ES2099684B1 - Compuestos peptidicos con unidades de prolina y lisina, y procedimiento para preparar dichos compuestos y sus derivados de hidrogenacion. - Google Patents
Compuestos peptidicos con unidades de prolina y lisina, y procedimiento para preparar dichos compuestos y sus derivados de hidrogenacion.Info
- Publication number
- ES2099684B1 ES2099684B1 ES9600609A ES9600609A ES2099684B1 ES 2099684 B1 ES2099684 B1 ES 2099684B1 ES 9600609 A ES9600609 A ES 9600609A ES 9600609 A ES9600609 A ES 9600609A ES 2099684 B1 ES2099684 B1 ES 2099684B1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- procedure
- prolin
- preparing
- hydrogenation derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title abstract 4
- 238000005984 hydrogenation reaction Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- 108010007859 Lisinopril Proteins 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- -1 THEIR SALTS Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9500770A HU214581B (hu) | 1995-03-14 | 1995-03-14 | N2-(1S)-(1-/Etoxi-karbonil/-3-fenil-propil)-N6-(trifluor-acetil)-(L)-lizil-(L)-prolin-benzil-észter és eljárás előállítására |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2099684A1 ES2099684A1 (es) | 1997-05-16 |
| ES2099684B1 true ES2099684B1 (es) | 1998-02-16 |
Family
ID=10986628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9600609A Expired - Fee Related ES2099684B1 (es) | 1995-03-14 | 1996-03-13 | Compuestos peptidicos con unidades de prolina y lisina, y procedimiento para preparar dichos compuestos y sus derivados de hidrogenacion. |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP3699769B2 (de) |
| AT (1) | AT406372B (de) |
| DK (1) | DK175858B1 (de) |
| ES (1) | ES2099684B1 (de) |
| HU (2) | HU214579B (de) |
| PT (1) | PT101847B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2277446T3 (es) * | 1998-09-22 | 2007-07-01 | Kaneka Corporation | Proceso para la preparacion de n2-(1(s)-carboxi-3-fenilpropil)-l-lisil-l-prolina. |
| CN109422702B (zh) * | 2017-08-30 | 2023-04-18 | 上海科胜药物研发有限公司 | 赖诺普利中间体及其纯化方法 |
| CN109422797B (zh) * | 2017-08-30 | 2023-12-19 | 上海科胜药物研发有限公司 | 一种赖诺普利中间体的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1277993C (en) * | 1986-03-27 | 1990-12-18 | Kazuhiko Yamada | N2-(1-carboxy-3-oxo-3-phenylpropyl)-l-lysine compounds and their derivatives |
| JPH01254651A (ja) * | 1988-04-04 | 1989-10-11 | Kanegafuchi Chem Ind Co Ltd | Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法 |
-
1995
- 1995-03-14 HU HU9702176A patent/HU214579B/hu unknown
- 1995-03-14 HU HU9500770A patent/HU214581B/hu unknown
-
1996
- 1996-03-08 PT PT10184796A patent/PT101847B/pt not_active IP Right Cessation
- 1996-03-11 AT AT45796A patent/AT406372B/de not_active IP Right Cessation
- 1996-03-12 DK DK28696A patent/DK175858B1/da not_active IP Right Cessation
- 1996-03-13 ES ES9600609A patent/ES2099684B1/es not_active Expired - Fee Related
- 1996-03-14 JP JP05733896A patent/JP3699769B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HU9702176D0 (en) | 1998-01-28 |
| HUT75716A (en) | 1997-05-28 |
| JP3699769B2 (ja) | 2005-09-28 |
| ES2099684A1 (es) | 1997-05-16 |
| PT101847A (pt) | 1996-09-30 |
| ATA45796A (de) | 1999-09-15 |
| HU214581B (hu) | 1998-04-28 |
| PT101847B (pt) | 1998-04-30 |
| DK28696A (da) | 1996-09-15 |
| HU9500770D0 (en) | 1995-05-29 |
| AT406372B (de) | 2000-04-25 |
| DK175858B1 (da) | 2005-04-11 |
| JPH08253497A (ja) | 1996-10-01 |
| HU214579B (hu) | 1998-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19970516 Kind code of ref document: A1 Effective date: 19970516 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20180807 |