DE69842166D1 - Zusammensetzung und verfahren zur regulierung der adhäsion von zellen und biomolekülen an hydrophobe oberflächen - Google Patents

Zusammensetzung und verfahren zur regulierung der adhäsion von zellen und biomolekülen an hydrophobe oberflächen

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Publication number
DE69842166D1
DE69842166D1 DE69842166T DE69842166T DE69842166D1 DE 69842166 D1 DE69842166 D1 DE 69842166D1 DE 69842166 T DE69842166 T DE 69842166T DE 69842166 T DE69842166 T DE 69842166T DE 69842166 D1 DE69842166 D1 DE 69842166D1
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Prior art keywords
composition
adhesion
biomolecules
regulating
cells
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Expired - Lifetime
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DE69842166T
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English (en)
Inventor
Patrick A Tresco
Karin D Caldwell
Jennifer Neff
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University of Utah Research Foundation UURF
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University of Utah Research Foundation UURF
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/02—Compounds containing any of the groups, e.g. carbazates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
DE69842166T 1997-01-15 1998-01-15 Zusammensetzung und verfahren zur regulierung der adhäsion von zellen und biomolekülen an hydrophobe oberflächen Expired - Lifetime DE69842166D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/784,203 US6284503B1 (en) 1993-08-20 1997-01-15 Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
PCT/US1998/000337 WO1998031734A1 (en) 1997-01-15 1998-01-15 Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces

Publications (1)

Publication Number Publication Date
DE69842166D1 true DE69842166D1 (de) 2011-04-21

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DE69842166T Expired - Lifetime DE69842166D1 (de) 1997-01-15 1998-01-15 Zusammensetzung und verfahren zur regulierung der adhäsion von zellen und biomolekülen an hydrophobe oberflächen

Country Status (10)

Country Link
US (3) US6284503B1 (de)
EP (1) EP1002066B1 (de)
JP (1) JP2001512565A (de)
KR (1) KR20000070229A (de)
AT (1) ATE501249T1 (de)
AU (1) AU740877B2 (de)
CA (1) CA2277995C (de)
DE (1) DE69842166D1 (de)
IL (2) IL130961A0 (de)
WO (1) WO1998031734A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284503B1 (en) 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
ES2353840T3 (es) * 1997-04-21 2011-03-07 California Institute Of Technology Recubrimientos tisulares poliméricos multifuncionales.
DE19748489A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
AR021240A1 (es) * 1998-11-13 2002-07-03 Commw Scient Ind Res Org Peptidos acoplados
AU769571B2 (en) * 1999-04-28 2004-01-29 Universitat Zurich Polyionic coatings in analytic and sensor devices
JP2001083162A (ja) * 1999-09-17 2001-03-30 Fuji Photo Film Co Ltd 膜状生体高分子吸着材及び吸着用キット
US7220276B1 (en) * 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
WO2002030818A2 (en) * 2000-10-13 2002-04-18 University Of Cincinnati Methods for synthesizing precipitated silica and use thereof
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DE10100961B4 (de) 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
AU2002305924A1 (en) 2001-02-02 2002-10-08 Allvivo, Inc. End group activated polymers with oligonucleotide ligands
US20050244843A1 (en) * 2001-11-16 2005-11-03 Wen-Tien Chen Blood test prototypes and methods for the detection of circulating tumor and endothelial cells
US20030148017A1 (en) * 2001-12-07 2003-08-07 Olli Tuominen Copolymer coating for a hydrophobic membrane
AU2002328824A1 (en) * 2002-06-29 2004-01-19 Aquanova German Solubilisate Technologies (Agt) Gmbh Isoflavone concentrate and method for production thereof
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7598224B2 (en) * 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US20050059140A1 (en) * 2003-09-12 2005-03-17 Andrea Liebmann-Vinson Methods of surface modification to enhance cell adhesion
DE10358565B4 (de) * 2003-12-15 2007-06-28 P.A.L.M. Microlaser Technologies Ag Aufnahmeelement zum Aufnehmen eines aus einer biologischen Masse mittels Laserstrahlung herausgelösten Objekts und Verfahren zur Gewinnung und Verarbeitung eines biologischen Objekts
US7414028B1 (en) 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
CA2555583A1 (en) 2004-02-20 2005-09-09 Biosurface Engineering Technologies, Inc. Positive modulator of bone morphogenic protein-2
WO2006086617A2 (en) * 2005-02-10 2006-08-17 Emory University Polyethylene oxide polymers including anti-inflammatory glycodendrons
EP1712284B1 (de) * 2005-04-15 2012-10-10 Samsung Electronics Co., Ltd. Methode zur Zelltrennung mit Benutzung hydrophober fester Träger
US7749701B2 (en) * 2005-08-11 2010-07-06 Agilent Technologies, Inc. Controlling use of oligonucleotide sequences released from arrays
DE102005040211B4 (de) * 2005-08-16 2010-02-11 Maquet Cardiopulmonary Ag Verwendung von nichtionischen Estern in einer Beschichtung für mit Blut in Kontakt kommende Oberflächen und medizinische Vorrichtung
US20070225795A1 (en) * 2006-03-24 2007-09-27 Juan Granada Composite vascular prosthesis
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
EP2046350A4 (de) 2006-06-22 2011-09-14 Biosurface Eng Tech Inc Zusammensetzungen und verfahren zur freisetzung eines bmp-2-amplifikators/coaktivators für verstärkte osteogenese
EP2069790B1 (de) * 2006-11-01 2015-04-29 Beckman Coulter, Inc. Bindungsoberflächen für affinitätstests
US20080187188A1 (en) * 2007-02-07 2008-08-07 Oleg Beletski Systems, apparatuses and methods for facilitating efficient recognition of delivered content
DK2497505T3 (en) * 2007-04-16 2016-12-05 Regentis Biomaterials Ltd Compositions and methods of the cage-forming
US8529897B2 (en) * 2007-08-16 2013-09-10 Carnegie Mellon University Inflammation-regulating compositions and methods
DK2247716T3 (da) 2008-01-30 2012-05-29 Geron Corp Syntetiske overflader til dyrkning af celler i kemisk defineret medie
KR101635750B1 (ko) 2008-01-30 2016-07-04 아스테리아스 바이오세라퓨틱스, 인크. 줄기 세포 유래 올리고덴드로사이트 전구 세포를 배양하기 위한 합성 표면
SG188098A1 (en) 2008-01-30 2013-03-28 Geron Corp Synthetic surfaces for culturing stem cell derived cardiomyocytes
US8329469B2 (en) 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
DE102008027133A1 (de) 2008-05-30 2009-12-03 Ls Medcap Gmbh Vollsynthetisches Albumin-Analogon
WO2010036257A1 (en) * 2008-09-25 2010-04-01 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2010115243A1 (en) * 2009-04-09 2010-10-14 The University Of Queensland Block copolymer blends
DE102009040880B4 (de) * 2009-09-09 2012-10-18 Andreas Hettich Gmbh & Co. Kg Vorrichtung zur Durchführung von Tests zur Hämostase
WO2011063152A1 (en) * 2009-11-18 2011-05-26 Affinergy, Inc. Methods and compositions for soft tissue repair
EP2761293B1 (de) * 2011-09-30 2022-04-06 Wake Forest University Health Sciences Biogerüste zur bildung von motorendplatten und anderen spezialisierten gewebestrukturen
EP3474914A4 (de) * 2016-06-27 2020-01-15 University Of Louisville Research Foundation, Inc. Kügelchen mit biologisch relevanten materialien sowie entsprechende verfahren
US10269569B2 (en) * 2016-11-29 2019-04-23 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device and methods of manufacture
JP7192314B2 (ja) * 2017-08-31 2022-12-20 東洋インキＳｃホールディングス株式会社 蛋白質、細胞又は微生物の接着抑制剤、並びにその用途
US10941274B1 (en) 2020-09-01 2021-03-09 King Abdulaziz University Nanoparticle-infused ABS filament for 3D-printed materials and uses for neutron detection and discrimination

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264766A (en) 1877-09-19 1981-04-28 Hoffmann-La Roche Inc. Immunological diagnostic reagents
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
SE420733B (sv) 1974-05-30 1981-10-26 Exploaterings Ab Tbf Gelprodukt, innehallande tiosulfatgrupper samt sett for framstellning derav
US3966580A (en) 1974-09-16 1976-06-29 The University Of Utah Novel protein-immobilizing hydrophobic polymeric membrane, process for producing same and apparatus employing same
SE430062B (sv) 1977-03-04 1983-10-17 Pharmacia Fine Chemicals Ab Kopplings- eller tioleringsreagens
DE2850058A1 (de) 1978-11-18 1980-05-29 Bayer Ag Polyaether-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4259474A (en) 1979-09-25 1981-03-31 Gaf Corporation Sulfur-containing polyoxyalkylenes
SE8102194L (sv) 1981-04-06 1982-10-07 Pharmacia Ab Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
DE3532593A1 (de) 1985-09-12 1987-03-12 Koemmerling Kunststoff Extrudierter kunststoffhohlprofilstab fuer rahmen von fenstern und tueren
DE3532626A1 (de) 1985-09-12 1987-03-19 Boehringer Mannheim Gmbh Verfahren zur bestimmung eines partners einer immunreaktion
WO1987006007A1 (fr) 1986-03-28 1987-10-09 Toray Industries, Inc. Substance physiologiquement active immobilisee
US5567859A (en) 1991-03-19 1996-10-22 Cytrx Corporation Polyoxypropylene/polyoxyethylene copolymers with improved biological activity
US5674911A (en) 1987-02-20 1997-10-07 Cytrx Corporation Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use
US5006333A (en) 1987-08-03 1991-04-09 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
IE64284B1 (en) 1987-08-03 1995-07-26 Ddi Pharmaceuticals Conjugates of superoxide dismutase
US4929510A (en) 1988-04-29 1990-05-29 State University Of New York Biocompatible polymer articles
US5248820A (en) 1989-02-21 1993-09-28 Pfizer Inc. Crystalline N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor
CA2028804C (en) 1989-11-21 2000-06-20 Howard J. Buttery Biomosaic polymers and method for preparing same
US5219926A (en) 1989-12-29 1993-06-15 Berol Nobel Ab Method of covalently bonding biopolymer to a solid hydrophilic organic polymer
CA2101918A1 (en) 1991-03-18 1992-09-19 Samuel Zalipsky Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
US5516703A (en) * 1993-08-20 1996-05-14 The University Of Utah Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands
US6284503B1 (en) 1993-08-20 2001-09-04 University Of Utah Research Foundation Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces
BE1008955A3 (fr) 1994-11-14 1996-10-01 Univ Catholique Louvain Procede d'obtention de biomateriaux et produits obtenus.
US5783178A (en) 1994-11-18 1998-07-21 Supratek Pharma. Inc. Polymer linked biological agents
US5565188A (en) 1995-02-24 1996-10-15 Nanosystems L.L.C. Polyalkylene block copolymers as surface modifiers for nanoparticles

Also Published As

Publication number Publication date
CA2277995C (en) 2003-03-18
AU6018298A (en) 1998-08-07
US20020019037A1 (en) 2002-02-14
KR20000070229A (ko) 2000-11-25
US6670199B2 (en) 2003-12-30
IL130961A (en) 2009-02-11
ATE501249T1 (de) 2011-03-15
EP1002066B1 (de) 2011-03-09
EP1002066A4 (de) 2004-12-01
EP1002066A1 (de) 2000-05-24
CA2277995A1 (en) 1998-07-23
JP2001512565A (ja) 2001-08-21
IL130961A0 (en) 2001-01-28
US6284503B1 (en) 2001-09-04
WO1998031734A1 (en) 1998-07-23
AU740877B2 (en) 2001-11-15
US7208299B2 (en) 2007-04-24
US20040170964A1 (en) 2004-09-02

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