ES2119779T3 - Solubilizacion de proteinas en formas activas. - Google Patents

Solubilizacion de proteinas en formas activas.

Info

Publication number
ES2119779T3
ES2119779T3 ES91915661T ES91915661T ES2119779T3 ES 2119779 T3 ES2119779 T3 ES 2119779T3 ES 91915661 T ES91915661 T ES 91915661T ES 91915661 T ES91915661 T ES 91915661T ES 2119779 T3 ES2119779 T3 ES 2119779T3
Authority
ES
Spain
Prior art keywords
protein
solubilization
proteins
active forms
refolding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91915661T
Other languages
English (en)
Spanish (es)
Inventor
Nirdosh Kumar Puri
Enzo Crivelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Southern Cross Biotech Pty Ltd
Original Assignee
Southern Cross Biotech Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Southern Cross Biotech Pty Ltd filed Critical Southern Cross Biotech Pty Ltd
Application granted granted Critical
Publication of ES2119779T3 publication Critical patent/ES2119779T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES91915661T 1990-09-05 1991-08-29 Solubilizacion de proteinas en formas activas. Expired - Lifetime ES2119779T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK215990 1990-09-05

Publications (1)

Publication Number Publication Date
ES2119779T3 true ES2119779T3 (es) 1998-10-16

Family

ID=3774938

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91915661T Expired - Lifetime ES2119779T3 (es) 1990-09-05 1991-08-29 Solubilizacion de proteinas en formas activas.

Country Status (8)

Country Link
EP (1) EP0547102B1 (cg-RX-API-DMAC7.html)
AT (1) ATE168115T1 (cg-RX-API-DMAC7.html)
AU (1) AU664021B2 (cg-RX-API-DMAC7.html)
CA (1) CA2090701C (cg-RX-API-DMAC7.html)
DE (1) DE69129747T2 (cg-RX-API-DMAC7.html)
DK (1) DK0547102T3 (cg-RX-API-DMAC7.html)
ES (1) ES2119779T3 (cg-RX-API-DMAC7.html)
WO (1) WO1992004382A1 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1039330C (zh) * 1992-07-02 1998-07-29 皮特曼-穆尔有限公司 一种从含有无活性蛋白的溶液中回收生物活性形式重组蛋白的方法
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
US5856126A (en) * 1993-09-22 1999-01-05 Ajinomoto Co., Inc. Peptide having anti-thrombus activity and method of producing the same
ZA955789B (en) * 1994-07-15 1996-03-11 Novo Nordisk As A method of converting a hydrophobic derivative of a polypeptide into the native form
DE10309691B4 (de) * 2003-02-28 2018-10-04 Hans-Knöll-Institut für Naturstoff-Forschung e.V. Gewinnung von löslichen Proteinen aus der Biomasse rekombinanter Mikroorganismen
MX2011013898A (es) * 2009-06-22 2012-05-22 Amgen Inc Proteínas replegadas que usan un estado de oxido-reduccion quimicamente controlado.
EP3660032B1 (en) 2009-06-25 2025-10-22 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
ES2813501T3 (es) 2013-02-12 2021-03-24 Bristol Myers Squibb Co Métodos de replegado de proteínas basados en filtración de flujo tangencial
ES2751735T3 (es) 2013-02-12 2020-04-01 Bristol Myers Squibb Co Métodos de replegado de proteínas a elevado pH
US9982012B2 (en) 2013-03-29 2018-05-29 Dr. Reddy's Laboratories Limited Refolding of granulocyte colony stimulating factor
EP3344651B1 (en) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. A process for obtaining insulin with correctly formed disulfide bonds

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6079000A (ja) * 1983-10-04 1985-05-04 Takeda Chem Ind Ltd ヒトγ型インタ−フエロン単量体の製造法
WO1986003497A1 (en) * 1984-12-06 1986-06-19 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
DE3611817A1 (de) * 1986-04-08 1987-10-15 Boehringer Mannheim Gmbh Verfahren zur renaturierung von proteinen
AU612133B2 (en) * 1987-02-20 1991-07-04 Natinco Nv Production of proteins in active forms
IL86090A (en) * 1987-04-16 1993-03-15 Cetus Oncology Corp Production of purified, biologically active, bacterially produced recombinant human csf-1
EP0295859B1 (en) * 1987-06-15 1994-11-17 Southern Cross Biotech Pty.Ltd. Production of proteins in active forms
KR890701759A (ko) * 1987-07-29 1989-12-21 스테이너 브이. 칸스태드 에스케리키아 콜라이내에서 발현된 사람 인터루킨-4의 정제방법
CA1340586C (en) * 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta
DE3832898A1 (de) * 1988-09-28 1990-04-12 Boehringer Mannheim Gmbh Praeparat von in prokaryonten exprimiertem plasminogenaktivator
DE3901719A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur herstellung eines insulinvorlaeufers
DE3901718A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Verfahren zur renaturierung falscher rekombinanten von insulinvorlaeufern
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
DE4113750A1 (de) * 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen

Also Published As

Publication number Publication date
WO1992004382A1 (en) 1992-03-19
EP0547102A4 (cg-RX-API-DMAC7.html) 1994-04-27
AU664021B2 (en) 1995-11-02
CA2090701A1 (en) 1992-03-10
DK0547102T3 (da) 1999-04-19
EP0547102B1 (en) 1998-07-08
DE69129747D1 (de) 1998-08-13
ATE168115T1 (de) 1998-07-15
AU8403591A (en) 1992-03-30
DE69129747T2 (de) 1998-11-12
CA2090701C (en) 2000-05-16
EP0547102A1 (en) 1993-06-23

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