DE69509084D1 - Peptidische neurotensin-antagonisten - Google Patents

Peptidische neurotensin-antagonisten

Info

Publication number
DE69509084D1
DE69509084D1 DE69509084T DE69509084T DE69509084D1 DE 69509084 D1 DE69509084 D1 DE 69509084D1 DE 69509084 T DE69509084 T DE 69509084T DE 69509084 T DE69509084 T DE 69509084T DE 69509084 D1 DE69509084 D1 DE 69509084D1
Authority
DE
Germany
Prior art keywords
pct
compound
radical
date nov
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69509084T
Other languages
English (en)
Other versions
DE69509084T2 (de
Inventor
Francois-Frederic Clerc
Marie-Christine Dubroeucq
Gerard Helynck
Jean Leboul
Jean-Paul Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of DE69509084D1 publication Critical patent/DE69509084D1/de
Publication of DE69509084T2 publication Critical patent/DE69509084T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C27/00—Processes involving the simultaneous production of more than one class of oxygen-containing compounds
    • C07C27/20—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction
    • C07C27/22—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction with the use of catalysts which are specific for this process
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/083—Neurotensin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/18—Kallidins; Bradykinins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69509084T 1994-05-20 1995-05-17 Peptidische neurotensin-antagonisten Expired - Fee Related DE69509084T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9406167A FR2720066B1 (fr) 1994-05-20 1994-05-20 Peptides antagonistes de la neurotensine.
PCT/FR1995/000643 WO1995032218A1 (fr) 1994-05-20 1995-05-17 Peptides antagonistes de la neurotensine

Publications (2)

Publication Number Publication Date
DE69509084D1 true DE69509084D1 (de) 1999-05-20
DE69509084T2 DE69509084T2 (de) 1999-08-12

Family

ID=9463378

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69509084T Expired - Fee Related DE69509084T2 (de) 1994-05-20 1995-05-17 Peptidische neurotensin-antagonisten

Country Status (13)

Country Link
US (1) US5840682A (de)
EP (1) EP0759934B1 (de)
JP (1) JPH10500424A (de)
AT (1) ATE178905T1 (de)
AU (1) AU2619595A (de)
DE (1) DE69509084T2 (de)
DK (1) DK0759934T3 (de)
ES (1) ES2132671T3 (de)
FR (1) FR2720066B1 (de)
GR (1) GR3029950T3 (de)
IL (1) IL113767A (de)
WO (1) WO1995032218A1 (de)
ZA (1) ZA954026B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0968001B1 (de) * 1997-02-03 2003-11-05 Mallinckrodt Inc. Verfahren zur detektion und lokalisation maligner meschlicher tumore des pankreas
DE10226921A1 (de) * 2002-06-17 2003-12-24 Bayer Ag Antibakterielle Amid-Makrozyklen
DE10358824A1 (de) * 2003-12-16 2005-07-21 Bayer Healthcare Ag Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014245A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen V
DE102005014247A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Makrozyklen VI
DE102005032781A1 (de) * 2005-07-14 2007-01-18 Aicuris Gmbh & Co. Kg Antibakterielle Amid-Markozyklen VII
EP2374003B1 (de) 2009-01-07 2015-03-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur behandlung, prognosebeurteilung und erkennung von brustkrebs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439359A (en) * 1982-07-02 1984-03-27 Merck & Co., Inc. Cyclic octapeptide analogs of neurotensin
US5162497A (en) * 1987-09-24 1992-11-10 The Administrators Of The Tulane Educational Fund Bradykinin analogs with non-peptide bond
US5430047A (en) * 1994-04-07 1995-07-04 Warner-Lambert Company Neurotensin antagonists
FR2720065B1 (fr) * 1994-05-20 1996-06-28 Rhone Poulenc Rorer Sa Métabolite de fermentation d'actinomycètes A 9738 intermédiaire pour la préparation d'antagonistes de la neurotensine.

Also Published As

Publication number Publication date
JPH10500424A (ja) 1998-01-13
DK0759934T3 (da) 1999-08-02
EP0759934A1 (de) 1997-03-05
US5840682A (en) 1998-11-24
ES2132671T3 (es) 1999-08-16
FR2720066A1 (fr) 1995-11-24
AU2619595A (en) 1995-12-18
FR2720066B1 (fr) 1996-06-28
GR3029950T3 (en) 1999-07-30
IL113767A0 (en) 1995-08-31
WO1995032218A1 (fr) 1995-11-30
ATE178905T1 (de) 1999-04-15
DE69509084T2 (de) 1999-08-12
EP0759934B1 (de) 1999-04-14
ZA954026B (en) 1996-03-06
IL113767A (en) 1999-04-11

Similar Documents

Publication Publication Date Title
SE9604341D0 (sv) Hepta-peptide oxytocin analogue
FR2364948A1 (fr) Systemes adhesifs comprenant un polyamide contenant une bisamino piperazine
JP2012512903A5 (de)
HUP0204272A2 (hu) Kortikotropin-felszabadító faktor antagonisták, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ATE116638T1 (de) N-substituierte lactame als cholecystokinin- antagonisten.
ATE64396T1 (de) Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE184022T1 (de) Neuropeptide y antagoniste
RS51852B (sr) Modifikovani peptidi kao terapeutski agensi
DK1326634T3 (da) Vaccinepræparat der omfatter et antigen og et peptid med adjuvansegenskaber
HUP0102579A2 (hu) Antiangiogén hatású peptid gyógyszervegyületek, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
DE69509084D1 (de) Peptidische neurotensin-antagonisten
ES8707547A1 (es) Procedimiento para preparar un oligopeptidil-argininol u-homoargininol o derivado de estos
DE60335101D1 (de) Antimikrobielles polypeptid und nutzung davon
DE69637535D1 (de) Mittel auf basis radiomarkierter peptide zur ortsspezifischen verabreichung
ATE254121T1 (de) Heterocyclische verbindungen als bradykinin antagonisten
MX9801987A (es) Nuevos derivados de aminoacido, su obtencion y su uso.
WO2002066500A2 (de) ANTAGONISTEN FÜR Α4β7-INTEGRIN
ES2141827T3 (es) Peptidos que tienen actividad antagonista de endotelina, su preparacion y composiciones farmaceuticas de los mismos.
DE68923592T2 (de) HIV Protease-Hemmer.
DE60109412D1 (en) Therapeutische peptide
ES8605769A1 (es) Un procedimiento para la preparacion de un peptido
DE69119409D1 (de) Vasoaktive derivate des vasotocins
DE3571990D1 (en) Reduced peptides, inhibitors of gastric secretion, preparation process and pharmaceutical compositions containing them
JPWO2019164987A5 (de)
DE69715910D1 (de) Pharmazeutische zusammensetzung enthaltend peptide für die inhibierung der immunoglobulin-rezeptor interaktion

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee