DK0833847T3 - Krystaller af fregmenter af CD40-ligand og deres anvendelse - Google Patents

Krystaller af fregmenter af CD40-ligand og deres anvendelse

Info

Publication number
DK0833847T3
DK0833847T3 DK96922527T DK96922527T DK0833847T3 DK 0833847 T3 DK0833847 T3 DK 0833847T3 DK 96922527 T DK96922527 T DK 96922527T DK 96922527 T DK96922527 T DK 96922527T DK 0833847 T3 DK0833847 T3 DK 0833847T3
Authority
DK
Denmark
Prior art keywords
ligand
crystals
fragments
relates
optimize
Prior art date
Application number
DK96922527T
Other languages
English (en)
Inventor
Juswinder Singh
Mihail N Karpusas
David W Thomas
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc filed Critical Biogen Inc
Application granted granted Critical
Publication of DK0833847T3 publication Critical patent/DK0833847T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
DK96922527T 1995-06-22 1996-06-21 Krystaller af fregmenter af CD40-ligand og deres anvendelse DK0833847T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44895P 1995-06-22 1995-06-22
PCT/US1996/010664 WO1997000895A1 (en) 1995-06-22 1996-06-21 Crystals of fragments of cd40 ligand and their use

Publications (1)

Publication Number Publication Date
DK0833847T3 true DK0833847T3 (da) 2003-12-29

Family

ID=21691579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96922527T DK0833847T3 (da) 1995-06-22 1996-06-21 Krystaller af fregmenter af CD40-ligand og deres anvendelse

Country Status (11)

Country Link
EP (1) EP0833847B1 (da)
JP (2) JPH11508262A (da)
AT (1) ATE250630T1 (da)
AU (1) AU6337296A (da)
CA (1) CA2224812A1 (da)
DE (1) DE69630120T2 (da)
DK (1) DK0833847T3 (da)
ES (1) ES2202455T3 (da)
HK (1) HK1010085A1 (da)
PT (1) PT833847E (da)
WO (1) WO1997000895A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5834228A (en) * 1997-02-13 1998-11-10 Merck & Co., Inc. Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex
EP1754490A3 (en) 1997-06-20 2010-01-20 Biogen Idec MA Inc. CD 154 blockage therapy for pancreatic islet tissue transplantation in primates
US6492410B1 (en) 1998-05-12 2002-12-10 Warner-Lambert Company Combinations of protein farnesyltransferase and HMG CoA reductase inhibitors and their use to treat cancer
AU8867501A (en) * 2000-09-01 2002-03-13 Biogen Inc Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design
HUP0500733A3 (en) 2001-02-09 2010-01-28 Genentech Inc Crystallization of igf-1
WO2013036829A1 (en) 2011-09-09 2013-03-14 Genentech, Inc Treatment of th17 mediated inflammatory diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233402T3 (de) * 1991-10-25 2009-06-25 Immunex Corp., Seattle Neue cytokine
CA2089229C (en) * 1992-02-14 2010-04-13 Alejandro A. Aruffo Cd40cr receptor and ligands therefor
US5540926A (en) * 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
DE69433399T2 (de) * 1993-01-22 2004-10-14 Immunex Corp., Seattle Detektion und behandlung von mutationen in einem gen für einen cd40-liganden

Also Published As

Publication number Publication date
CA2224812A1 (en) 1997-01-09
ATE250630T1 (de) 2003-10-15
PT833847E (pt) 2004-02-27
AU6337296A (en) 1997-01-22
HK1010085A1 (en) 1999-06-11
ES2202455T3 (es) 2004-04-01
DE69630120D1 (de) 2003-10-30
EP0833847B1 (en) 2003-09-24
DE69630120T2 (de) 2004-04-08
EP0833847A1 (en) 1998-04-08
JP2006188541A (ja) 2006-07-20
WO1997000895A1 (en) 1997-01-09
JPH11508262A (ja) 1999-07-21

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