ES2136011B1 - Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados. - Google Patents
Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados.Info
- Publication number
- ES2136011B1 ES2136011B1 ES009700637A ES9700637A ES2136011B1 ES 2136011 B1 ES2136011 B1 ES 2136011B1 ES 009700637 A ES009700637 A ES 009700637A ES 9700637 A ES9700637 A ES 9700637A ES 2136011 B1 ES2136011 B1 ES 2136011B1
- Authority
- ES
- Spain
- Prior art keywords
- synthesis
- procedure
- preparation
- contrast media
- useful intermediate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Abstract
Procedimiento para la preparación de un intermedio útil en la síntesis de medios de contraste yodados.Se describe un procedimiento para la preparación de (S) - n,n"'' - bis [2 - hidroxi - 1 - (hidroximetil) etil] - 5 - (2 - acetoxi - propionilamino) - 2, 4, 6 - triyodo - isoftalamida, un intermedio útil para la síntesis de iopamidol, mediante reacción entre dicloruro de L - 5 - (2 - acetoxi - propionilamino) - 2, 4, 6 - triyodo - isoftaloilo y 2 - amino - 1,3 - propandiol en N-metilpirrolidona y en presencia de unabase.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI000621A IT1283319B1 (it) | 1996-03-29 | 1996-03-29 | Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2136011A1 ES2136011A1 (es) | 1999-11-01 |
ES2136011B1 true ES2136011B1 (es) | 2000-07-01 |
Family
ID=11373817
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009700637A Expired - Fee Related ES2136011B1 (es) | 1996-03-29 | 1997-03-25 | Procedimiento para la preparacion de un intermedio util en la sintesis de medios de contraste yodados. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5817861A (es) |
JP (1) | JP4035198B2 (es) |
BE (1) | BE1010961A3 (es) |
CA (1) | CA2201012C (es) |
CH (1) | CH692044A5 (es) |
CZ (1) | CZ96097A3 (es) |
DE (1) | DE19713456B4 (es) |
DK (1) | DK32297A (es) |
ES (1) | ES2136011B1 (es) |
FI (1) | FI971318A (es) |
FR (1) | FR2746796B1 (es) |
GB (1) | GB2311524B (es) |
HU (1) | HU225647B1 (es) |
IE (1) | IE970214A1 (es) |
IL (1) | IL120483A (es) |
IT (1) | IT1283319B1 (es) |
NL (1) | NL1005650C2 (es) |
NO (1) | NO322508B1 (es) |
PT (1) | PT101982B (es) |
SE (1) | SE9701145L (es) |
ZA (1) | ZA972627B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6262303B1 (en) | 1998-05-08 | 2001-07-17 | Dibra S.P.A. | Process for the preparation of S-N,N′-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)-amino]-2,4,6-triiodo-1,3-benzenedicarboxamide |
IT1299202B1 (it) * | 1998-05-08 | 2000-02-29 | Dibra Spa | Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo |
IT1302200B1 (it) * | 1998-09-11 | 2000-07-31 | Dibra Spa | PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1- |
KR20000075115A (ko) * | 1999-05-28 | 2000-12-15 | 강재헌 | 불순물 c가 제거된 이오파미돌의 신규 제조방법 |
BRPI0921464B8 (pt) * | 2008-11-18 | 2021-05-25 | Bracco Imaging Spa | processo para preparação de agente de contraste iodado |
CN105272899B (zh) * | 2015-11-17 | 2017-09-22 | 浙江海洲制药有限公司 | 一种化合物及其用于合成碘帕醇杂质d、杂质f、杂质g和杂质j的方法 |
WO2019160037A1 (ja) * | 2018-02-14 | 2019-08-22 | 国立大学法人 東京大学 | 酸ハロゲン化物による化合物の製造方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH608189A5 (es) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
CH616403A5 (en) * | 1975-10-29 | 1980-03-31 | Bracco Ind Chimica Spa | Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water. |
FR2656865B1 (fr) * | 1990-01-05 | 1993-03-26 | Guerbet Sa | Compose non ionique iode, son procede de preparation et produit de contraste le contenant. |
ES2017277A6 (es) * | 1989-09-20 | 1991-01-16 | Juste Sa | Un procedimiento para la preparacion de nuevos agentes iodados no ionicos de contraste. |
IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
IT1256163B (it) * | 1992-10-27 | 1995-11-29 | Zambon Spa | Processo per la preparazione di un intermedio della sintesi organica |
DE4320499A1 (de) * | 1993-05-14 | 1994-11-17 | Bayer Ag | Verfahren zur Herstellung von 2-Oximinoessigsäurederivaten |
IT1274027B (it) * | 1994-03-03 | 1997-07-14 | Zambon Spa | Processo per la preparazione e purificazione di mezzi di contrasto iodurati |
-
1996
- 1996-03-29 IT IT96MI000621A patent/IT1283319B1/it active IP Right Grant
-
1997
- 1997-03-18 IL IL12048397A patent/IL120483A/xx not_active IP Right Cessation
- 1997-03-20 IE IE970214A patent/IE970214A1/en not_active IP Right Cessation
- 1997-03-21 US US08/822,463 patent/US5817861A/en not_active Expired - Lifetime
- 1997-03-21 DK DK032297A patent/DK32297A/da not_active Application Discontinuation
- 1997-03-21 PT PT101982A patent/PT101982B/pt active IP Right Grant
- 1997-03-21 FR FR9703463A patent/FR2746796B1/fr not_active Expired - Lifetime
- 1997-03-24 GB GB9706095A patent/GB2311524B/en not_active Expired - Lifetime
- 1997-03-25 ES ES009700637A patent/ES2136011B1/es not_active Expired - Fee Related
- 1997-03-25 NO NO19971426A patent/NO322508B1/no not_active IP Right Cessation
- 1997-03-25 CA CA002201012A patent/CA2201012C/en not_active Expired - Lifetime
- 1997-03-25 CH CH00721/97A patent/CH692044A5/it not_active IP Right Cessation
- 1997-03-26 ZA ZA9702627A patent/ZA972627B/xx unknown
- 1997-03-26 NL NL1005650A patent/NL1005650C2/nl not_active IP Right Cessation
- 1997-03-27 FI FI971318A patent/FI971318A/fi unknown
- 1997-03-27 SE SE9701145A patent/SE9701145L/ not_active Application Discontinuation
- 1997-03-27 HU HU9700667A patent/HU225647B1/hu unknown
- 1997-03-28 BE BE9700288A patent/BE1010961A3/fr not_active IP Right Cessation
- 1997-03-28 CZ CZ97960A patent/CZ96097A3/cs unknown
- 1997-03-28 JP JP07734497A patent/JP4035198B2/ja not_active Expired - Lifetime
- 1997-04-01 DE DE19713456A patent/DE19713456B4/de not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC2A | Transfer of patent | ||
EC2A | Search report published |
Date of ref document: 19991101 Kind code of ref document: A1 Effective date: 19991101 |
|
FD2A | Announcement of lapse in spain |
Effective date: 20170630 |