver blutgerinnungsfaktor-hemmer
JP5666424B2 (ja) 2009-03-10 2015-02-12 第一三共株式会社 ジアミン誘導体の製造方法
CN102348680B (zh) 2009-03-13 2014-11-05 第一三共株式会社 用于制备光学活性二胺衍生物的方法
RU2012101649A (ru) 2009-06-18 2013-07-27 Дайити Санкио Компани, Лимитед Фармацевтическая композиция, обладающая улучшенной растворимостью
HUE031059T2 (en) 2010-03-19 2017-06-28 Daiichi Sankyo Co Ltd Procedure for improving anticoagulant administration
WO2011115066A1 (ja) 2010-03-19 2011-09-22 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
ES2886057T3 (es) 2010-05-21 2021-12-16 Coors Brewing Co Preparación de ácidos de lúpulo y sus derivados
ES2619374T3 (es) 2010-07-02 2017-06-26 Daiichi Sankyo Company, Limited Procedimiento de preparación de sal derivada de diamina ópticamente activa
WO2013021343A1 (en) * 2011-08-05 2013-02-14 Ranbaxy Laboratories Limited Process for the optical resolution of () -3- (2 -benzyloxy- 5 - bromophenyl) - 3 - phenylpropionic
KR101940840B1 (ko) 2011-08-10 2019-01-21 다이이찌 산쿄 가부시키가이샤 디아민 유도체 함유 의약 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
US5191112A (en) * 1989-10-17 1993-03-02 Nissan Chemical Industries, Ltd. Process for optical resolution of (±)-2-(3-benzoyl)-phenylpropionic acid
US5015764A (en) * 1990-06-18 1991-05-14 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
CA2052892A1 (en) * 1990-10-11 1992-04-12 Suresh K. Balani Inhibitors of hiv protease
DE69206306T2 (de) * 1991-04-08 1996-06-13 Sumitomo Chemical Co Optisch aktive Sekundär-Aminverbindung, Verfahren zur Herstellung einer optisch aktiven Sekundär-Aminverbindung und Verfahren zur Herstellung optisch aktiver Carbonsäure durch die Verwendung dieser Verbindung.
US5162576A (en) * 1991-04-15 1992-11-10 Ethyl Corporation Resolution of ketoprofen
US5599985A (en) * 1993-09-14 1997-02-04 Sepracor, Inc. Optically pure 1-amido-2-indanols

Also Published As

Publication number Publication date
DK0828702T3 (da) 2001-01-02
ES2152024T3 (es) 2001-01-16
GR3034975T3 (en) 2001-02-28
US5677469A (en) 1997-10-14
CA2221375A1 (en) 1996-11-21
WO1996036584A1 (en) 1996-11-21
JPH11511742A (ja) 1999-10-12
PT828702E (pt) 2001-01-31
AU5793296A (en) 1996-11-29
DE69610089D1 (de) 2000-10-05
DE69610089T2 (de) 2001-05-03
EP0828702A1 (de) 1998-03-18
AU700193B2 (en) 1998-12-24
EP0828702B1 (de) 2000-08-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee