ES2148438T3 - Sintesis de benzoquinolinonas. - Google Patents

Sintesis de benzoquinolinonas.

Info

Publication number
ES2148438T3
ES2148438T3 ES95303422T ES95303422T ES2148438T3 ES 2148438 T3 ES2148438 T3 ES 2148438T3 ES 95303422 T ES95303422 T ES 95303422T ES 95303422 T ES95303422 T ES 95303422T ES 2148438 T3 ES2148438 T3 ES 2148438T3
Authority
ES
Spain
Prior art keywords
formula
compound
chem
prepare
combining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95303422T
Other languages
English (en)
Inventor
James Edmund Audia
James Joseph Droste
Perry Clark Heath
Leland Otto Weigel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2148438T3 publication Critical patent/ES2148438T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Catalysts (AREA)

Abstract

UN PROCESO PARA PREPARAR 10B-METIL-3-OXO-BENZO[F] QUINOLINONAS DE LA FORMULA EN LA QUE R ES HIDROGENO, METILTIO, CLORO, BROMO O FLUORO, Y ESTA COLOCADA EN LA 7-, 8- O 9-POSICION; COMPRENDE REACCIONAR UN COMPUESTO DE LA FORMULA CON IODURO DE METILO Y UN ETER DISOLVENTE PARA PREPARAR UN COMPUESTO DE FORMULA COMBINANDO ANHIDRIDO ACRILICO O CLORURO ACRILOILO CON LA MEZCLA DE REACCION QUE CONTIENE EL COMPUESTO DE FORMULA III PARA PREPARAR UN COMPUESTO DE LA FORMULA ENFRIANDO LA REACCION CON BICARBONATO DE SODIO, EVAPORANDO LA SOLUCION ORGANICA QUE CONTIENE EL COMPUESTO DE FORMULA IV; Y COMBINANDO EL RESIDUO QUE CONTIENE EL COMPUESTO DE FORMULA IV CON UN UN ACIDO TRIFLUOROACETICO Y UN TRIALQUILSILANO EN AUSENCIA DE UN DISOLVENTE PARA PREPARAR EL COMPUESTO DE FORMULA I.
ES95303422T 1994-05-26 1995-05-23 Sintesis de benzoquinolinonas. Expired - Lifetime ES2148438T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24958294A 1994-05-26 1994-05-26

Publications (1)

Publication Number Publication Date
ES2148438T3 true ES2148438T3 (es) 2000-10-16

Family

ID=22944128

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95303422T Expired - Lifetime ES2148438T3 (es) 1994-05-26 1995-05-23 Sintesis de benzoquinolinonas.

Country Status (14)

Country Link
EP (1) EP0684234B1 (es)
JP (1) JPH07316136A (es)
AT (1) ATE194979T1 (es)
BR (1) BR9502557A (es)
CA (1) CA2149988A1 (es)
DE (1) DE69518112T2 (es)
DK (1) DK0684234T3 (es)
ES (1) ES2148438T3 (es)
FI (1) FI952535A (es)
GR (1) GR3034634T3 (es)
HU (1) HU219450B (es)
IL (1) IL113808A (es)
PT (1) PT684234E (es)
SI (1) SI0684234T1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574160A (en) * 1994-05-26 1996-11-12 Eli Lilly And Company Syntheis of benzoquinolinones
AU754604B2 (en) * 1998-07-29 2002-11-21 Merck & Co., Inc. Tricyclic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL105168A0 (en) * 1992-04-03 1993-07-08 Lilly Co Eli Heteroannulation process

Also Published As

Publication number Publication date
FI952535A0 (fi) 1995-05-24
HUT72331A (en) 1996-04-29
GR3034634T3 (en) 2001-01-31
PT684234E (pt) 2000-12-29
JPH07316136A (ja) 1995-12-05
IL113808A (en) 1998-12-06
IL113808A0 (en) 1995-08-31
ATE194979T1 (de) 2000-08-15
HU9501509D0 (en) 1995-07-28
DE69518112D1 (de) 2000-08-31
EP0684234A1 (en) 1995-11-29
HU219450B (hu) 2001-04-28
EP0684234B1 (en) 2000-07-26
DE69518112T2 (de) 2001-03-15
BR9502557A (pt) 1996-06-04
SI0684234T1 (en) 2001-02-28
CA2149988A1 (en) 1995-11-27
FI952535A (fi) 1995-11-27
DK0684234T3 (da) 2000-09-18

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