DE69133338D1 - Bmp-5-derivate - Google Patents

Bmp-5-derivate

Info

Publication number
DE69133338D1
DE69133338D1 DE69133338T DE69133338T DE69133338D1 DE 69133338 D1 DE69133338 D1 DE 69133338D1 DE 69133338 T DE69133338 T DE 69133338T DE 69133338 T DE69133338 T DE 69133338T DE 69133338 D1 DE69133338 D1 DE 69133338D1
Authority
DE
Germany
Prior art keywords
bmp
derivatives
protein
bone
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133338T
Other languages
English (en)
Other versions
DE69133338T2 (de
Inventor
M Wozney
A Rosen
A Wang
J Celeste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Application granted granted Critical
Publication of DE69133338D1 publication Critical patent/DE69133338D1/de
Publication of DE69133338T2 publication Critical patent/DE69133338T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69133338T 1990-09-26 1991-09-26 Bmp-5-derivate Expired - Lifetime DE69133338T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58822790A 1990-09-26 1990-09-26
US588227 1990-09-26
PCT/US1991/007069 WO1992005199A1 (en) 1990-09-26 1991-09-26 Bmp-5 derivatives

Publications (2)

Publication Number Publication Date
DE69133338D1 true DE69133338D1 (de) 2003-12-11
DE69133338T2 DE69133338T2 (de) 2004-04-15

Family

ID=24353000

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69133338T Expired - Lifetime DE69133338T2 (de) 1990-09-26 1991-09-26 Bmp-5-derivate

Country Status (4)

Country Link
EP (1) EP0550625B1 (de)
AT (1) ATE253589T1 (de)
DE (1) DE69133338T2 (de)
WO (1) WO1992005199A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
DE69434875T2 (de) * 1993-05-12 2007-09-06 Genetics Institute, LLC, Cambridge BMP-11 Zusammenstellungen
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
KR20000064752A (ko) 1996-03-22 2000-11-06 더 제네랄 호스피탈 코포레이션 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
ATE533781T1 (de) 2005-05-27 2011-12-15 Bbs Bioactive Bone Substitutes Oy Heparin-bindungsstelle enthaltendes knochenmorphogenetisches protein 6 und osteogene vorrichtungen und pharmazeutische produkte, die diese enthalten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
KR900700617A (ko) * 1988-04-08 1990-08-16 브루스 엠. 에이센 뼈 및 연골 유도 조성물
ES2113857T3 (es) * 1989-03-28 1998-05-16 Genetics Inst Composiciones osteoinductoras.

Also Published As

Publication number Publication date
ATE253589T1 (de) 2003-11-15
WO1992005199A1 (en) 1992-04-02
DE69133338T2 (de) 2004-04-15
EP0550625A1 (de) 1993-07-14
EP0550625B1 (de) 2003-11-05

Similar Documents

Publication Publication Date Title
DK0536186T3 (da) Knogle- og brusk-dannelsesfremkaldende proteiner
DK0429570T3 (da) Osteoinducerende præparater
ATE223486T1 (de) Bmp-9 zusammensetzungen
CA2108770A1 (en) Bmp-9 compositions
DE69433742D1 (de) Bmp-10 zusammensetzungen
DE69028535D1 (de) Herstellung des vaskulären endothelialen zellwachstumsfaktors
DE69133338D1 (de) Bmp-5-derivate
ATE177954T1 (de) Verfahren zur behandlung von knochengeweben und implantierbare biomaterialien dafür
DE69027865D1 (de) ZUSAMMENSETZUNGEN enthaltend omega Conotoxin Peptide Derivate und deren Verwendung ZUR BEHANDLUNG VON ISCHÄMIE-ARTIGEN NEURONALEN SCHÄDIGUNGEN
ATE153696T1 (de) Verfahren und desoxyribonukleinsäure zur herstellung von gewebefaktor-protein
ATE349428T1 (de) Prostaglandinagoniste und deren verwendung zur behandlung von knochenerkrankungen
DE69233022D1 (de) Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
DK53497A (da) Osteoinduktive præparater
ATE242960T1 (de) Vorrichtung und verfahren zur photoaktivierung
DE69114653D1 (de) Sterilisierendes Gemisch und Verfahren zur Sterilisation.
DE3788231D1 (de) Kosmetisches mittel und zusammensetzung zur behandlung der haut.
NO931413D0 (no) Fremgangsmaater og preparater for behandling av celleproliferasjonssykdommer
ES2044170T3 (es) Sal de estroncio, su procedimiento de preparacion y las composiciones farmaceuticas que la contienen.
DE59410340D1 (de) Verwendung von Bradykinin-Antagonisten zur Behandlung von Viruserkrankungen
ES291814Y (es) Protesis perfeccionada de osteosintesis para el tratamiento de las fracturas del femur

Legal Events

Date Code Title Description
8364 No opposition during term of opposition