ES2099684B1 - PEPTIDE COMPOUNDS WITH PROLIN AND LYSINE UNITS, AND PROCEDURE FOR PREPARING SUCH COMPOUNDS AND THEIR HYDROGENATION DERIVATIVES. - Google Patents

PEPTIDE COMPOUNDS WITH PROLIN AND LYSINE UNITS, AND PROCEDURE FOR PREPARING SUCH COMPOUNDS AND THEIR HYDROGENATION DERIVATIVES.

Info

Publication number
ES2099684B1
ES2099684B1 ES9600609A ES9600609A ES2099684B1 ES 2099684 B1 ES2099684 B1 ES 2099684B1 ES 9600609 A ES9600609 A ES 9600609A ES 9600609 A ES9600609 A ES 9600609A ES 2099684 B1 ES2099684 B1 ES 2099684B1
Authority
ES
Spain
Prior art keywords
compounds
procedure
prolin
preparing
hydrogenation derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9600609A
Other languages
Spanish (es)
Other versions
ES2099684A1 (en
Inventor
Janos Dr Fischer
Tamas Dr Fodor
Laszlo Dobay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES2099684A1 publication Critical patent/ES2099684A1/en
Application granted granted Critical
Publication of ES2099684B1 publication Critical patent/ES2099684B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

COMPUESTOS PEPTIDICOS CON UNIDADES DE PROLINA Y LISINA, Y PROCEDIMIENTOS PARA PREPARAR DICHOS COMPUESTOS Y SUS DERIVADOS DE HIDROGENACION. LOS COMPUESTOS PEPTIDICOS, INCLUYENDO SUS SALES, SON DE LA FORMULA: FORMULA EL PROCEDIMIENTO PARA PREPARARLOS COMPRENDE HACER REACCIONAR HIDROCLORURO DE (L)-PROLINATO DE BENCILO O UNA SAL DEL MISMO CON N2-(1S)-(1-ETOXICARBONIL-3-FENILPROPIL)-N6-TRIFLUOROACETIL-(L)-LISINA O SU N-CARBOXI-ANHIDRIDO. SI SE DESEA, EL PRODUCTO OBTENIDO SE PUEDE TRANSFORMAR EN UNA DE SUS SALES. EL PROCEDIMIENTO PARA PREPARAR DERIVADOS DE HIDROGENACION DE DICHOS COMPUESTOS DE FORMULA (II) COMPRENDE HIDROGENAR CATALITICAMENTE LOS MISMOS O UNA DE SUS SALES. LOS DERIVADOS DE HIDROGENACION OBTENIDOS PUEDEN UTILIZARSE PARA PREPARAR LISINOPRIL, QUE ES UN PRODUCTO INHIBIDOR DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA.PEPTIDE COMPOUNDS WITH PROLIN AND LYSINE UNITS, AND PROCEDURES FOR PREPARING SUCH COMPOUNDS AND THEIR HYDROGENATION DERIVATIVES. PEPTIDIC COMPOUNDS, INCLUDING THEIR SALTS, ARE OF THE FORMULA: FORMULATES THE PROCEDURE TO PREPARE THEM INCLUDES REACTION OF (L) -PROLINATE OF BENZYL OR A SALT OF THE SAME WITH N2- (1S-EIL-3) ) -N6-TRIFLUOROACETIL- (L) -LYSINE OR ITS N-CARBOXY-ANHYDRIDE. IF DESIRED, THE PRODUCT OBTAINED CAN BE TRANSFORMED INTO ONE OF ITS SALTS. THE PROCEDURE TO PREPARE HYDROGENATION DERIVATIVES OF SUCH COMPOUNDS OF FORMULA (II) INCLUDES CATALYTICALLY HYDROGENING THE SAME OR ONE OF ITS SALTS. THE HYDROGENATION DERIVATIVES OBTAINED MAY BE USED TO PREPARE LYSINOPRIL, WHICH IS AN ANGIOTENSIN CONVERTING ENZYME INHIBITING PRODUCT.

ES9600609A 1995-03-14 1996-03-13 PEPTIDE COMPOUNDS WITH PROLIN AND LYSINE UNITS, AND PROCEDURE FOR PREPARING SUCH COMPOUNDS AND THEIR HYDROGENATION DERIVATIVES. Expired - Fee Related ES2099684B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9500770A HU214581B (en) 1995-03-14 1995-03-14 N2-(1s)-(1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoro-acetyl-l-lysyl-l-proline-benzilester and process for producing it

Publications (2)

Publication Number Publication Date
ES2099684A1 ES2099684A1 (en) 1997-05-16
ES2099684B1 true ES2099684B1 (en) 1998-02-16

Family

ID=10986628

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9600609A Expired - Fee Related ES2099684B1 (en) 1995-03-14 1996-03-13 PEPTIDE COMPOUNDS WITH PROLIN AND LYSINE UNITS, AND PROCEDURE FOR PREPARING SUCH COMPOUNDS AND THEIR HYDROGENATION DERIVATIVES.

Country Status (6)

Country Link
JP (1) JP3699769B2 (en)
AT (1) AT406372B (en)
DK (1) DK175858B1 (en)
ES (1) ES2099684B1 (en)
HU (2) HU214581B (en)
PT (1) PT101847B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1035131B1 (en) * 1998-09-22 2006-11-22 Kaneka Corporation Process for the preparation of n2 -(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-proline
CN109422797B (en) * 2017-08-30 2023-12-19 上海科胜药物研发有限公司 Preparation method of lisinopril intermediate
CN109422702B (en) * 2017-08-30 2023-04-18 上海科胜药物研发有限公司 Lisinopril intermediate and purification method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2028812T3 (en) * 1986-03-27 1992-07-16 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF N2- (1-CARBOXI-3-OXO-3-FENILPROPIL) -L-LYSINE.
JPH01254651A (en) * 1988-04-04 1989-10-11 Kanegafuchi Chem Ind Co Ltd N2-(1-carboxy-3-phenylpropyl)-l-lysin derivative and production of lysinopuryl using said compound

Also Published As

Publication number Publication date
HU214579B (en) 1998-04-28
HU214581B (en) 1998-04-28
HUT75716A (en) 1997-05-28
JP3699769B2 (en) 2005-09-28
HU9702176D0 (en) 1998-01-28
ATA45796A (en) 1999-09-15
PT101847A (en) 1996-09-30
JPH08253497A (en) 1996-10-01
DK28696A (en) 1996-09-15
AT406372B (en) 2000-04-25
HU9500770D0 (en) 1995-05-29
DK175858B1 (en) 2005-04-11
ES2099684A1 (en) 1997-05-16
PT101847B (en) 1998-04-30

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