ES2147724T3 - Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos. - Google Patents

Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos.

Info

Publication number
ES2147724T3
ES2147724T3 ES92303916T ES92303916T ES2147724T3 ES 2147724 T3 ES2147724 T3 ES 2147724T3 ES 92303916 T ES92303916 T ES 92303916T ES 92303916 T ES92303916 T ES 92303916T ES 2147724 T3 ES2147724 T3 ES 2147724T3
Authority
ES
Spain
Prior art keywords
rapamicine
immunosuppressive
inflammatory
antifungal agents
reduction products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92303916T
Other languages
English (en)
Inventor
Craig Eugene Caufield
Philip Floyd Hughes
John Henry Musser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/696,692 external-priority patent/US5102876A/en
Priority claimed from US07/741,714 external-priority patent/US5138051A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2147724T3 publication Critical patent/ES2147724T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTAN PRODUCTOS DE LA FORMULA I OBTENIDOS A PARTIR DE LA REDUCCION QUIMICA DE UNO O MAS GRUPOS DE QUETONA EN LAS POSICIONES 15, 27 Y 33 DE LA RAPAMICINA CON HIDRURO DE DIISOBUTILALUMINIO O TRIACETOXIBOROHIDRURO DE SODIO; LOS PRODUCTOS HAN DEMOSTRADO TENER PROPIEDADES FARMACOLOGICAS QUE PODRIAN HACERLOS UTILES EN EL TRATAMIENTO DEL RECHAZO DE TRASPLANTES, ENFERMEDADES AUTOINMUNES, ENFERMEDADES INFLAMATORIAS E INFECCIONES POR CANDIDA ALBICANS.
ES92303916T 1991-05-07 1992-04-30 Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos. Expired - Lifetime ES2147724T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/696,692 US5102876A (en) 1991-05-07 1991-05-07 Reduction products of rapamycin
US07/741,714 US5138051A (en) 1991-08-07 1991-08-07 Rapamycin analogs as immunosuppressants and antifungals

Publications (1)

Publication Number Publication Date
ES2147724T3 true ES2147724T3 (es) 2000-10-01

Family

ID=27105845

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92303916T Expired - Lifetime ES2147724T3 (es) 1991-05-07 1992-04-30 Productos de reduccion de la rapamicina como agentes inmunosupresores, antiinflamatorios o antifungicos.

Country Status (15)

Country Link
EP (1) EP0512754B1 (es)
JP (1) JP3108192B2 (es)
KR (1) KR100230877B1 (es)
AT (1) ATE194352T1 (es)
AU (1) AU647616B2 (es)
DE (1) DE69231215T2 (es)
DK (1) DK0512754T3 (es)
ES (1) ES2147724T3 (es)
FI (1) FI97472C (es)
GR (1) GR3034033T3 (es)
HU (1) HU217868B (es)
MX (1) MX9202031A (es)
NZ (1) NZ242616A (es)
PH (1) PH30228A (es)
PT (1) PT512754E (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5776943A (en) * 1991-05-14 1998-07-07 American Home Products Corporation Rapamycin metabolites
US5118677A (en) * 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
GB9302567D0 (en) * 1993-02-10 1993-03-24 Smithkline Beecham Plc Novel compound
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
JP3133922B2 (ja) 1995-06-09 2001-02-13 シャープ株式会社 強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
JP3480624B2 (ja) 1995-06-09 2003-12-22 シャープ株式会社 強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
US6258823B1 (en) * 1996-07-12 2001-07-10 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
GB9826882D0 (en) * 1998-12-07 1999-01-27 Novartis Ag Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives

Also Published As

Publication number Publication date
HU217868B (hu) 2000-04-28
DE69231215D1 (de) 2000-08-10
HUT62589A (en) 1993-05-28
DE69231215T2 (de) 2000-11-09
GR3034033T3 (en) 2000-11-30
EP0512754B1 (en) 2000-07-05
DK0512754T3 (da) 2000-09-18
PH30228A (en) 1997-02-05
HU9201468D0 (en) 1992-07-28
FI921893A0 (fi) 1992-04-28
AU1600892A (en) 1992-11-12
JPH05117279A (ja) 1993-05-14
KR920021553A (ko) 1992-12-18
AU647616B2 (en) 1994-03-24
FI97472B (fi) 1996-09-13
PT512754E (pt) 2000-11-30
FI97472C (fi) 1996-12-27
MX9202031A (es) 1992-11-01
NZ242616A (en) 1994-07-26
EP0512754A1 (en) 1992-11-11
JP3108192B2 (ja) 2000-11-13
ATE194352T1 (de) 2000-07-15
FI921893A (fi) 1992-11-08
KR100230877B1 (ko) 1999-11-15

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