DE69515321T2 - Brefeldin a und analoge zur verbesserung synaptischer übertragungen - Google Patents

Brefeldin a und analoge zur verbesserung synaptischer übertragungen

Info

Publication number
DE69515321T2
DE69515321T2 DE69515321T DE69515321T DE69515321T2 DE 69515321 T2 DE69515321 T2 DE 69515321T2 DE 69515321 T DE69515321 T DE 69515321T DE 69515321 T DE69515321 T DE 69515321T DE 69515321 T2 DE69515321 T2 DE 69515321T2
Authority
DE
Germany
Prior art keywords
brefeldin
analogs
synaptic transmissions
improve synaptic
improve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69515321T
Other languages
English (en)
Other versions
DE69515321D1 (de
Inventor
Katumi Sumikawa
Ken-Ichi Ito
L Mcgaugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69515321D1 publication Critical patent/DE69515321D1/de
Publication of DE69515321T2 publication Critical patent/DE69515321T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
DE69515321T 1994-09-20 1995-08-16 Brefeldin a und analoge zur verbesserung synaptischer übertragungen Expired - Fee Related DE69515321T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30987194A 1994-09-20 1994-09-20
PCT/US1995/010454 WO1996009299A1 (en) 1994-09-20 1995-08-16 Drugs to improved synaptic transmission

Publications (2)

Publication Number Publication Date
DE69515321D1 DE69515321D1 (de) 2000-04-06
DE69515321T2 true DE69515321T2 (de) 2000-08-24

Family

ID=23200041

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69515321T Expired - Fee Related DE69515321T2 (de) 1994-09-20 1995-08-16 Brefeldin a und analoge zur verbesserung synaptischer übertragungen

Country Status (11)

Country Link
US (2) US6710073B1 (de)
EP (1) EP0782573B1 (de)
JP (1) JPH10508579A (de)
KR (1) KR970706271A (de)
AT (1) ATE190056T1 (de)
AU (1) AU703667B2 (de)
DE (1) DE69515321T2 (de)
DK (1) DK0782573T3 (de)
ES (1) ES2143068T3 (de)
NO (1) NO315929B1 (de)
WO (1) WO1996009299A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6141798A (en) * 1997-02-05 1998-08-25 Pharm-Eco Laboratories, Incorporated Drugs for memory enhancement
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
EP2173369A2 (de) * 2003-08-08 2010-04-14 DSM IP Assets B.V. Neues screening-verfahren für gehirnaktive verbindungen
ES2572831T3 (es) 2012-09-14 2016-06-02 Abbott Laboratories Composiciones nutricionales para su uso en métodos para modular los niveles de corticosterona en individuos con estrés psicológico
EP2708147B1 (de) * 2012-09-14 2020-03-11 Abbott Laboratories Verfahren zur Erhöhung der Gehirnfunktion unter Verwendung von 2-Fucosyl-Lactose
CN112851622B (zh) * 2019-11-28 2023-01-10 中国海洋大学 一种大环内酯布雷菲德菌素a酯类衍生物及应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5611710B2 (de) * 1972-09-13 1981-03-16
JPS57159710A (en) * 1981-03-28 1982-10-01 Koki Yagishita Antifungal germicide
DE3247379A1 (de) * 1982-12-22 1984-06-28 Basf Ag, 6700 Ludwigshafen Brefeldin-a-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
IL81317A (en) * 1986-01-23 1991-06-30 Hoffmann La Roche 1,2,4,5,6,7-hexahydro-4-benzazecine-3,8-dione derivatives,their preparation and pharmaceutical compositions containing them
US5214039A (en) * 1990-02-02 1993-05-25 Taiho Pharmaceutical Co., Limited Bicyclolactam derivative for improving cerebral function
US5242932A (en) 1991-12-17 1993-09-07 The Rockefeller University Treatment of amyloidosis associated with alzheimer disease
DE4305249A1 (de) * 1993-02-20 1994-08-25 Hoechst Ag Galaktosylbrefeldin A, ein neuer Metabolit mit pharmakologischer Wirkung, ein Verfahren zu seiner Herstellung und seine Verwendung

Also Published As

Publication number Publication date
US20040242553A1 (en) 2004-12-02
WO1996009299A1 (en) 1996-03-28
EP0782573A1 (de) 1997-07-09
AU703667B2 (en) 1999-04-01
NO971274L (no) 1997-03-19
AU3407695A (en) 1996-04-09
JPH10508579A (ja) 1998-08-25
DK0782573T3 (da) 2000-06-05
ES2143068T3 (es) 2000-05-01
EP0782573A4 (de) 1998-01-14
EP0782573B1 (de) 2000-03-01
KR970706271A (ko) 1997-11-03
ATE190056T1 (de) 2000-03-15
NO971274D0 (no) 1997-03-19
US6710073B1 (en) 2004-03-23
NO315929B1 (no) 2003-11-17
DE69515321D1 (de) 2000-04-06
US7081474B2 (en) 2006-07-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee