ES2117042T3 - Sistemas para administrar farmacos transdermicamente utilizando esteres de sorbitan como intensificadores de la penetrabilidad en la piel. - Google Patents
Sistemas para administrar farmacos transdermicamente utilizando esteres de sorbitan como intensificadores de la penetrabilidad en la piel.Info
- Publication number
- ES2117042T3 ES2117042T3 ES92902108T ES92902108T ES2117042T3 ES 2117042 T3 ES2117042 T3 ES 2117042T3 ES 92902108 T ES92902108 T ES 92902108T ES 92902108 T ES92902108 T ES 92902108T ES 2117042 T3 ES2117042 T3 ES 2117042T3
- Authority
- ES
- Spain
- Prior art keywords
- systems
- administering
- pharmacs
- transdermically
- intensifiers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 title 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000006 Nitroglycerin Substances 0.000 abstract 3
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- -1 sorbitan ester Chemical class 0.000 abstract 1
- 230000037317 transdermal delivery Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
SE DAN A CONOCER COMPOSICIONES ACRECENTADORAS DE PERMEABILIDAD CUTANEA QUE INCREMENTAN LA PERMEABILIDAD DE LA PIEL PARA LA ADMINISTRACION CUTANEA DE AGENTES ACTIVOS FARMACOLOGICOS. LAS COMPOSICIONES CONTIENEN UN ESTER SORBITANO ADICIONALMENTE A LOS AGENTES ACTIVOS SELECCIONADOS FARMACOLOGICAMENTE Y PUEDEN CONTENER TAMBIEN ALCOHOL C1 ETODOS Y SISTEMAS DE SUMINISTRO DE MEDICAMENTOS CON SISTEMAS QUE DISPONEN DE UNA MATRIZ LAMINADA O DE UN RECIPIENTE DE MEDICAMENTO. EN EL RECIPIENTE DE MEDICAMENTOS DEL TIPO DE LA FIGURA 1, DESIGNADO CON EL NUMERO (10) SE DISPONE DE UNA CAPA (12) TRASERA, UN RECIPIENTE (14) DE MEDICAMENTOS Y UN REVESTIMIENTO (16A) Y (16B) DE LIBERACION DE DOS PIEZAS. EN EL TIPO LAMINADO, DESIGNADO CON EL NUMERO (18) EN LA FIGURA 2, SE HA PREVISTO UNA PELICULA (20) TRASERA, UN RECIPIENTE (22), UNA CAPA (24) PERFILADA ANULAR Y UNA CAPA (26) DE MEMBRANA, ADHESIVA Y UN REVESTIMIENTO INTERIOR SELLABLE.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/625,906 US5202125A (en) | 1990-12-10 | 1990-12-10 | Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes |
US07/702,043 US5122383A (en) | 1991-05-17 | 1991-05-17 | Sorbitan esters as skin permeation enhancers |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2117042T3 true ES2117042T3 (es) | 1998-08-01 |
Family
ID=27090035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92902108T Expired - Lifetime ES2117042T3 (es) | 1990-12-10 | 1991-12-06 | Sistemas para administrar farmacos transdermicamente utilizando esteres de sorbitan como intensificadores de la penetrabilidad en la piel. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5202125A (es) |
EP (1) | EP0561983B1 (es) |
JP (1) | JP2604097B2 (es) |
AT (1) | ATE167384T1 (es) |
AU (1) | AU656755B2 (es) |
CA (1) | CA2098196C (es) |
DE (1) | DE69129632T2 (es) |
DK (1) | DK0561983T3 (es) |
ES (1) | ES2117042T3 (es) |
GR (1) | GR3027652T3 (es) |
HK (1) | HK1013790A1 (es) |
PT (1) | PT99749B (es) |
WO (1) | WO1992010154A1 (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5762952A (en) * | 1993-04-27 | 1998-06-09 | Hercon Laboratories Corporation | Transdermal delivery of active drugs |
US5613958A (en) * | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
CN1170360A (zh) * | 1994-12-21 | 1998-01-14 | 瑟垃技术有限公司 | 具有粘性贴面和剥离密封圆片的经皮输送系统 |
US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
IL116539A (en) * | 1995-01-06 | 2002-02-10 | Noven Pharma | Preparations given through the skin of unstable anti-acid drugs |
US6024974A (en) * | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
US7094422B2 (en) | 1996-02-19 | 2006-08-22 | Acrux Dds Pty Ltd. | Topical delivery of antifungal agents |
US6916486B2 (en) | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of analgesics |
US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
US6916487B2 (en) | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of antiemetics |
AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
US6998138B2 (en) | 1996-02-19 | 2006-02-14 | Acrux Dds Pty. Ltd. | Topical delivery of anti-alopecia agents |
HU0200901D0 (es) * | 1996-06-20 | 2002-08-28 | Lavipharm Sa | |
GR1002807B (el) * | 1996-06-20 | 1997-11-13 | Lavipharm A.E. | Συστημα για την τοπικη θεραπεια της ακμης και μεθοδος παραγωγης του |
US6440980B1 (en) * | 1996-09-17 | 2002-08-27 | Avanir Pharmaceuticals | Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs |
JP2001503062A (ja) * | 1996-10-30 | 2001-03-06 | セラテック・インコーポレーテッド | 透過促進剤としての乳酸の脂肪酸エステルの塩 |
JP2002518417A (ja) * | 1998-06-25 | 2002-06-25 | ラヴィファム ラボラトリーズ インコーポレーテッド | 勃起機能不全の治療装具及び方法 |
US7087240B1 (en) | 1998-06-25 | 2006-08-08 | Lavipharm Laboratories Inc. | Device and method for the treatment of erectile dysfunction |
CN1320145A (zh) | 1998-07-29 | 2001-10-31 | 帝人株式会社 | 粘着性组合物、以及含有该组合物的透湿性粘着带、粘着性药物组合物以及粘着带制剂 |
CN1192766C (zh) * | 1998-10-23 | 2005-03-16 | 伊迪亚股份公司 | 开发、测试和使用用于改进的有效负载和可控制性解缔/缔合速度的大分子和复合聚集体的缔合物的方法 |
DK1031347T3 (da) | 1999-01-27 | 2002-07-08 | Idea Ag | Transnasal transport/immunisering med meget tilpasselige bærere |
ES2173678T3 (es) | 1999-01-27 | 2002-10-16 | Idea Ag | Vacunacion no invasiva a traves de la piel. |
DE19925338A1 (de) * | 1999-06-02 | 2000-12-07 | Lohmann Therapie Syst Lts | Substratabschnitte mit erhöhter Lagerstabilität während ihrer Lagerung in Beutelverpackung, sowie Verfahren zu ihrer Herstellung |
MXPA02000053A (es) * | 1999-07-05 | 2003-07-21 | Idea Ag | Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables. |
GB9917290D0 (en) * | 1999-07-22 | 1999-09-22 | Glaxo Wellcome Spa | Pharmaceutical composition |
US7083781B2 (en) * | 1999-08-19 | 2006-08-01 | Lavipharm S.A. | Film forming polymers, methods of use, and devices and applications thereof |
GB9930875D0 (en) * | 1999-12-24 | 2000-02-23 | Jehan David | Patch for transdermal therapy |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US20040105881A1 (en) * | 2002-10-11 | 2004-06-03 | Gregor Cevc | Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin |
US7105263B2 (en) * | 2003-12-30 | 2006-09-12 | Samsung Electronics Company | Dry toner comprising encapsulated pigment, methods and uses |
US20060008432A1 (en) * | 2004-07-07 | 2006-01-12 | Sebastiano Scarampi | Gilsonite derived pharmaceutical delivery compositions and methods: nail applications |
JP2008519784A (ja) * | 2004-11-12 | 2008-06-12 | イデア アクチェンゲゼルシャフト | 皮膚状態の治療における拡張表面凝集体 |
US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
ITMI20050477A1 (it) | 2005-03-23 | 2006-09-24 | Bouty S P A | Cerotto transdermico |
RS52671B (en) | 2005-10-12 | 2013-06-28 | Unimed Pharmaceuticals Llc | IMPROVED TESTOSTERON GEL AND USE PROCEDURE |
ES2499067T3 (es) * | 2005-10-13 | 2014-09-26 | Nitto Denko Corporation | Preparación transdérmica de nicotina y método de producción de la misma |
JP5005277B2 (ja) * | 2006-07-13 | 2012-08-22 | 日東電工株式会社 | 貼付剤および貼付製剤 |
EP2247277A2 (en) * | 2008-01-25 | 2010-11-10 | B & T S.r.l. | Use of transesterified olive oil in the cosmetic field |
US9302085B2 (en) * | 2009-03-11 | 2016-04-05 | The Regents Of The University Of California | Methods and compositions for facilitating arterial access |
DE102010000661A1 (de) * | 2010-01-04 | 2011-07-07 | Acino Ag, 83714 | Verfahren und Vorrichtung zur Herstellung einer überlappenden Schutzfolie für ein transdermales therapeutisches System |
CN113125596B (zh) * | 2021-04-07 | 2023-01-13 | 马应龙药业集团股份有限公司 | 一种高效液相色谱法测定硝酸甘油软膏中有关物质的方法 |
US20230414551A1 (en) * | 2022-06-27 | 2023-12-28 | Permeatus, Inc. | Topical formulations of nitroglycerin |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL61721A (en) * | 1980-12-16 | 1984-03-30 | Blank Izhak | Nitroglycerin preparations |
CA1218604A (en) * | 1981-07-08 | 1987-03-03 | Alec D. Keith | Trinitroglycerol sustained release vehicles and preparations therefrom |
US4559222A (en) * | 1983-05-04 | 1985-12-17 | Alza Corporation | Matrix composition for transdermal therapeutic system |
US4637930A (en) * | 1984-02-08 | 1987-01-20 | Yamanouchi Pharmaceutical Co, Ltd. | Transdermal formulation of nicardipine hydrochloride |
JPS60174716A (ja) * | 1984-02-21 | 1985-09-09 | Yamanouchi Pharmaceut Co Ltd | パツチ剤 |
US4879119A (en) * | 1984-02-21 | 1989-11-07 | Yamanouchi Pharmaceutical Co., Ltd. | Patch |
EP0190262B1 (en) * | 1984-07-24 | 1990-12-27 | Key Pharmaceuticals, Inc. | Adhesive transdermal dosage layer |
EP0184910B1 (en) * | 1984-11-15 | 1992-09-30 | Hercon Laboratories Corporation | Device for controlled release drug delivery |
US4751087A (en) * | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
US4615699A (en) * | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
US4690683A (en) * | 1985-07-02 | 1987-09-01 | Rutgers, The State University Of New Jersey | Transdermal varapamil delivery device |
US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
US4836970A (en) * | 1987-01-30 | 1989-06-06 | Robbins Edward S Iii | Method of extrusion blow-molding container having upper and lower sections of different thickness |
US4983395A (en) * | 1987-11-12 | 1991-01-08 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
WO1990009784A1 (en) * | 1989-02-28 | 1990-09-07 | Teijin Limited | Poultice and preparation thereof |
-
1990
- 1990-12-10 US US07/625,906 patent/US5202125A/en not_active Expired - Lifetime
-
1991
- 1991-12-06 CA CA002098196A patent/CA2098196C/en not_active Expired - Lifetime
- 1991-12-06 EP EP92902108A patent/EP0561983B1/en not_active Expired - Lifetime
- 1991-12-06 WO PCT/US1991/009215 patent/WO1992010154A1/en active IP Right Grant
- 1991-12-06 ES ES92902108T patent/ES2117042T3/es not_active Expired - Lifetime
- 1991-12-06 AT AT92902108T patent/ATE167384T1/de not_active IP Right Cessation
- 1991-12-06 AU AU91413/91A patent/AU656755B2/en not_active Ceased
- 1991-12-06 JP JP4502721A patent/JP2604097B2/ja not_active Expired - Lifetime
- 1991-12-06 DK DK92902108T patent/DK0561983T3/da active
- 1991-12-06 DE DE69129632T patent/DE69129632T2/de not_active Expired - Lifetime
- 1991-12-10 PT PT99749A patent/PT99749B/pt active IP Right Grant
-
1992
- 1992-07-24 US US07/919,296 patent/US5302395A/en not_active Expired - Lifetime
-
1998
- 1998-08-14 GR GR980401827T patent/GR3027652T3/el unknown
- 1998-12-24 HK HK98115310A patent/HK1013790A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2604097B2 (ja) | 1997-04-23 |
AU9141391A (en) | 1992-07-08 |
EP0561983A1 (en) | 1993-09-29 |
GR3027652T3 (en) | 1998-11-30 |
DE69129632T2 (de) | 1998-11-05 |
PT99749A (pt) | 1993-04-30 |
WO1992010154A1 (en) | 1992-06-25 |
AU656755B2 (en) | 1995-02-16 |
PT99749B (pt) | 1999-05-31 |
CA2098196C (en) | 1997-01-21 |
EP0561983A4 (en) | 1993-10-20 |
DE69129632D1 (de) | 1998-07-23 |
CA2098196A1 (en) | 1992-06-10 |
US5302395A (en) | 1994-04-12 |
EP0561983B1 (en) | 1998-06-17 |
DK0561983T3 (da) | 1998-10-19 |
HK1013790A1 (en) | 1999-09-10 |
ATE167384T1 (de) | 1998-07-15 |
US5202125A (en) | 1993-04-13 |
JPH06503576A (ja) | 1994-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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