ES2100060T3 - Aminooxi-compuestos ciclicos inhibidores de ornitina descarboxilasa. - Google Patents

Aminooxi-compuestos ciclicos inhibidores de ornitina descarboxilasa.

Info

Publication number
ES2100060T3
ES2100060T3 ES94913516T ES94913516T ES2100060T3 ES 2100060 T3 ES2100060 T3 ES 2100060T3 ES 94913516 T ES94913516 T ES 94913516T ES 94913516 T ES94913516 T ES 94913516T ES 2100060 T3 ES2100060 T3 ES 2100060T3
Authority
ES
Spain
Prior art keywords
pct
aminooxi
decarboxylase inhibitors
cyclic compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913516T
Other languages
English (en)
Inventor
Jorg Frei
Jaroslav Stanek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2100060T3 publication Critical patent/ES2100060T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

COMPONENTES DE LA FORMULA (I): H2N-(CH2)N-A-(CH2)M-O-NH2 Y SUS SALES SON DESCRITOS EN EL QUE EL RADICAL A ES CICLOALQUILENO C3-C6; N ES 0 O 1 Y, INDEPENDIENTEMENTE DE ELLO, M ES 0 O1; CON LA PREVISION DE QUE A) LA DISTANCIA ENTRE EL RADICAL AMINOOXI H2N-O UE 4 ATOMOS DE CARBONO Y QUE B) LOS DOS RADICALES H2N-(CH2)NY (CH2)M-O-NH2 NO ESTAN UNIDOS AL MISMO ATOMO DE CARBONO DEL ANILLO DE A. LOS COMPONENTES DE LA FORMULA (I) Y SUS SALES SON INHIBIDORES DECARBOXILASA ORNITINA.
ES94913516T 1993-04-13 1994-04-02 Aminooxi-compuestos ciclicos inhibidores de ornitina descarboxilasa. Expired - Lifetime ES2100060T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH112893 1993-04-13

Publications (1)

Publication Number Publication Date
ES2100060T3 true ES2100060T3 (es) 1997-06-01

Family

ID=4203148

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913516T Expired - Lifetime ES2100060T3 (es) 1993-04-13 1994-04-02 Aminooxi-compuestos ciclicos inhibidores de ornitina descarboxilasa.

Country Status (18)

Country Link
US (1) US5516806A (es)
EP (1) EP0644872B1 (es)
JP (1) JPH07508045A (es)
CN (1) CN1034929C (es)
AT (1) ATE150448T1 (es)
AU (1) AU673736B2 (es)
CA (1) CA2135782A1 (es)
CZ (1) CZ7895A3 (es)
DE (1) DE69402142T2 (es)
DK (1) DK0644872T3 (es)
ES (1) ES2100060T3 (es)
GR (1) GR3023430T3 (es)
HU (1) HUT70522A (es)
NZ (1) NZ265252A (es)
PL (1) PL306764A1 (es)
RU (1) RU95110887A (es)
SK (1) SK3695A3 (es)
WO (1) WO1994024093A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07508046A (ja) * 1993-04-13 1995-09-07 ノバルティス　アクチェンゲゼルシャフト オルニチンデカルボキシラーゼを阻害する枝分れアミノオキシアミノアルカン誘導体
US6602862B1 (en) 2000-09-19 2003-08-05 Merz Pharma Gmbh & Co., Kgaa 1-Amino-alkylcyclohexanes as trypanocidal agents
CN100357262C (zh) * 2002-05-10 2007-12-26 中国农业大学 (E)－O－(烃基)－α－氧代环十二酮肟,其制备方法和作为杀真菌剂的用途
US7230002B2 (en) 2004-02-03 2007-06-12 Glenmark Pharmaceuticals Ltd. Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
WO2005075426A1 (en) * 2004-02-03 2005-08-18 Glenmark Pharmaceuticals Ltd. Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
JP5583592B2 (ja) * 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション Ｉｄｏ阻害剤
US20170268066A1 (en) * 2016-03-15 2017-09-21 Chalmers Ventures Ab Cancer biomarkers
CN109776502B (zh) * 2018-08-29 2021-06-08 湖北工业大学 一种含异吲哚二酮小分子抑制剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192110A (en) * 1962-04-24 1965-06-29 Colgate Palmolive Co Therapeutic aryl and thienyl hydroxylamines
US4390534A (en) * 1978-12-29 1983-06-28 Fujisawa Pharmaceutical Co., Ltd. Cephem and cepham compounds
FR2520194A1 (fr) * 1982-01-28 1983-07-29 Roussel Uclaf Application, comme facteur de croissance des vegetaux de la 4-nitrophenyl hydroxylamine
US4853467A (en) * 1987-05-19 1989-08-01 Bristol-Myers Company Nitrogen containing derivatives of epipodophyllotoxin glucosides
EP0369944A1 (de) * 1988-11-18 1990-05-23 Ciba-Geigy Ag Substituierte Oxadiaminobutane
DE3934208C2 (de) * 1989-10-13 1994-02-17 Kuesters Eduard Maschf Spulenkörper für die induktive Beheizung von Walzen
EP0495750A3 (en) * 1991-01-14 1992-09-16 Ciba-Geigy Ag Heterocyclic hydroxylamine
DE4105160A1 (de) * 1991-02-20 1992-08-27 Basf Ag Imino-substiuierte phenylderivate, ihre herstellung und diese enthaltende fungizide
JPH07508046A (ja) * 1993-04-13 1995-09-07 ノバルティス　アクチェンゲゼルシャフト オルニチンデカルボキシラーゼを阻害する枝分れアミノオキシアミノアルカン誘導体

Also Published As

Publication number Publication date
CN1104411A (zh) 1995-06-28
JPH07508045A (ja) 1995-09-07
ATE150448T1 (de) 1997-04-15
GR3023430T3 (en) 1997-08-29
PL306764A1 (en) 1995-04-18
AU673736B2 (en) 1996-11-21
RU95110887A (ru) 1996-10-27
HUT70522A (en) 1995-10-30
DK0644872T3 (da) 1997-10-06
AU6564594A (en) 1994-11-08
NZ265252A (en) 1996-09-25
DE69402142D1 (de) 1997-04-24
WO1994024093A1 (en) 1994-10-27
CA2135782A1 (en) 1994-10-27
EP0644872B1 (en) 1997-03-19
EP0644872A1 (en) 1995-03-29
SK3695A3 (en) 1995-07-11
US5516806A (en) 1996-05-14
CN1034929C (zh) 1997-05-21
CZ7895A3 (en) 1995-10-18
DE69402142T2 (de) 1997-11-27

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