ATE74797T1 - Material zur fixierung biologischer substanzen und seine verwendung, insbesondere als traeger fuer die affinitaetschromatographie. - Google Patents
Material zur fixierung biologischer substanzen und seine verwendung, insbesondere als traeger fuer die affinitaetschromatographie.Info
- Publication number
- ATE74797T1 ATE74797T1 AT89402165T AT89402165T ATE74797T1 AT E74797 T1 ATE74797 T1 AT E74797T1 AT 89402165 T AT89402165 T AT 89402165T AT 89402165 T AT89402165 T AT 89402165T AT E74797 T1 ATE74797 T1 AT E74797T1
- Authority
- AT
- Austria
- Prior art keywords
- factors
- activated
- support
- charges
- hydrophilic polymer
- Prior art date
Links
- 239000000463 material Substances 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 238000001042 affinity chromatography Methods 0.000 title 1
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 3
- 238000000926 separation method Methods 0.000 abstract 2
- 102000004411 Antithrombin III Human genes 0.000 abstract 1
- 108090000935 Antithrombin III Proteins 0.000 abstract 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 229960005348 antithrombin iii Drugs 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 238000012412 chemical coupling Methods 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 230000002427 irreversible effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
- B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
- B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
- B01J20/267—Cross-linked polymers
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- B01J20/28004—Sorbent size or size distribution, e.g. particle size
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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- B01J20/28057—Surface area, e.g. B.E.T specific surface area
- B01J20/28061—Surface area, e.g. B.E.T specific surface area being in the range 100-500 m2/g
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- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
- B01J20/28069—Pore volume, e.g. total pore volume, mesopore volume, micropore volume
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- B01J20/28078—Pore diameter
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- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
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- B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
- B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/3092—Packing of a container, e.g. packing a cartridge or column
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
- B01J20/3204—Inorganic carriers, supports or substrates
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- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
- B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
- B01J20/3221—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond the chemical bond being an ionic interaction
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- B01J20/3268—Macromolecular compounds
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- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
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- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3289—Coatings involving more than one layer of same or different nature
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- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
- B01J2220/4812—Sorbents characterised by the starting material used for their preparation the starting material being of organic character
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- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
- B01J2220/4812—Sorbents characterised by the starting material used for their preparation the starting material being of organic character
- B01J2220/4843—Algae, aquatic plants or sea vegetals, e.g. seeweeds, eelgrass
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
- Y10S530/814—Cellulose or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8810435A FR2635019B1 (fr) | 1988-08-02 | 1988-08-02 | Materiau capable de fixer les substances biologiques, et ses applications notamment comme support de chromatographie d'affinite |
EP89402165A EP0357479B1 (de) | 1988-08-02 | 1989-07-28 | Material zur Fixierung biologischer Substanzen und seine Verwendung, insbesondere als Träger für die Affinitätschromatographie |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE74797T1 true ATE74797T1 (de) | 1992-05-15 |
Family
ID=9369033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89402165T ATE74797T1 (de) | 1988-08-02 | 1989-07-28 | Material zur fixierung biologischer substanzen und seine verwendung, insbesondere als traeger fuer die affinitaetschromatographie. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5372820A (de) |
EP (1) | EP0357479B1 (de) |
JP (1) | JPH0290943A (de) |
AT (1) | ATE74797T1 (de) |
DE (1) | DE68901233D1 (de) |
ES (1) | ES2030989T3 (de) |
FR (1) | FR2635019B1 (de) |
GR (1) | GR3004807T3 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5652059A (en) * | 1991-11-20 | 1997-07-29 | Bar Ilan University | Method for attaching microspheres to a substrate |
IL100105A (en) * | 1991-11-20 | 1996-01-19 | Univ Bar Ilan | Supported microspheres |
JP3112682B2 (ja) * | 1992-06-19 | 2000-11-27 | セプラコア インコーポレーテッド | 表面処理および安定化した多孔質支持体,その製造法ならびに使用法 |
US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US6491965B1 (en) | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
US7045585B2 (en) | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
WO1997032010A1 (fr) * | 1996-02-29 | 1997-09-04 | Takara Shuzo Co., Ltd. | Procede pour la purification et l'elimination de virus |
US5756870A (en) * | 1996-05-03 | 1998-05-26 | Betzdearborn Inc. | Methods for inhibiting the polymerization of ethylenically unsaturated monomers |
US5789467A (en) * | 1996-06-28 | 1998-08-04 | W. R. Grace & Co.-Conn. | Crosslinked tannin/inorganic oxide composites |
US6177282B1 (en) * | 1997-08-12 | 2001-01-23 | Mcintyre John A. | Antigens embedded in thermoplastic |
CA2317495C (en) | 1998-01-12 | 2004-11-09 | F. William Collins | A process for the isolation, recovery and purification of non-polar extractives |
US20020104801A1 (en) * | 1998-04-06 | 2002-08-08 | Nicolas Voute | Small dense microporous solid support materials, their preparation,and use for purification of large macromolecules and bioparticles |
WO2003014736A1 (en) * | 2001-08-10 | 2003-02-20 | Meditech Reserach Limited | Biological molecules comprising glycosaminoglycans |
JP2004298783A (ja) * | 2003-03-31 | 2004-10-28 | Kitakyushu Foundation For The Advancement Of Industry Science & Technology | 化学物質分離膜及びその製造方法、並びに化学物質の検出方法及び化学物質検出装置 |
JPWO2005085835A1 (ja) * | 2004-03-04 | 2008-01-24 | ダイセル化学工業株式会社 | 光学異性体用分離剤 |
WO2006022822A1 (en) * | 2004-08-10 | 2006-03-02 | Prime Separations, Incorporated | Chromatographic separation member and method |
FR2914305B1 (fr) * | 2007-03-29 | 2009-07-03 | Proteins & Peptides Man | Dextran fonctionnalise par des amino-acides hydrophobes. |
GB2473814B (en) | 2009-09-16 | 2014-06-11 | Spheritech Ltd | Hollow particulate support |
KR102196230B1 (ko) | 2012-09-17 | 2020-12-29 | 더블유.알. 그레이스 앤드 캄파니-콘. | 크로마토그래피 매질 및 장치 |
US11389783B2 (en) | 2014-05-02 | 2022-07-19 | W.R. Grace & Co.-Conn. | Functionalized support material and methods of making and using functionalized support material |
SG10201911134QA (en) | 2015-06-05 | 2020-01-30 | Grace W R & Co | Adsorbent bioprocessing clarification agents and methods of making and using the same |
CN107629142A (zh) * | 2017-09-20 | 2018-01-26 | 常州药物研究所有限公司 | 修饰的交联葡聚糖微球及其制备方法以及含此微球的医用组合物 |
CN111818981B (zh) * | 2018-03-05 | 2022-07-05 | 欧洲手性技术股份公司 | 用于生物分离的复合材料 |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3645939A (en) * | 1968-02-01 | 1972-02-29 | Us Plywood Champ Papers Inc | Compatibilization of hydroxyl containing materials and thermoplastic polymers |
US3896217A (en) * | 1973-03-19 | 1975-07-22 | Summa Corp | Method and apparatus for radioimmunoassay with regeneration of immunoadsorbent |
US4335017A (en) * | 1975-12-15 | 1982-06-15 | United Kingdom Atomic Energy Authority | Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography |
FR2403098A1 (fr) * | 1977-09-19 | 1979-04-13 | Merieux Inst | Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application |
FR2548193B1 (fr) * | 1983-06-29 | 1985-10-18 | Commissariat Energie Atomique | Produit constitue par un polymere ou un copolymere comportant dans sa chaine des groupes presentant une affinite vis-a-vis de la thrombine, son procede de preparation et son utilisation pour la separation et la purification de la thrombine |
US4933284A (en) * | 1986-05-07 | 1990-06-12 | Uop | Regenerable dialkylaminoalkyl cellulose support matrix for immobilizing biologically active materials |
US4933285A (en) * | 1986-10-07 | 1990-06-12 | Environmental Technologies Group, Inc. | Multiple monolayers of polymeric linkages on a solid phase for immobilizing macromolecules |
US5077210A (en) * | 1989-01-13 | 1991-12-31 | Eigler Frances S | Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent |
-
1988
- 1988-08-02 FR FR8810435A patent/FR2635019B1/fr not_active Expired - Fee Related
-
1989
- 1989-07-28 ES ES198989402165T patent/ES2030989T3/es not_active Expired - Lifetime
- 1989-07-28 EP EP89402165A patent/EP0357479B1/de not_active Expired - Lifetime
- 1989-07-28 AT AT89402165T patent/ATE74797T1/de not_active IP Right Cessation
- 1989-07-28 DE DE8989402165T patent/DE68901233D1/de not_active Expired - Fee Related
- 1989-08-02 JP JP1201136A patent/JPH0290943A/ja active Pending
-
1992
- 1992-06-04 GR GR920401150T patent/GR3004807T3/el unknown
- 1992-10-14 US US07/961,033 patent/US5372820A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5372820A (en) | 1994-12-13 |
EP0357479B1 (de) | 1992-04-15 |
EP0357479A1 (de) | 1990-03-07 |
DE68901233D1 (de) | 1992-05-21 |
FR2635019A1 (fr) | 1990-02-09 |
GR3004807T3 (de) | 1993-04-28 |
ES2030989T3 (es) | 1992-11-16 |
JPH0290943A (ja) | 1990-03-30 |
FR2635019B1 (fr) | 1992-06-12 |
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