ES2099156T3 - Particulas de polimero fluorescentes magneticamente sensibles y aplicacion de las mismas. - Google Patents

Particulas de polimero fluorescentes magneticamente sensibles y aplicacion de las mismas.

Info

Publication number
ES2099156T3
ES2099156T3 ES91902535T ES91902535T ES2099156T3 ES 2099156 T3 ES2099156 T3 ES 2099156T3 ES 91902535 T ES91902535 T ES 91902535T ES 91902535 T ES91902535 T ES 91902535T ES 2099156 T3 ES2099156 T3 ES 2099156T3
Authority
ES
Spain
Prior art keywords
magnetically responsive
polymer particles
particles
fluorescent polymer
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91902535T
Other languages
English (en)
Inventor
Chao-Huei J Wang
Dinesh O Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade International Inc
Original Assignee
Dade International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/452,099 external-priority patent/US5283079A/en
Application filed by Dade International Inc filed Critical Dade International Inc
Application granted granted Critical
Publication of ES2099156T3 publication Critical patent/ES2099156T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/10—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure
    • H01F1/11—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles
    • H01F1/111—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles with a non-magnetic core
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F257/00—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00
    • C08F257/02—Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group C08F12/00 on to polymers of styrene or alkyl-substituted styrenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F285/00—Macromolecular compounds obtained by polymerising monomers on to preformed graft polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/10—Magnetic particle immunoreagent carriers the magnetic material being used to coat a pre-existing polymer particle but not being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/40—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the monomer composition prior to polymerisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
    • G01N2446/86—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids the coating being pre-functionalised for attaching immunoreagents, e.g. aminodextran

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Power Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polymerisation Methods In General (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)

Abstract

ESTA INVENCION PROPORCIONA UN NUEVO PROCESO PARA PRODUCIR PARTICULAS DE POLIMERO FLUORESCENTE SENSIBLE MAGNETICAMENTE QUE CONTIENEN PARTICULAS DE NUCLEO POLIMERICO REVESTIDAS UNIFORMEMENTE CON UNA CAPA DE POLIMERO QUE CONTIENE OXIDO DE METAL SENSIBLE MAGNETICAMENTE. UNA AMPLIA VARIEDAD DE PARTICULAS POLIMERICAS CON TAMAÑOS QUE OSCILAN ENTRE 1 Y 100 MICRAS PUEDEN UTILIZARSE COMO PARTICULAS NUCLEO Y TRANSFORMARSE EN PARTICULAS DE POLIMERO SENSIBLES MAGNETICAMENTE. LA SUPERFICIE DE ESTAS PARTICULAS DE POLIMERO SENSIBLE MAGNETICAMENTE PUEDEN REVESTIRSE ADEMAS CON OTRA CAPA DE POLIMERO FUNCIONALIZADO. ESTAS PARTICULAS DE POLIMERO FLUORESCENTE SENSIBLE MAGNETICAMENTE PUEDEN UTILIZARSE PARA EL ACOPLAMIENTO PASIVO O COVALENTE DE MATERIAL BIOLOGICO COMO ANTIGENOS, ANTICUERPOS, ENZIMAS O HIBRIDACION DE ADN/ARN Y SON USADOS COMO FASE SOLIDA PARA VARIOS TIPOS DE PRUEBAS INMUNOLOGICAS, ENSAYOS DE MUESTRAS DE HIBRIDACION ADN/ARN, PURIFICACION DE AFINIDAD, SEPARACION DE CELULA, Y OTRAS APLICACIONES MEDICAS, DIAGNOSTICAS E INDUSTRIALES.
ES91902535T 1989-12-14 1990-12-12 Particulas de polimero fluorescentes magneticamente sensibles y aplicacion de las mismas. Expired - Lifetime ES2099156T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45148389A 1989-12-14 1989-12-14
US45127489A 1989-12-14 1989-12-14
US45149489A 1989-12-14 1989-12-14
US07/452,099 US5283079A (en) 1987-10-26 1989-12-14 Process to make magnetically responsive fluorescent polymer particles

Publications (1)

Publication Number Publication Date
ES2099156T3 true ES2099156T3 (es) 1997-05-16

Family

ID=27503985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91902535T Expired - Lifetime ES2099156T3 (es) 1989-12-14 1990-12-12 Particulas de polimero fluorescentes magneticamente sensibles y aplicacion de las mismas.

Country Status (9)

Country Link
EP (1) EP0463144B1 (es)
JP (2) JP2589618B2 (es)
AT (1) ATE148746T1 (es)
AU (1) AU634631B2 (es)
CA (1) CA2046894C (es)
DE (1) DE69029908T2 (es)
DK (1) DK0463144T3 (es)
ES (1) ES2099156T3 (es)
WO (1) WO1991009141A1 (es)

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FI915731A0 (fi) * 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
GB9314394D0 (en) * 1993-07-12 1993-08-25 Slater James H A security device using an ultrasensitive microtrace for protecting materials,articles and items
US5656429A (en) * 1994-10-03 1997-08-12 Adelman; Lonnie W. Polynucleotide and protein analysis method using magnetizable moieties
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
FR2749082B1 (fr) * 1996-05-24 1998-06-26 Bio Merieux Particules superparamagnetiques et monodispersees
WO2000005357A1 (fr) * 1998-07-22 2000-02-03 Japan As Represented By Director-General Of Agency Of Industrial Science And Technology Complexe marque, et ses procedes de production et d'utilisation
AU4989501A (en) 2000-04-06 2001-10-23 Luminex Corp Magnetically-responsive microspheres
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
WO2001098765A1 (en) 2000-06-21 2001-12-27 Bioarray Solutions, Ltd. Multianalyte molecular analysis
EP1239284A1 (en) * 2001-03-08 2002-09-11 The Technology Partnership Public Limited Company Non-separation assay method and system using opaque particles
DE10125258A1 (de) 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
FR2841156B1 (fr) * 2002-06-19 2004-09-10 Bio Merieux Nouvelles particules magnetiques fluorescentes,ainsi que les conjugues de telles particules et les compositions diagnostiques , therapeutiques ou prophylactiques les contenant
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
GB0228914D0 (en) * 2002-12-11 2003-01-15 Dynal Biotech Asa Particles
WO2004092732A1 (ja) 2003-04-16 2004-10-28 Sekisui Chemical Co., Ltd. 磁性体内包粒子及びその製造方法、免疫測定用粒子、並びに、免疫測定法
CN1312479C (zh) * 2003-08-08 2007-04-25 清华大学 一种纳米荧光磁粒及其制备方法
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
JP4549837B2 (ja) * 2004-12-17 2010-09-22 俊一 内山 酵素免疫測定材料の製造方法
CN100541677C (zh) * 2005-01-20 2009-09-16 卢米尼克斯股份有限公司 用于基于荧光应用的磁性微球
JP5147039B2 (ja) * 2006-05-17 2013-02-20 国立大学法人山口大学 樹脂粒子およびその製造方法
CA2653761C (en) 2006-06-02 2014-07-29 Luminex Corporation Systems and methods for performing measurements of one or more materials
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
EP1903337B1 (en) * 2006-09-20 2015-07-22 Mycartis N.V. Coating for microcarriers
JP5277540B2 (ja) * 2007-01-09 2013-08-28 富士ゼロックス株式会社 磁性重合体粒子及びその製造方法、並びに、水分散体、カートリッジ及び画像形成装置
WO2011127390A2 (en) 2010-04-09 2011-10-13 Luminex Corporation Magnetic separation device
EP2577276A4 (en) * 2010-06-04 2017-01-25 Michael Himmelhaus Optical cavity mode excitations in magnetic fluorescent microparticles
US9597418B2 (en) * 2014-03-18 2017-03-21 Universite De Nantes Magnetic and fluorescent reverse nanoassemblies

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Also Published As

Publication number Publication date
ATE148746T1 (de) 1997-02-15
DK0463144T3 (da) 1997-03-10
EP0463144B1 (en) 1997-02-05
JPH0928397A (ja) 1997-02-04
AU634631B2 (en) 1993-02-25
CA2046894A1 (en) 1991-06-15
JP2589618B2 (ja) 1997-03-12
DE69029908T2 (de) 1997-05-22
EP0463144A4 (en) 1992-12-09
AU7174691A (en) 1991-07-18
DE69029908D1 (de) 1997-03-20
CA2046894C (en) 1999-10-19
JP2762259B2 (ja) 1998-06-04
EP0463144A1 (en) 1992-01-02
WO1991009141A1 (en) 1991-06-27
JPH04503968A (ja) 1992-07-16

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