ES2132671T3 - Peptidos antagonistas de la neurotensina. - Google Patents

Peptidos antagonistas de la neurotensina.

Info

Publication number
ES2132671T3
ES2132671T3 ES95920949T ES95920949T ES2132671T3 ES 2132671 T3 ES2132671 T3 ES 2132671T3 ES 95920949 T ES95920949 T ES 95920949T ES 95920949 T ES95920949 T ES 95920949T ES 2132671 T3 ES2132671 T3 ES 2132671T3
Authority
ES
Spain
Prior art keywords
pct
compound
radical
date nov
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95920949T
Other languages
English (en)
Inventor
Francois-Frederic Clerc
Marie-Christine Dubroeucq
Gerard Helynck
Jean Leboul
Jean-Paul Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2132671T3 publication Critical patent/ES2132671T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C27/00—Processes involving the simultaneous production of more than one class of oxygen-containing compounds
    • C07C27/20—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction
    • C07C27/22—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction with the use of catalysts which are specific for this process
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/083—Neurotensin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE R REPRESENTA UN RADICAL HIDROXI, ALQUILOXI, FENILALQUILOXI O -NH-CH{SUB,2}-COOH, R{SUB,1} REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ADAMANTILACETILO, ADAMANTILCARBONILO, NORBONILACTILO, NORBONILFENOXICARBONILO, BENZOILO, NICOTINOILO, 4-FENILBENZOILO, 4-TERT-BUTILBENZOILO, 2,PIRROLIDINACARBONILO O UN GRUPO PROTECTOR DE UNA FUNCION AMINA, R{SUB,2} REPRESENTA UN RESIDUO ARG O LYS, R{SUB,3} REPRESENTA UN RESIDUO ARG O LYS, R{SUB,4} REPRESENTA UN RESIDUO PRO, M,. N Y P, IDENTICOS O DIFERENTES REPRESENTAN UN NUMERO IGUAL A = O 1, ENTENDIENDOSE QUE CUANDO R{SUB,1} ES UN ATOMO DE HIDROGENO, LA SUMA M*N*P ES AL MENOS IGUAL A 1, R{SUB,5} Y R{SUB,6} SON IDENTICOS Y REPRESENTAN UN RADICAL HIDROXI O METOXI Y R{SUB,7} REPRESENTA UN ATOMO DE HIDROGENO, DE CLORO, DE BROMO O DE YODO O UN RADICAL NITRO, LOS EQUIVALENTES DE LOS COMPUESTOS DE FORMULA (I) EN LOS QUE UNO O VARIOS ENLACES PEPTIDICOS (CO-NH) ENTRE DOS RESIDUOS DE AMINOACIDO ESTAN SUSTITUIDOS POR ENLACES CH{SUB,2}-NH Y/O EL ENLACE PEPTIDICO (CO-NH) ENTRE LOS RESIDUOS DE AMINOACIDO R{SUB,2} Y R{SUB,3} ES SUSTITUIDO POR UN ENLACE CH=CH, SUS SALES, SU PREPARACION Y LOS MEDICAMENTOS QUE LOS CONTIENEN.
ES95920949T 1994-05-20 1995-05-17 Peptidos antagonistas de la neurotensina. Expired - Lifetime ES2132671T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9406167A FR2720066B1 (fr) 1994-05-20 1994-05-20 Peptides antagonistes de la neurotensine.

Publications (1)

Publication Number Publication Date
ES2132671T3 true ES2132671T3 (es) 1999-08-16

Family

ID=9463378

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95920949T Expired - Lifetime ES2132671T3 (es) 1994-05-20 1995-05-17 Peptidos antagonistas de la neurotensina.

Country Status (13)

Country Link
US (1) US5840682A (es)
EP (1) EP0759934B1 (es)
JP (1) JPH10500424A (es)
AT (1) ATE178905T1 (es)
AU (1) AU2619595A (es)
DE (1) DE69509084T2 (es)
DK (1) DK0759934T3 (es)
ES (1) ES2132671T3 (es)
FR (1) FR2720066B1 (es)
GR (1) GR3029950T3 (es)
IL (1) IL113767A (es)
WO (1) WO1995032218A1 (es)
ZA (1) ZA954026B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0001316A3 (en) * 1997-02-03 2001-10-29 Mallinckrodt Inc Method for the detection and localization of malignant human tumours
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
ES2538002T3 (es) 2009-01-07 2015-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Métodos para el tratamiento, la evaluación pronóstica y la detección de cáncer de mama

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439359A (en) * 1982-07-02 1984-03-27 Merck & Co., Inc. Cyclic octapeptide analogs of neurotensin
US5162497A (en) * 1987-09-24 1992-11-10 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
US5430047A (en) * 1994-04-07 1995-07-04 Warner-Lambert Company Neurotensin antagonists
FR2720065B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Métabolite de fermentation d'actinomycètes A 9738 intermédiaire pour la préparation d'antagonistes de la neurotensine.

Also Published As

Publication number Publication date
DE69509084T2 (de) 1999-08-12
WO1995032218A1 (fr) 1995-11-30
FR2720066A1 (fr) 1995-11-24
FR2720066B1 (fr) 1996-06-28
AU2619595A (en) 1995-12-18
JPH10500424A (ja) 1998-01-13
ZA954026B (en) 1996-03-06
GR3029950T3 (en) 1999-07-30
US5840682A (en) 1998-11-24
EP0759934A1 (fr) 1997-03-05
DK0759934T3 (da) 1999-08-02
EP0759934B1 (fr) 1999-04-14
IL113767A (en) 1999-04-11
ATE178905T1 (de) 1999-04-15
IL113767A0 (en) 1995-08-31
DE69509084D1 (de) 1999-05-20

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