ME00606B - Postupak za pripremanje n,n’-bis[2,3-dihidroksipropil]–5- [(hidroksiacetil)metilamino]-2,4,6-trijodo-1,3-benzendikarboksamida - Google Patents

Postupak za pripremanje n,n’-bis[2,3-dihidroksipropil]–5- [(hidroksiacetil)metilamino]-2,4,6-trijodo-1,3-benzendikarboksamida

Info

Publication number
ME00606B
ME00606B MEP-2009-88A MEP200988A ME00606B ME 00606 B ME00606 B ME 00606B ME P200988 A MEP200988 A ME P200988A ME 00606 B ME00606 B ME 00606B
Authority
ME
Montenegro
Prior art keywords
hydroxyacetyl
dihydroxypropyl
methylamino
bis
preparation
Prior art date
Application number
MEP-2009-88A
Other languages
English (en)
French (fr)
Inventor
Laura Alessandroni
Patrizia Ambrosetti
Maria Argese
Renato Geremia
Enrico Moretti
Vittorio Valle
Giorgio Ripa
Marcella Murru
Original Assignee
Bracco Int B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int B V filed Critical Bracco Int B V
Publication of ME00606B publication Critical patent/ME00606B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Novi postupak pripremanja N,N’-bis [ 2,3-dihidroksipropil ] -5- [ (hidroksiacetil)metilamino ] -2,4,6-trijodo-1,3-benzendikarboksamidaformule (I) opšte poznatog kao Iomeprol, novog ne-jonskog kontrasnog agensakoji pokazuje vrlo dobru sigurnost i efektivnu kontrastnost.
MEP-2009-88A 1998-11-27 1999-11-25 Postupak za pripremanje n,n’-bis[2,3-dihidroksipropil]–5- [(hidroksiacetil)metilamino]-2,4,6-trijodo-1,3-benzendikarboksamida ME00606B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002574A IT1303797B1 (it) 1998-11-27 1998-11-27 Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.
PCT/EP1999/009118 WO2000032561A1 (en) 1998-11-27 1999-11-25 A process for the preparation of n,n'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide

Publications (1)

Publication Number Publication Date
ME00606B true ME00606B (me) 2011-12-20

Family

ID=11381150

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-88/09A MEP8809A (en) 1998-11-27 1999-11-25 A process for the preparation of n,n'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide
MEP-2009-88A ME00606B (me) 1998-11-27 1999-11-25 Postupak za pripremanje n,n’-bis[2,3-dihidroksipropil]–5- [(hidroksiacetil)metilamino]-2,4,6-trijodo-1,3-benzendikarboksamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MEP-88/09A MEP8809A (en) 1998-11-27 1999-11-25 A process for the preparation of n,n'-bis[2, 3-dihydroxypropyl] -5-[ (hydroxyacetyl) methylamino]-2, 4,6-triiodo-1, 3-benzenedi carboxamide

Country Status (24)

Country Link
US (1) US6420603B1 (me)
EP (1) EP1133466B1 (me)
JP (1) JP4439123B2 (me)
KR (1) KR100630400B1 (me)
CN (1) CN1163474C (me)
AT (1) ATE247630T1 (me)
AU (1) AU753601B2 (me)
BR (1) BR9915608B1 (me)
CA (1) CA2351717C (me)
CZ (1) CZ296096B6 (me)
DE (1) DE69910609T2 (me)
EA (1) EA003253B1 (me)
ES (1) ES2205949T3 (me)
HK (1) HK1040988B (me)
HR (1) HRP20010393B1 (me)
HU (1) HU229092B1 (me)
IL (1) IL143150A0 (me)
IT (1) IT1303797B1 (me)
ME (2) MEP8809A (me)
NO (1) NO327037B1 (me)
RS (1) RS50038B (me)
SK (1) SK285050B6 (me)
TR (1) TR200101439T2 (me)
WO (1) WO2000032561A1 (me)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2243767A1 (en) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
DK2451994T3 (da) * 2009-07-07 2014-01-20 Bracco Imaging Spa Fremgangsmåde til fremstilling af et ioderende middel
EP2277846A1 (en) * 2009-07-21 2011-01-26 GE Healthcare AS Obtaining free iodine in preparation of aqueous iodine chloride by adding potassium iodide
EP2394984A1 (en) * 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives
IT1403988B1 (it) * 2010-07-15 2013-11-08 Bracco Imaging Spa Processo per la preparazione di agenti di contrasto.
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
KR101833334B1 (ko) * 2016-04-29 2018-02-28 (주)유케이케미팜 신규 중간체 화합물 및 이를 이용한 이오메프롤의 제조방법
KR102128423B1 (ko) 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
WO2023046815A1 (en) 2021-09-24 2023-03-30 Bracco Imaging Spa Electrochemical iodination of n,n'-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide
WO2023209165A1 (en) 2022-04-29 2023-11-02 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodophenol derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196363B (it) * 1984-12-10 1988-11-16 Bracco Ind Chimica Spa Derivati dell'acido 5-alcossi-2,4,6-triiodo- o -tribromo-isoftalico,metodo per la loro preparazione e relativi mezzi di contrasto radiologici
IE63232B1 (en) * 1987-05-22 1995-04-05 Bracco Int Bv A process for the preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process

Also Published As

Publication number Publication date
HUP0104507A2 (hu) 2002-04-29
SK285050B6 (sk) 2006-05-04
EP1133466A1 (en) 2001-09-19
HUP0104507A3 (en) 2004-07-28
HK1040988A1 (en) 2002-06-28
ES2205949T3 (es) 2004-05-01
BR9915608A (pt) 2001-08-14
ATE247630T1 (de) 2003-09-15
IL143150A0 (en) 2002-04-21
AU1386200A (en) 2000-06-19
DE69910609T2 (de) 2004-03-18
EA200100462A1 (ru) 2001-12-24
US6420603B1 (en) 2002-07-16
SK7052001A3 (en) 2001-12-03
CZ296096B6 (cs) 2006-01-11
AU753601B2 (en) 2002-10-24
DE69910609D1 (de) 2003-09-25
ITMI982574A1 (it) 2000-05-27
JP2002531432A (ja) 2002-09-24
EA003253B1 (ru) 2003-02-27
KR20010101053A (ko) 2001-11-14
BR9915608B1 (pt) 2010-11-16
MEP8809A (en) 2011-12-20
CA2351717A1 (en) 2000-06-08
KR100630400B1 (ko) 2006-10-02
CA2351717C (en) 2010-10-05
IT1303797B1 (it) 2001-02-23
WO2000032561A1 (en) 2000-06-08
NO20012547L (no) 2001-07-25
JP4439123B2 (ja) 2010-03-24
TR200101439T2 (tr) 2001-10-22
HRP20010393B1 (en) 2004-04-30
NO327037B1 (no) 2009-04-06
HU229092B1 (en) 2013-07-29
HK1040988B (zh) 2005-04-29
CN1163474C (zh) 2004-08-25
YU37101A (sh) 2003-04-30
CN1328539A (zh) 2001-12-26
RS50038B (sr) 2008-11-28
HRP20010393A2 (en) 2002-06-30
CZ20011833A3 (cs) 2001-10-17
NO20012547D0 (no) 2001-05-23
EP1133466B1 (en) 2003-08-20

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