ES2106567T3 - 3-aril-4-alquil y 4,5-dialquil-4h-1,2,4-triazoles utiles como mejoradores de la memoria. - Google Patents

3-aril-4-alquil y 4,5-dialquil-4h-1,2,4-triazoles utiles como mejoradores de la memoria.

Info

Publication number
ES2106567T3
ES2106567T3 ES94930582T ES94930582T ES2106567T3 ES 2106567 T3 ES2106567 T3 ES 2106567T3 ES 94930582 T ES94930582 T ES 94930582T ES 94930582 T ES94930582 T ES 94930582T ES 2106567 T3 ES2106567 T3 ES 2106567T3
Authority
ES
Spain
Prior art keywords
sub
lower alkyl
dialquil
memory
alquil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94930582T
Other languages
English (en)
Inventor
Christopher R Dalton
John M Kane
Jerry A Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2106567T3 publication Critical patent/ES2106567T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A LA MEJORA DE LA MEMORIA Y DEL CONOCIMIENTO Y AL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER Y DEL SINDROME DE WERNICKE-KORSAKOFF MEDIANTE LA ADMINISTRACION DE 4ALQUIL-3-ARILO Y 4,5-DIALQUIL-4H-1,2,4-TRIAZOLAS DE LA FORMULA (I) EN LA QUE R1 Y R2 REPRESENTAN INDEPENDIENTEMENTE HIDROGENO, HALOGENO, TRIFLUORMETILO, NITRO, ALQUILO INFERIOR C{SUB,1-4} O ALCOXIDO INFERIOR C{SUB,1-4}, O JUNTAS, R1 Y R2 REPRESENTAN CH=CH-CH=CH, FORMANDO UN SISTEMA DE ANILLOS DE 1- O 2- NAFTILO; R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR C{SUB,1-4}; Y R4 REPRESENTA ALQUILO INFERIOR C{SUB,1-4}, BENCILO, O BENCILO SUSTITUIDO POR UNO O DOS GRUPOS SELECCIONADOS ENTRE HALOGENO, TRIFLUORMETIL, NITRO, ALQUILO INFERIOR C{SUB,1-4} O ALCOXIDO INFERIOR C{SUB,1-4}.
ES94930582T 1993-10-29 1994-10-04 3-aril-4-alquil y 4,5-dialquil-4h-1,2,4-triazoles utiles como mejoradores de la memoria. Expired - Lifetime ES2106567T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14637393A 1993-10-29 1993-10-29

Publications (1)

Publication Number Publication Date
ES2106567T3 true ES2106567T3 (es) 1997-11-01

Family

ID=22517085

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94930582T Expired - Lifetime ES2106567T3 (es) 1993-10-29 1994-10-04 3-aril-4-alquil y 4,5-dialquil-4h-1,2,4-triazoles utiles como mejoradores de la memoria.

Country Status (18)

Country Link
EP (1) EP0725776B1 (es)
JP (1) JP3779990B2 (es)
KR (1) KR100321885B1 (es)
CN (1) CN1046273C (es)
AT (1) ATE155462T1 (es)
AU (1) AU679130B2 (es)
CA (1) CA2175352C (es)
DE (1) DE69404322T2 (es)
DK (1) DK0725776T3 (es)
ES (1) ES2106567T3 (es)
FI (1) FI961793A0 (es)
GR (1) GR3024747T3 (es)
HU (1) HUT74693A (es)
IL (1) IL111404A (es)
NO (1) NO961719L (es)
NZ (1) NZ275620A (es)
WO (1) WO1995011887A1 (es)
ZA (1) ZA948352B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012138685A1 (en) 2011-04-04 2012-10-11 The Procter & Gamble Company Personal care article
WO2013025764A1 (en) 2011-08-15 2013-02-21 The Procter & Gamble Company Personal care articles having multi-zone compliant personal care compositions
CN104202987B (zh) 2011-08-15 2017-09-01 宝洁公司 个人护理方法
US9554978B2 (en) 2013-06-27 2017-01-31 The Procter & Gamble Company Personal care articles
EP3653611A1 (en) * 2018-11-15 2020-05-20 Centre National De La Recherche Scientifique Inhibitors of metallo-beta-lactamases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE541700C (de) * 1928-04-08 1932-01-15 C H Boehringer Sohn Akt Ges Verfahren zur Darstellung von 1,2,4-Triazolen
AR243171A1 (es) * 1985-10-29 1993-07-30 Merrell Pharma Inc Procedimiento para preparar 5-aril-2,4-dialquil-3h-1,2,4-triazol-3-tionas.
US5100906A (en) * 1990-04-19 1992-03-31 Merrell Dow Pharmaceuticals Inc. 5-aryl-4-alkyl-3h-1,2,4-triazole-3-thiones useful as memory enhancers
US5054050A (en) * 1990-04-30 1991-10-01 American Telephone & Telegraph Co. Drop testing in fiber to the home systems

Also Published As

Publication number Publication date
EP0725776A1 (en) 1996-08-14
HU9601114D0 (en) 1996-07-29
NZ275620A (en) 1999-01-28
DE69404322D1 (de) 1997-08-21
JP3779990B2 (ja) 2006-05-31
NO961719D0 (no) 1996-04-29
HUT74693A (en) 1997-01-28
NO961719L (no) 1996-04-29
CA2175352A1 (en) 1995-05-04
WO1995011887A1 (en) 1995-05-04
DE69404322T2 (de) 1997-10-30
FI961793L (fi) 1996-04-26
GR3024747T3 (en) 1997-12-31
EP0725776B1 (en) 1997-07-16
CN1134147A (zh) 1996-10-23
AU679130B2 (en) 1997-06-19
ATE155462T1 (de) 1997-08-15
ZA948352B (en) 1995-06-26
CA2175352C (en) 1999-03-02
DK0725776T3 (da) 1997-09-01
KR960705791A (ko) 1996-11-08
FI961793A7 (fi) 1996-04-26
JPH09504290A (ja) 1997-04-28
FI961793A0 (fi) 1996-04-26
IL111404A0 (en) 1994-12-29
AU7965494A (en) 1995-05-22
CN1046273C (zh) 1999-11-10
KR100321885B1 (ko) 2002-06-24
IL111404A (en) 2000-02-17

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