ES2113020T3 - Analogos de vitamina d3. - Google Patents

Analogos de vitamina d3.

Info

Publication number
ES2113020T3
ES2113020T3 ES94114668T ES94114668T ES2113020T3 ES 2113020 T3 ES2113020 T3 ES 2113020T3 ES 94114668 T ES94114668 T ES 94114668T ES 94114668 T ES94114668 T ES 94114668T ES 2113020 T3 ES2113020 T3 ES 2113020T3
Authority
ES
Spain
Prior art keywords
cholecalciferol
ene
dihydroxy
trihydroxy
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94114668T
Other languages
English (en)
Inventor
Arthur Mclane John
G Reddy Satiyanarayama
Radoje Uskokovic Milan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2113020T3 publication Critical patent/ES2113020T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A LOS COMPUESTOS DE 1,25-DIHIDROXI-16-ENO24-OXO-COLCALCIFEROL Y 1,24,25-TRIHIDROXI-16-ENO-COLECALCIFEROL QUE ESTIMULAN LA DIFERENCIACION DE LAS CELULAS HL-60, QUE LAS HACE UTILES COMO AGENTE PARA EL TRATAMIENTO DE ENFERMEDADES NEOPLASTICAS TAL COMO LA LEUCEMIA, Y TAMBIEN REDUCE LA PROLIFERACION DE QUERATINOCITOS HUMANOS HACIENDOLO UTILES COMO AGENTE PARA EL TRATAMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS DE LA PIEL COMO LA SORIASIS. SE PREPARAN POR PERFUSION DE 1,25-DIHIDROXI16-ENO-COLECALCIFEROL EN UNA POSICION DEL RIÑON, POR EXTRACCION DEL PERFUSATO Y EL AISLAMIENTO DE 1,25.-DIHIDROXI-16-ENO-24-OXOCOLECALCIFERO Y 1,24, 25-TRIHIDROXI-16-ENO-COLECALCIFEROL.
ES94114668T 1993-10-01 1994-09-17 Analogos de vitamina d3. Expired - Lifetime ES2113020T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/131,264 US5401733A (en) 1993-10-01 1993-10-01 Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol

Publications (1)

Publication Number Publication Date
ES2113020T3 true ES2113020T3 (es) 1998-04-16

Family

ID=22448675

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94114668T Expired - Lifetime ES2113020T3 (es) 1993-10-01 1994-09-17 Analogos de vitamina d3.

Country Status (15)

Country Link
US (1) US5401733A (es)
EP (1) EP0646576B1 (es)
JP (1) JP2677520B2 (es)
CN (1) CN1041201C (es)
AT (1) ATE162786T1 (es)
AU (1) AU683917B2 (es)
CA (1) CA2133144C (es)
DE (1) DE69408244T2 (es)
DK (1) DK0646576T3 (es)
ES (1) ES2113020T3 (es)
GR (1) GR3026154T3 (es)
NZ (1) NZ264537A (es)
PH (1) PH31439A (es)
RU (1) RU2133738C1 (es)
ZA (1) ZA947453B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9524812D0 (en) * 1995-12-05 1996-02-07 Leo Pharm Prod Ltd Chemical compounds
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
IL130484A (en) * 1996-12-20 2004-07-25 Chugai Pharmaceutical Co Ltd History of -16N-Vitamin-D
JPH10316652A (ja) * 1997-05-02 1998-12-02 Duphar Internatl Res Bv １６−デヒドロビタミンｄ化合物の製造方法
EP0981523B1 (en) 1997-05-16 2005-12-07 Woman & Infants Hospital Cyclic ether vitamin d3 compounds, 1alpha (oh) 3-epi-vitamin d3 compounds and uses thereof
ATE322477T1 (de) * 1997-05-16 2006-04-15 Woman & Infants Hospital 3-epi-vitamin d2 verbindungen und ihre anwendungen
AU9376998A (en) * 1997-09-02 1999-03-22 Johns Hopkins University School Of Medicine, The Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
US6331642B1 (en) * 1999-07-12 2001-12-18 Hoffmann-La Roche Inc. Vitamin D3 analogs
JP2004292314A (ja) * 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4617297A (en) * 1982-02-12 1986-10-14 Hoffmann-La Roche Inc. Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4501738A (en) * 1983-06-30 1985-02-26 Kureha Kagaku Kogyo Kabushiki Kaisha Pharmaceutical composition containing 24,25-dihydroxycholecalciferol as an active ingredient to treat pain, pyrexia or inflammatory diseases
US4495181A (en) * 1983-10-03 1985-01-22 The Regents Of The University Of California 1,25-Dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
JPS61129130A (ja) * 1984-11-27 1986-06-17 Kureha Chem Ind Co Ltd 抗尿毒症剤
US4612308A (en) * 1984-11-29 1986-09-16 Hoffmann-La Roche Inc. 25,26-Dehydro-1α,23(S,R)-dihydroxycholecalciferol and its epimers
JPS6253960A (ja) * 1985-05-30 1987-03-09 Taisho Pharmaceut Co Ltd ビタミンｄ↓３の誘導体
EP0245524B1 (en) * 1985-11-21 1991-04-17 Taisho Pharmaceutical Co. Ltd Vitamin d 3 derivative
JPS6391323A (ja) * 1986-10-03 1988-04-22 Kureha Chem Ind Co Ltd 抗尿路結石症剤
US5001118A (en) * 1986-12-29 1991-03-19 Kureha Kagaku Kogyo Kabushiki Kaisha Method for preventing senescence and increasing bone mass
US5145846A (en) * 1988-01-20 1992-09-08 Hoffmann-La Roche Inc. Vitamin D3 analogs
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US4851401A (en) * 1988-07-14 1989-07-25 Wisconsin Alumni Research Foundation Novel cyclopentano-vitamin D analogs
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
US5200536A (en) * 1992-02-10 1993-04-06 Daikin Industries Ltd. Fluorine-containing vitamin D3 analogues
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives

Also Published As

Publication number Publication date
ZA947453B (en) 1995-04-03
GR3026154T3 (en) 1998-05-29
JP2677520B2 (ja) 1997-11-17
AU7422594A (en) 1995-04-13
CN1041201C (zh) 1998-12-16
PH31439A (en) 1998-11-03
EP0646576A1 (en) 1995-04-05
CN1106384A (zh) 1995-08-09
EP0646576B1 (en) 1998-01-28
JPH07179418A (ja) 1995-07-18
AU683917B2 (en) 1997-11-27
NZ264537A (en) 1996-05-28
CA2133144A1 (en) 1995-04-02
DK0646576T3 (da) 1998-09-23
US5401733A (en) 1995-03-28
DE69408244D1 (de) 1998-03-05
RU94035663A (ru) 1996-07-20
CA2133144C (en) 2005-05-24
ATE162786T1 (de) 1998-02-15
RU2133738C1 (ru) 1999-07-27
DE69408244T2 (de) 1998-08-27

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