ES2143068T3 - Brefeldina a y analogos para la transmision sinaptica mejorada. - Google Patents

Brefeldina a y analogos para la transmision sinaptica mejorada.

Info

Publication number
ES2143068T3
ES2143068T3 ES95930845T ES95930845T ES2143068T3 ES 2143068 T3 ES2143068 T3 ES 2143068T3 ES 95930845 T ES95930845 T ES 95930845T ES 95930845 T ES95930845 T ES 95930845T ES 2143068 T3 ES2143068 T3 ES 2143068T3
Authority
ES
Spain
Prior art keywords
analogs
brefeldina
synaptic transmission
improved synaptic
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95930845T
Other languages
English (en)
Inventor
Katumi Sumikawa
Ken-Ichi Ito
James L Mcgaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of ES2143068T3 publication Critical patent/ES2143068T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA BREFELDINA A Y SUS ANALOGOS Y DERIVADOS, ADMINISTRADOS PERIFERICAMENTE, SE UTILIZAN PARA ESTIMULAR EL POTENCIAL DE APRENDIZAJE E INVERTIR LAS DISFUNCIONES DE LA MEMORIA, MEDIANTE POTENCIACION INDUCIDA A LARGO PLAZO EN LOS TEJIDOS DEL HIPOCAMPO.
ES95930845T 1994-09-20 1995-08-16 Brefeldina a y analogos para la transmision sinaptica mejorada. Expired - Lifetime ES2143068T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30987194A 1994-09-20 1994-09-20

Publications (1)

Publication Number Publication Date
ES2143068T3 true ES2143068T3 (es) 2000-05-01

Family

ID=23200041

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95930845T Expired - Lifetime ES2143068T3 (es) 1994-09-20 1995-08-16 Brefeldina a y analogos para la transmision sinaptica mejorada.

Country Status (11)

Country Link
US (2) US6710073B1 (es)
EP (1) EP0782573B1 (es)
JP (1) JPH10508579A (es)
KR (1) KR970706271A (es)
AT (1) ATE190056T1 (es)
AU (1) AU703667B2 (es)
DE (1) DE69515321T2 (es)
DK (1) DK0782573T3 (es)
ES (1) ES2143068T3 (es)
NO (1) NO315929B1 (es)
WO (1) WO1996009299A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998033498A1 (en) * 1997-02-05 1998-08-06 Allelix Pharm-Eco L.P. Drugs for memory enhancement
GB0117645D0 (en) 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
WO2009019032A2 (en) * 2003-08-08 2009-02-12 Dsm Ip Assets B.V. Novel method for screening brain-active compounds
ES2795665T3 (es) 2012-09-14 2020-11-24 Abbott Lab Procedimientos para aumentar la funcionalidad cerebral utilizando 2-fucosil-lactosa
ES2572831T3 (es) 2012-09-14 2016-06-02 Abbott Laboratories Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico
CN112851622B (zh) * 2019-11-28 2023-01-10 中国海洋大学 一种大环内酯布雷菲德菌素a酯类衍生物及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5611710B2 (es) * 1972-09-13 1981-03-16
JPS57159710A (en) * 1981-03-28 1982-10-01 Koki Yagishita Antifungal germicide
DE3247379A1 (de) * 1982-12-22 1984-06-28 Basf Ag, 6700 Ludwigshafen Brefeldin-a-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
MW187A1 (en) * 1986-01-23 1987-10-14 Hoffmann La Roche Benzazecine derivatives
US5214039A (en) * 1990-02-02 1993-05-25 Taiho Pharmaceutical Co., Limited Bicyclolactam derivative for improving cerebral function
US5242932A (en) 1991-12-17 1993-09-07 The Rockefeller University Treatment of amyloidosis associated with alzheimer disease
DE4305249A1 (de) * 1993-02-20 1994-08-25 Hoechst Ag Galaktosylbrefeldin A, ein neuer Metabolit mit pharmakologischer Wirkung, ein Verfahren zu seiner Herstellung und seine Verwendung

Also Published As

Publication number Publication date
EP0782573A1 (en) 1997-07-09
ATE190056T1 (de) 2000-03-15
EP0782573B1 (en) 2000-03-01
NO971274L (no) 1997-03-19
KR970706271A (ko) 1997-11-03
NO315929B1 (no) 2003-11-17
AU3407695A (en) 1996-04-09
DE69515321D1 (de) 2000-04-06
DK0782573T3 (da) 2000-06-05
US7081474B2 (en) 2006-07-25
EP0782573A4 (en) 1998-01-14
AU703667B2 (en) 1999-04-01
DE69515321T2 (de) 2000-08-24
JPH10508579A (ja) 1998-08-25
NO971274D0 (no) 1997-03-19
WO1996009299A1 (en) 1996-03-28
US20040242553A1 (en) 2004-12-02
US6710073B1 (en) 2004-03-23

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