NZ516133A - Alpha substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase - Google Patents
Alpha substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptaseInfo
- Publication number
- NZ516133A NZ516133A NZ516133A NZ51613398A NZ516133A NZ 516133 A NZ516133 A NZ 516133A NZ 516133 A NZ516133 A NZ 516133A NZ 51613398 A NZ51613398 A NZ 51613398A NZ 516133 A NZ516133 A NZ 516133A
- Authority
- NZ
- New Zealand
- Prior art keywords
- thioalkyl
- formula
- group
- inhibitors
- reverse transcriptase
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
6-thioalkyl pyrimidine-2-thioalkyl and alkylether compounds of Formula (I) are disclosed, wherein: M is 0 or 1, and R1 is selected from the group consisting of -CCH, -CO2R53, -CONR54R55, formula (II), formula (III) and formula (IV), and R12 is selected from the group consisting of -H, C1-C6 alkyl, -C3-C6 cycloalkyl, -CN, -C(O)NH2, -C(O)N(C1-C6alkyl)(C1-C6alkyl), -CO2H, -CO2(C1-C6alkyl), -CH2OH, -CH2NH2 or -CF3, and R13 is selected from the group consisting of -H, C1-C6 alkyl or -CF3, and Y is selected from -S, -S(O)-, -S(O)2, or -O-, and R4 is selected from the group consisting of -H, -OH, halo or -NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, -NH2 or R15 and R16 taken together with the -N form 1-pyrrolodino, 4-morpholino or 1-piperidino, and R5 is selected from the group consisting of -H, -C2H4OH, -C2H4-O-TBDMS, halo, -C3-C6 cycloalkyl, C1-C4 alkyl or C1-C3 alkoxy. The compounds of Formula (I) are useful in the treatment of individuals who are HIV positive.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5965697P | 1997-09-25 | 1997-09-25 | |
| NZ503586A NZ503586A (en) | 1997-09-25 | 1998-09-21 | Thioalkyl alpha substituted pyrimidine compounds for treating HIV. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ516133A true NZ516133A (en) | 2003-08-29 |
Family
ID=27767272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ516133A NZ516133A (en) | 1997-09-25 | 1998-09-21 | Alpha substituted pyrimidine-thioalkyl and alkylether compounds as inhibitors of viral reverse transcriptase |
Country Status (1)
| Country | Link |
|---|---|
| NZ (1) | NZ516133A (en) |
-
1998
- 1998-09-21 NZ NZ516133A patent/NZ516133A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed |