ES2121389T3 - Derivados de alquildiamina sustituidos y su uso como antagonistas de taquiquinina. - Google Patents
Derivados de alquildiamina sustituidos y su uso como antagonistas de taquiquinina.Info
- Publication number
- ES2121389T3 ES2121389T3 ES95920539T ES95920539T ES2121389T3 ES 2121389 T3 ES2121389 T3 ES 2121389T3 ES 95920539 T ES95920539 T ES 95920539T ES 95920539 T ES95920539 T ES 95920539T ES 2121389 T3 ES2121389 T3 ES 2121389T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- antagonists
- taquiquinine
- useful
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the nitrogen atom of at least one of the carboxamide groups further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/262,209 US5597845A (en) | 1994-06-20 | 1994-06-20 | Substituted alkyldiamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2121389T3 true ES2121389T3 (es) | 1998-11-16 |
Family
ID=22996631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95920539T Expired - Lifetime ES2121389T3 (es) | 1994-06-20 | 1995-05-19 | Derivados de alquildiamina sustituidos y su uso como antagonistas de taquiquinina. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5597845A (enExample) |
| EP (1) | EP0767783B1 (enExample) |
| JP (1) | JP3920916B2 (enExample) |
| KR (1) | KR100371981B1 (enExample) |
| CN (1) | CN1083429C (enExample) |
| AT (1) | ATE169905T1 (enExample) |
| AU (1) | AU691619B2 (enExample) |
| CA (1) | CA2193348C (enExample) |
| DE (1) | DE69504198T2 (enExample) |
| DK (1) | DK0767783T3 (enExample) |
| ES (1) | ES2121389T3 (enExample) |
| FI (1) | FI115135B (enExample) |
| HU (1) | HUT75965A (enExample) |
| IL (1) | IL114185A (enExample) |
| MX (1) | MX9606654A (enExample) |
| NO (1) | NO307458B1 (enExample) |
| NZ (1) | NZ287291A (enExample) |
| TW (1) | TW442451B (enExample) |
| WO (1) | WO1995035279A1 (enExample) |
| ZA (1) | ZA954947B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW541295B (en) * | 1999-01-05 | 2003-07-11 | Nippon Zoki Pharmaceutical Co | A novel substituted alkylteraamine derivative for use as tachykinin antagonist |
| US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
| US7361678B2 (en) | 2002-03-05 | 2008-04-22 | Transtech Pharma, Inc. | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents |
| WO2002070473A2 (en) | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
| EP1387680A4 (en) | 2001-03-05 | 2010-01-13 | Transtech Pharma Inc | AGENTS TH RAPEUTICES D RIV S BENZIMIDAZOLE BASE |
| US20090263370A1 (en) * | 2006-11-30 | 2009-10-22 | Guoliang Tao | Methods for treating tachykinin-mediated diseases with cholinesterase |
| JP5805646B2 (ja) | 2009-09-30 | 2015-11-04 | ブイティーブイ・セラピューティクス・エルエルシー | アルツハイマー病の治療のための置換イミダゾール誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5164372A (en) * | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
| JPH06509087A (ja) * | 1991-07-05 | 1994-10-13 | メルク シヤープ エンド ドーム リミテツド | 芳香族化合物、それらを含む医薬組成物、及び治療におけるそれらの使用 |
| EP0655055B1 (en) * | 1992-08-13 | 2000-11-29 | Warner-Lambert Company | Tachykinin antagonists |
-
1994
- 1994-06-20 US US08/262,209 patent/US5597845A/en not_active Expired - Fee Related
-
1995
- 1995-05-19 AU AU25961/95A patent/AU691619B2/en not_active Ceased
- 1995-05-19 AT AT95920539T patent/ATE169905T1/de not_active IP Right Cessation
- 1995-05-19 CN CN95193680A patent/CN1083429C/zh not_active Expired - Fee Related
- 1995-05-19 HU HU9603540A patent/HUT75965A/hu not_active Application Discontinuation
- 1995-05-19 MX MX9606654A patent/MX9606654A/es not_active IP Right Cessation
- 1995-05-19 NZ NZ287291A patent/NZ287291A/xx unknown
- 1995-05-19 EP EP95920539A patent/EP0767783B1/en not_active Expired - Lifetime
- 1995-05-19 JP JP50217396A patent/JP3920916B2/ja not_active Expired - Fee Related
- 1995-05-19 ES ES95920539T patent/ES2121389T3/es not_active Expired - Lifetime
- 1995-05-19 CA CA002193348A patent/CA2193348C/en not_active Expired - Fee Related
- 1995-05-19 WO PCT/US1995/006317 patent/WO1995035279A1/en not_active Ceased
- 1995-05-19 KR KR1019960707303A patent/KR100371981B1/ko not_active Expired - Fee Related
- 1995-05-19 DK DK95920539T patent/DK0767783T3/da active
- 1995-05-19 DE DE69504198T patent/DE69504198T2/de not_active Expired - Fee Related
- 1995-06-14 ZA ZA954947A patent/ZA954947B/xx unknown
- 1995-06-15 TW TW084106131A patent/TW442451B/zh not_active IP Right Cessation
- 1995-06-16 IL IL11418595A patent/IL114185A/xx not_active IP Right Cessation
-
1996
- 1996-12-18 FI FI965097A patent/FI115135B/fi not_active IP Right Cessation
- 1996-12-19 NO NO965469A patent/NO307458B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69504198D1 (de) | 1998-09-24 |
| TW442451B (en) | 2001-06-23 |
| CA2193348C (en) | 1999-08-24 |
| EP0767783A1 (en) | 1997-04-16 |
| FI965097L (fi) | 1996-12-18 |
| NO965469L (no) | 1997-02-19 |
| ZA954947B (en) | 1996-01-31 |
| KR100371981B1 (ko) | 2003-06-12 |
| NO307458B1 (no) | 2000-04-10 |
| IL114185A0 (enExample) | 1995-10-31 |
| DE69504198T2 (de) | 1999-04-29 |
| JP3920916B2 (ja) | 2007-05-30 |
| EP0767783B1 (en) | 1998-08-19 |
| CN1083429C (zh) | 2002-04-24 |
| WO1995035279A1 (en) | 1995-12-28 |
| US5597845A (en) | 1997-01-28 |
| HU9603540D0 (en) | 1997-02-28 |
| FI115135B (fi) | 2005-03-15 |
| NO965469D0 (no) | 1996-12-19 |
| FI965097A0 (fi) | 1996-12-18 |
| JPH10501551A (ja) | 1998-02-10 |
| ATE169905T1 (de) | 1998-09-15 |
| AU2596195A (en) | 1996-01-15 |
| HUT75965A (en) | 1997-05-28 |
| DK0767783T3 (da) | 1999-05-25 |
| NZ287291A (en) | 1998-10-28 |
| IL114185A (en) | 1999-07-14 |
| MX9606654A (es) | 1997-12-31 |
| CA2193348A1 (en) | 1995-12-28 |
| AU691619B2 (en) | 1998-05-21 |
| CN1155883A (zh) | 1997-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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