ES2113980T3 - Ligandos solubles para cd40. - Google Patents
Ligandos solubles para cd40.Info
- Publication number
- ES2113980T3 ES2113980T3 ES93114153T ES93114153T ES2113980T3 ES 2113980 T3 ES2113980 T3 ES 2113980T3 ES 93114153 T ES93114153 T ES 93114153T ES 93114153 T ES93114153 T ES 93114153T ES 2113980 T3 ES2113980 T3 ES 2113980T3
- Authority
- ES
- Spain
- Prior art keywords
- soluble
- soluble links
- links
- soluble ligands
- promoting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/505—CD4; CD8
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Catalysts (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A LIGANDOS SOLUBLES PARA EL ANTIGENO DE CELULAS B, Y EN PARTICULAR, A PROTEINA GP39 HUMANA Y LIGANDOS SOLUBLES DERIVADOS DE ESTA QUE PUEDEN SERUSADAS EN METODOS DE PROMOCION DE PROLIFERACION DE CELULAS B.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/940,605 US5540926A (en) | 1992-09-04 | 1992-09-04 | Soluble and its use in B cell stimulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2113980T3 true ES2113980T3 (es) | 1998-05-16 |
Family
ID=25475138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93114153T Expired - Lifetime ES2113980T3 (es) | 1992-09-04 | 1993-09-03 | Ligandos solubles para cd40. |
Country Status (17)
Country | Link |
---|---|
US (2) | US5540926A (es) |
EP (1) | EP0585943B1 (es) |
JP (1) | JP3529815B2 (es) |
KR (1) | KR100319126B1 (es) |
AT (1) | ATE163195T1 (es) |
AU (1) | AU677788B2 (es) |
CA (1) | CA2105552C (es) |
DE (1) | DE69316948T2 (es) |
DK (1) | DK0585943T3 (es) |
ES (1) | ES2113980T3 (es) |
FI (1) | FI113969B (es) |
GR (1) | GR3026100T3 (es) |
HU (1) | HU215949B (es) |
IL (1) | IL106896A (es) |
NO (1) | NO311808B1 (es) |
NZ (1) | NZ248569A (es) |
ZA (1) | ZA936491B (es) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5961974A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same |
US7405270B2 (en) * | 1991-10-25 | 2008-07-29 | Immunex Corporation | CD40-Ligand lacking native-pattern glycosylation |
US5981724A (en) * | 1991-10-25 | 1999-11-09 | Immunex Corporation | DNA encoding CD40 ligand, a cytokine that binds CD40 |
ES2198025T3 (es) * | 1991-10-25 | 2004-01-16 | Immunex Corporation | Anticuerpos contra cd40-l. |
US5962406A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
CA2153806C (en) * | 1993-01-22 | 2005-11-08 | Melanie K. Spriggs | Detection and treatment of mutations in a cd40 ligand gene |
US5869049A (en) * | 1993-09-02 | 1999-02-09 | Trustees Of Dartmouth College | Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists |
CN1127351C (zh) * | 1993-09-02 | 2003-11-12 | 达特茅斯学院理事 | 诱导抗原特异性t细胞耐受的方法 |
US5874085A (en) * | 1993-11-10 | 1999-02-23 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Vaccine for enhanced production of IgA antibodies |
AU1059095A (en) * | 1993-11-24 | 1995-06-13 | Australian National University, The | Treatment of viral disease with cd40l peptide |
JPH09507074A (ja) * | 1993-12-23 | 1997-07-15 | イミュネックス・コーポレーション | Cd40を発現する腫瘍細胞を特徴とする疾患の予防又は治療方法 |
US5683693A (en) * | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
MX9605088A (es) | 1994-04-28 | 1997-08-30 | Boehringer Ingelheim Pharma | Metodos para proliferar y diferenciar celulas b y sus usos. |
GB9425060D0 (en) * | 1994-12-13 | 1995-02-08 | Univ Birmingham | Carcinoma treatment |
US5645837A (en) * | 1995-01-17 | 1997-07-08 | Thomas Jefferson University | Peptides that inhibit T cell activation and methods of using the same |
AU2556195A (en) | 1995-03-13 | 1996-10-02 | Regents Of The University Of Michigan, The | CD40 binding compositions and methods of using same |
DK0832229T3 (da) * | 1995-06-07 | 2004-05-03 | Immunex Corp | CD40L-mutein |
DK0833847T3 (da) * | 1995-06-22 | 2003-12-29 | Biogen Inc | Krystaller af fregmenter af CD40-ligand og deres anvendelse |
US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
US6132978A (en) * | 1995-12-19 | 2000-10-17 | National Jewish Medical And Research Center | Method to regulate CD40 signaling |
WO1997034634A1 (en) * | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
WO1998001538A1 (en) * | 1996-07-10 | 1998-01-15 | Immunex Corporation | Method of activating dendritic cells |
US6017527A (en) * | 1996-07-10 | 2000-01-25 | Immunex Corporation | Activated dendritic cells and methods for their activation |
US7070771B1 (en) | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
JP2001508450A (ja) * | 1997-01-10 | 2001-06-26 | バイオジェン インコーポレイテッド | 抗cd40l化合物の治療学的投与の方法 |
CA2223225A1 (en) | 1997-11-28 | 1999-05-28 | Canadian Red Cross Society | Method for inhibiting in vivo immune response |
US20050031611A1 (en) * | 1998-05-08 | 2005-02-10 | Beth Israel Deaconess Medical Center | Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis |
EP1181050A4 (en) | 1999-04-30 | 2005-05-18 | Jolla Inst Allergy Immunolog | METHODS FOR PREVENTING THE REACTIVATION OF LATENT VIRUSES AND CONTROLLING VIRUS REPLICATION |
MXPA01011279A (es) | 1999-05-07 | 2002-07-02 | Genentech Inc | Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b. |
US6946129B1 (en) * | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
KR20020027490A (ko) * | 1999-07-12 | 2002-04-13 | 제넨테크, 인크. | Cd20에 결합하는 길항제를 사용한 외래 항원에 대한면역 반응 차단 방법 |
AU6934600A (en) * | 1999-08-27 | 2001-03-26 | Board Of Regents, The University Of Texas System | Cd40 ligand and cd40 agonist compositions and methods of use |
EP1246643A4 (en) * | 1999-10-14 | 2005-05-11 | Jeffery A Ledbetter | DNA VACCINES ENCODING ANTIGEN ASSOCIATED WITH CD40-BINDING DOMAIN |
US20030077263A1 (en) * | 1999-10-29 | 2003-04-24 | Immunex Corporation | Method of activating dendritic cells |
US20020028178A1 (en) * | 2000-07-12 | 2002-03-07 | Nabil Hanna | Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications |
AU2062601A (en) * | 1999-12-06 | 2001-06-12 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Peptides that stabilize protein antigens and enhance presentation to CD8+ T cells |
US20110041190A1 (en) * | 2002-10-31 | 2011-02-17 | Tykocinski Mark L | Novel chimeric proteins |
EP1255558B1 (en) * | 2000-02-16 | 2006-06-14 | Genentech, Inc. | Anti-april antibodies and hybridoma cells |
AU2001251612A1 (en) | 2000-04-14 | 2001-10-30 | Millennium Pharmaceuticals, Inc. | Roles of jak/stat family members in tolerance induction |
JP2004508420A (ja) * | 2000-09-18 | 2004-03-18 | アイデック ファーマスーティカルズ コーポレイション | B細胞枯渇抗体/免疫調節性抗体の組合せを用いて自己免疫疾患を治療するための併用療法 |
US7786257B2 (en) * | 2000-12-18 | 2010-08-31 | University Of Kansas | Signal-1/signal-2 bifunctional peptide inhibitors |
US20030103971A1 (en) * | 2001-11-09 | 2003-06-05 | Kandasamy Hariharan | Immunoregulatory antibodies and uses thereof |
US20030211107A1 (en) * | 2002-01-31 | 2003-11-13 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
US20070065436A1 (en) * | 2001-01-31 | 2007-03-22 | Biogen Idec Inc. | Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies |
US20020159996A1 (en) | 2001-01-31 | 2002-10-31 | Kandasamy Hariharan | Use of CD23 antagonists for the treatment of neoplastic disorders |
EA200601861A1 (ru) * | 2001-08-03 | 2007-02-27 | Дженентек, Инк. | ПОЛИПЕПТИДЫ TACIs И BR3 И ИХ ПРИМЕНЕНИЕ |
CA2461905A1 (en) * | 2001-09-27 | 2003-04-10 | Board Of Regents, The University Of Texas System | Combined compositions and methods for tumor vasculature coagulation and treatment |
US7786282B2 (en) * | 2001-12-06 | 2010-08-31 | The Regents Of The University Of California | Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
US20030180292A1 (en) * | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
CN1692127A (zh) * | 2002-07-25 | 2005-11-02 | 健泰科生物技术公司 | Taci抗体及其用途 |
CA2502552C (en) * | 2002-10-17 | 2019-02-12 | Genmab A/S | Human monoclonal antibodies against cd20 |
WO2004083244A2 (en) * | 2003-03-19 | 2004-09-30 | Isogenis, Inc. | Specific inhibition of allograft rejection |
US20050163775A1 (en) * | 2003-06-05 | 2005-07-28 | Genentech, Inc. | Combination therapy for B cell disorders |
MXPA05013117A (es) * | 2003-06-05 | 2006-03-17 | Genentech Inc | Terapia de combinacion para trastornos de celulas-b. |
EP1740946B1 (en) * | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
EP1778296B1 (en) * | 2004-07-20 | 2012-06-06 | Isogenis, Inc. | Specific inhibition of autoimmunity and diseases associated with autoantigens |
US8647625B2 (en) | 2004-07-26 | 2014-02-11 | Biogen Idec Ma Inc. | Anti-CD154 antibodies |
EP1835027B1 (en) * | 2004-12-07 | 2015-02-25 | Toray Industries, Inc. | Novel cancer antigen peptide and the use thereof |
EP2312315A1 (en) | 2005-05-18 | 2011-04-20 | Novartis AG | Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component |
AU2006249305B2 (en) | 2005-05-26 | 2012-10-18 | Genentech, Inc. | Humanized anti-CD40 antibodies and their methods of use |
AU2006318539B2 (en) * | 2005-11-23 | 2012-09-13 | Genentech, Inc. | Methods and compositions related to B cell assays |
EP3097926B1 (en) | 2007-11-01 | 2019-10-02 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses to eimeria |
JP5608100B2 (ja) * | 2008-02-08 | 2014-10-15 | メディミューン,エルエルシー | 低下したFcリガンド親和性を有する抗IFNAR1抗体 |
US20100034807A1 (en) * | 2008-07-25 | 2010-02-11 | Matthew Moyle | Methods and compositions for discovery of target-specific antibodies using antibody repertoire array (ara) |
EP2321345A1 (en) * | 2008-07-28 | 2011-05-18 | Emergent Product Development Seattle, LLC | Multi-specific binding proteins targeting b cell disorders |
WO2010033722A2 (en) | 2008-09-17 | 2010-03-25 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
EP2483301A1 (en) | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
AU2011309689B2 (en) | 2010-09-28 | 2015-01-15 | Hadasit Medical Research Services & Development Ltd. | Compositions and methods for treatment of hematological malignancies |
ES2675317T3 (es) | 2012-03-02 | 2018-07-10 | The Regents Of The University Of California | Expansión de linfocitos T reguladores reactivos a aloantígeno |
ES2968398T3 (es) | 2013-02-14 | 2024-05-09 | Univ Arkansas | Composiciones y métodos para potenciar las respuestas inmunitarias a Eimeria o limitar la infección por Eimeria |
US20160075766A1 (en) | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
GB201317928D0 (en) | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Molecule |
ES2944563T3 (es) * | 2014-05-19 | 2023-06-22 | Hoffmann La Roche | Procedimiento para producir anticuerpos usando linfocitos B ovinos y usos de los mismos |
WO2017079202A1 (en) | 2015-11-02 | 2017-05-11 | Board Of Regents, The University Of Texas System | Methods of cd40 activation and immune checkpoint blockade |
MX2022002747A (es) | 2019-09-10 | 2022-04-06 | Obsidian Therapeutics Inc | Proteinas de fusion de ca2-il15 para regulacion ajustable. |
Family Cites Families (10)
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---|---|---|---|---|
WO1989008114A1 (en) * | 1988-02-25 | 1989-09-08 | The General Hospital Corporation | Rapid immunoselection cloning method |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
AU5355790A (en) * | 1989-04-19 | 1990-11-16 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
US5227167A (en) * | 1991-06-11 | 1993-07-13 | Alza Corporation | Long-term delivery device including hydrophobic loading dose |
ES2198025T3 (es) * | 1991-10-25 | 2004-01-16 | Immunex Corporation | Anticuerpos contra cd40-l. |
US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
IL104684A0 (en) * | 1992-02-14 | 1993-06-10 | Bristol Myers Squibb Co | The cd40cr receptor and ligands therefor |
AU5098493A (en) * | 1992-08-21 | 1994-03-15 | Schering Corporation | Cd40 ligand, anti cd40 antibodies, and soluble cd40 |
US5540926A (en) * | 1992-09-04 | 1996-07-30 | Bristol-Myers Squibb Company | Soluble and its use in B cell stimulation |
US5565321A (en) * | 1993-01-22 | 1996-10-15 | Immunex Corporation | Detection of mutations in a CD40 ligand gene |
-
1992
- 1992-09-04 US US07/940,605 patent/US5540926A/en not_active Expired - Lifetime
-
1993
- 1993-09-02 ZA ZA936491A patent/ZA936491B/xx unknown
- 1993-09-02 NZ NZ248569A patent/NZ248569A/en not_active IP Right Cessation
- 1993-09-02 NO NO19933126A patent/NO311808B1/no not_active IP Right Cessation
- 1993-09-03 ES ES93114153T patent/ES2113980T3/es not_active Expired - Lifetime
- 1993-09-03 CA CA002105552A patent/CA2105552C/en not_active Expired - Lifetime
- 1993-09-03 AT AT93114153T patent/ATE163195T1/de active
- 1993-09-03 DE DE69316948T patent/DE69316948T2/de not_active Expired - Lifetime
- 1993-09-03 EP EP93114153A patent/EP0585943B1/en not_active Expired - Lifetime
- 1993-09-03 IL IL10689693A patent/IL106896A/xx not_active IP Right Cessation
- 1993-09-03 KR KR1019930017670A patent/KR100319126B1/ko not_active IP Right Cessation
- 1993-09-03 AU AU46120/93A patent/AU677788B2/en not_active Expired
- 1993-09-03 DK DK93114153T patent/DK0585943T3/da active
- 1993-09-03 HU HU9302484A patent/HU215949B/hu unknown
- 1993-09-03 FI FI933862A patent/FI113969B/fi not_active IP Right Cessation
- 1993-09-06 JP JP24358193A patent/JP3529815B2/ja not_active Expired - Lifetime
-
1996
- 1996-07-30 US US08/690,096 patent/US5945513A/en not_active Expired - Lifetime
-
1998
- 1998-02-12 GR GR980400208T patent/GR3026100T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06315383A (ja) | 1994-11-15 |
EP0585943A3 (en) | 1994-07-06 |
KR940007179A (ko) | 1994-04-26 |
EP0585943B1 (en) | 1998-02-11 |
HU215949B (hu) | 1999-03-29 |
NO933126L (no) | 1994-03-07 |
AU4612093A (en) | 1994-03-10 |
DE69316948T2 (de) | 1998-10-01 |
CA2105552A1 (en) | 1994-03-05 |
HU9302484D0 (en) | 1993-11-29 |
EP0585943A2 (en) | 1994-03-09 |
NZ248569A (en) | 1995-10-26 |
ATE163195T1 (de) | 1998-02-15 |
JP3529815B2 (ja) | 2004-05-24 |
AU677788B2 (en) | 1997-05-08 |
IL106896A (en) | 2005-12-18 |
US5540926A (en) | 1996-07-30 |
IL106896A0 (en) | 1993-12-28 |
KR100319126B1 (ko) | 2002-05-13 |
ZA936491B (en) | 1994-03-25 |
DK0585943T3 (da) | 1998-09-23 |
FI933862A0 (fi) | 1993-09-03 |
NO311808B1 (no) | 2002-01-28 |
CA2105552C (en) | 2009-08-18 |
FI113969B (fi) | 2004-07-15 |
NO933126D0 (no) | 1993-09-02 |
HUT69977A (en) | 1995-09-28 |
FI933862A (fi) | 1994-03-05 |
GR3026100T3 (en) | 1998-05-29 |
US5945513A (en) | 1999-08-31 |
DE69316948D1 (de) | 1998-03-19 |
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