ES2094287T3 - Composicion para inducir anergia humoral contra un inmunogeno. - Google Patents
Composicion para inducir anergia humoral contra un inmunogeno.Info
- Publication number
- ES2094287T3 ES2094287T3 ES92301036T ES92301036T ES2094287T3 ES 2094287 T3 ES2094287 T3 ES 2094287T3 ES 92301036 T ES92301036 T ES 92301036T ES 92301036 T ES92301036 T ES 92301036T ES 2094287 T3 ES2094287 T3 ES 2094287T3
- Authority
- ES
- Spain
- Prior art keywords
- immunogen
- composition
- induce humoral
- humoral anergy
- immunogens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE DESCRIBEN CONJUGADAS DE POLIMEROS INMUNOGENICOS ESTABLES Y ANALOGOS DE INMUNOGENES QUE POSEEN LA CAPACIDAD ESPECIFICA DE ENLACE DE CELULAS B DEL INMUNOGEN PERO CARECEN DE EPITOPES DE CELULA T Y QUE, CUANDO SE INTRODUCEN EN INDIVIDUOS, INDUCEN ENERGIA HUMORAL AL INMUNOGEN. DE ACUERDO CON ESTO, ESTOS CONJUGADOS SON UTILES PARA EL TRATAMIENTO DE PATOLOGIAS MEDIANTE ANTICUERPOS QUE SON CAUSADAS POR INMUNOGENES EXTERIORES O PROPIOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/652,648 US5268454A (en) | 1991-02-08 | 1991-02-08 | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2094287T3 true ES2094287T3 (es) | 1997-01-16 |
Family
ID=24617613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92301036T Expired - Lifetime ES2094287T3 (es) | 1991-02-08 | 1992-02-07 | Composicion para inducir anergia humoral contra un inmunogeno. |
Country Status (13)
Country | Link |
---|---|
US (5) | US5268454A (es) |
EP (1) | EP0498658B1 (es) |
JP (1) | JP2544873B2 (es) |
KR (1) | KR100234678B1 (es) |
AT (1) | ATE142109T1 (es) |
AU (1) | AU646157B2 (es) |
CA (1) | CA2076648C (es) |
DE (1) | DE69213272T2 (es) |
DK (1) | DK0498658T3 (es) |
ES (1) | ES2094287T3 (es) |
GR (1) | GR3021809T3 (es) |
IE (1) | IE920419A1 (es) |
WO (1) | WO1992013558A1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022544A (en) * | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
AU3423293A (en) * | 1991-12-19 | 1993-07-19 | Baylor College Of Medicine | Pva or peg conjugates of peptides for epitope-specific immunosuppression |
DE4302012C1 (de) * | 1993-01-26 | 1994-07-21 | Serosearch Gmbh Entwicklung Un | Immunologischer Test |
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US6410775B1 (en) | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US5817752A (en) * | 1996-06-06 | 1998-10-06 | La Jolla Pharmaceutical Company | Cyclic polypeptides comprising a thioether linkage and methods for their preparation |
EP0954531A1 (en) * | 1996-06-06 | 1999-11-10 | Lajolla Pharmaceutical Company | aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES |
US6936249B1 (en) * | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
CA2326618A1 (en) * | 1998-04-15 | 1999-10-21 | Baxter International Inc. | Inhibition of xenoreactive antibodies |
EP1073459A4 (en) * | 1998-04-27 | 2005-01-19 | Biocrystal Ltd | COMPOSITIONS AND METHODS OF TOLERATING IN IMMUNOMOPLEX-MEDIATED ILLNESS |
US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
DE69928995T2 (de) * | 1998-06-22 | 2006-09-07 | Affymetrix, Inc., Santa Clara | Reagenz und Verfahren zu fester Phase Synthese |
US6399578B1 (en) * | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
US20010010818A1 (en) * | 1998-12-09 | 2001-08-02 | Engle Steven B. | Methods and formulations for reducing circulating antibodies |
US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
CA2376057A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
MXPA02005236A (es) * | 1999-11-28 | 2004-03-19 | Jolla Pharma | Metodos de tratamiento de lupus con base en la afinidad de anticuerpos y metodos de separacion por exclusion y composiciones para el uso de los mismos. |
AU2001268228A1 (en) | 2000-06-08 | 2001-12-17 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
AU2001296305B2 (en) | 2000-09-26 | 2007-12-06 | Duke University | RNA aptamers and methods for identifying the same |
SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
CN1511041A (zh) * | 2001-05-17 | 2004-07-07 | ������ҩ������˾ | 利用抑制cd21的药剂治疗抗体介导的病变的方法 |
PT2070939E (pt) * | 2001-05-25 | 2014-06-09 | Univ Duke | Moduladores de agentes farmacológicos |
US20030114405A1 (en) * | 2001-08-13 | 2003-06-19 | Linnik Matthew D. | Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function |
US7105135B2 (en) * | 2001-10-16 | 2006-09-12 | Lockheed Martin Corporation | System and method for large scale detection of hazardous materials in the mail or in other objects |
AU2003303524A1 (en) * | 2002-12-27 | 2004-07-29 | La Jolla Pharmaceutical Company | Methods of improving health-related quality of life in individuals with systemic lupus erythematosus |
EP1613263A4 (en) * | 2003-01-31 | 2007-11-28 | Pathologica Llc | MONITORING AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS |
WO2004089422A2 (en) * | 2003-03-30 | 2004-10-21 | La Jolla Pharmaceutical Co. | Methods of treating and monitoring systemic lupus erythematosus in individuals |
AU2004227852B2 (en) * | 2003-03-31 | 2010-01-14 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
DE602004009818T2 (de) * | 2003-11-05 | 2008-09-18 | Intercell Ag | Zusammensetzungen, die von melittin abgeleitet sind und peptide enthalten, und verfahren zur potenzierung von immunreaktionen gegen target-antigene |
PL1745062T3 (pl) | 2004-04-22 | 2014-10-31 | Regado Biosciences Inc | Ulepszone modulatory czynników krzepnięcia |
ITPD20040159A1 (it) * | 2004-06-21 | 2004-09-21 | Univ Degli Studi Trieste | Derivati bifunzionali del polietilenglicole loro preparazione e uso. |
US8206726B2 (en) | 2006-02-06 | 2012-06-26 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
EP2057998A1 (en) * | 2007-10-31 | 2009-05-13 | Universitätsklinikum Hamburg-Eppendorf | Use of modified cells for the treatment of multiple sclerosis |
EP2731617A4 (en) | 2011-07-12 | 2015-07-01 | Brigham & Womens Hospital | LIPID-CONTAINING PSA COMPOSITIONS, METHODS OF ISOLATION AND METHODS OF USING SAME |
US10857177B2 (en) | 2015-08-19 | 2020-12-08 | President And Fellows Of Harvard College | Lipidated PSA compositions and methods |
US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
US10864279B2 (en) * | 2016-12-16 | 2020-12-15 | Industrial Technology Research Institute | Linker-drug and antibody-drug conjugate (ADC) employing the same |
EP3715374A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
EP3715375A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of pre-eclampsia |
US11986536B2 (en) | 2019-03-23 | 2024-05-21 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
EP3715376A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of myasthenia gravis |
AU2021347581A1 (en) | 2020-09-23 | 2023-05-18 | Ablevia Biotech Gmbh | Compound for the prevention or treatment of autoantibody-mediated conditions |
EP4216990A1 (en) | 2020-09-23 | 2023-08-02 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
TW202228784A (zh) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | 用以於一患者中螯合非預期的抗peg抗體的化合物 |
MX2023003375A (es) | 2020-09-23 | 2023-03-31 | Ablevia Biotech Gmbh | Compuesto para aumentar la eficacia de la terapia de sustitucion del factor viii. |
AU2021347583A1 (en) | 2020-09-23 | 2023-05-25 | Ablevia Biotech Gmbh | Compound for increasing efficacy of viral vectors |
JP2023543444A (ja) | 2020-09-24 | 2023-10-16 | アブレヴィア バイオテック ゲーエムベーハー | 重症筋無力症の予防又は治療のための化合物 |
WO2023180502A1 (en) | 2022-03-24 | 2023-09-28 | Ablevia Biotech Gmbh | Compound for increasing efficacy of oncolytic viruses |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US107389A (en) * | 1870-09-13 | Improved hat and cap-bracket | ||
US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
US162953A (en) * | 1875-05-04 | Improvement in fire-alarm telegraphs | ||
US26856A (en) * | 1860-01-17 | Btjoying ships | ||
US4351A (en) * | 1846-01-07 | Straw-cutter | ||
US2005A (en) * | 1841-03-16 | Improvement in the manner of constructing molds for casting butt-hinges | ||
US103990A (en) * | 1870-06-07 | Improvement in liquid-meters | ||
US82400A (en) * | 1868-09-22 | Improvement in kossfflg-maoeines | ||
US31635A (en) * | 1861-03-05 | Straw-cutter | ||
US4388441A (en) * | 1977-02-03 | 1983-06-14 | Scripps Clinic & Research Foundation | Induction of immunological tolerance |
US4191668A (en) * | 1977-02-03 | 1980-03-04 | Scripps Clinic And Research Foundation | Induction of immunological tolerance |
US4220565A (en) * | 1979-01-18 | 1980-09-02 | Scripps Clinic & Research Foundation | Immunochemical conjugates: method and composition |
US4430260A (en) * | 1979-02-27 | 1984-02-07 | Lee Weng Y | Penicillin-polyvinyl alcohol conjugate and process of preparation |
JPS56145222A (en) * | 1980-04-28 | 1981-11-11 | Toshiyuki Hamaoka | Improved antibody and its preparation |
GB2102825A (en) | 1981-07-31 | 1983-02-09 | Ici Plc | Polymer-modified polyols |
US5126131A (en) * | 1983-01-24 | 1992-06-30 | The Johns Hopkins University | Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates. |
US6022544A (en) * | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
US4650675A (en) * | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
US4599231A (en) * | 1984-03-09 | 1986-07-08 | Scripps Clinic And Research Foundation | Synthetic hepatitis B virus vaccine including both T cell and B cell determinants |
CH668554A5 (de) * | 1984-04-09 | 1989-01-13 | Sandoz Ag | Liposomen welche polypeptide mit interleukin-2-aktivitaet enthalten sowie verfahren zu ihrer herstellung. |
GB8411550D0 (en) * | 1984-05-04 | 1984-06-13 | Stylo Matchmakers Int | Injection moulding apparatus |
US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
US4950713A (en) * | 1986-05-30 | 1990-08-21 | La Jolla Pharmaceutical Company | Conjugates of D-glutamic acid: D-lysine copolymer and certain biochemicals |
US5017648A (en) * | 1986-05-30 | 1991-05-21 | La Jolla Pharmaceutical Company | D-GL conjugate therapy |
US4950469A (en) * | 1986-05-30 | 1990-08-21 | La Jolla Pharmaceutical Company | D-GL conjugate therapy |
US4886782A (en) * | 1987-02-26 | 1989-12-12 | The United States Of America As Represented By The Department Of Health And Human Services | Malarial immunogen |
JPS6468398A (en) * | 1987-09-08 | 1989-03-14 | Agency Ind Science Techn | Monoclonal anti-idiotype antibody and hybridoma and use thereof |
USD321129S (en) | 1988-06-28 | 1991-10-29 | Henkel Kommanditgesellschaft Auf Aktien | Container for dispensing liquid detergent or similar article |
US5102663A (en) * | 1988-10-18 | 1992-04-07 | Sloan-Kettering Instutute For Cancer Research | Vaccine for stimulating or enhancing production of antibodies against 9-O-acetyl GD3 |
DE473721T1 (de) * | 1989-05-25 | 1993-04-29 | Sloan-Kettering Institute For Cancer Research, New York, N.Y., Us | Antiidiotypischer antikoerper, der eine immunantwort gegen ein glykosphingolipid induziert und seine verwendung. |
JP2704779B2 (ja) * | 1989-12-15 | 1998-01-26 | 本田技研工業株式会社 | 加速度検知装置 |
US5162515A (en) | 1990-01-16 | 1992-11-10 | La Jolla Pharmaceutical Company | Conjugates of biologically stable polymers and polynucleotides for treating systemic lupus erythematosus |
US5268454A (en) | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
US5552391A (en) | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
DE69127470T2 (de) * | 1990-03-02 | 1998-02-19 | Autoimmune Inc | Verstärkung der unterdrückungsregulation von autoimmunkrankheiten durch orale oder enterale verabreichung von autoantigenen |
US5177188A (en) * | 1990-12-03 | 1993-01-05 | The Scripps Research Institute | Methods and compositions for diagnosing chronic immune thrombocytopenic purpura |
CA2098281A1 (en) * | 1990-12-17 | 1992-06-18 | Howard M. Dintzis | Suppression of immune responses of oligomeric forms of antigen of controlled chemistry |
ATE129900T1 (de) * | 1990-12-19 | 1995-11-15 | Schering Corp | Anwendung von il-4 zur steigerung der immunantwort auf immunogene in impfstoffen. |
AU664184B2 (en) | 1991-07-15 | 1995-11-09 | La Jolla Pharmaceutical Company | Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides |
US5736146A (en) * | 1992-07-30 | 1998-04-07 | Yeda Research And Development Co. Ltd. | Conjugates of poorly immunogenic antigens and synthetic peptide carriers and vaccines comprising them |
US5718352A (en) | 1994-11-22 | 1998-02-17 | Aluminum Company Of America | Threaded aluminum cans and methods of manufacture |
US5778723A (en) | 1992-07-31 | 1998-07-14 | Aluminum Company Of America | Method and apparatus for necking a metal container and resultant container |
KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US6410775B1 (en) | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
US6138847A (en) | 1999-02-25 | 2000-10-31 | Johnson; Russell Joe | Disposable non-reusable baby bottle |
USD424444S (en) | 1999-05-27 | 2000-05-09 | Mott's Inc. | Combined bottle and cap |
WO2006003368A2 (en) | 2004-07-01 | 2006-01-12 | The University Court Of The University Of Edinburgh | Improved c-element and logic reduction and completion detection circuits |
-
1991
- 1991-02-08 US US07/652,648 patent/US5268454A/en not_active Expired - Lifetime
-
1992
- 1992-02-04 AU AU14118/92A patent/AU646157B2/en not_active Ceased
- 1992-02-04 CA CA002076648A patent/CA2076648C/en not_active Expired - Fee Related
- 1992-02-04 KR KR1019920702481A patent/KR100234678B1/ko not_active IP Right Cessation
- 1992-02-04 JP JP4505775A patent/JP2544873B2/ja not_active Expired - Fee Related
- 1992-02-04 WO PCT/US1992/000975 patent/WO1992013558A1/en active Application Filing
- 1992-02-07 DK DK92301036.7T patent/DK0498658T3/da active
- 1992-02-07 IE IE041992A patent/IE920419A1/en not_active IP Right Cessation
- 1992-02-07 EP EP92301036A patent/EP0498658B1/en not_active Expired - Lifetime
- 1992-02-07 AT AT92301036T patent/ATE142109T1/de not_active IP Right Cessation
- 1992-02-07 ES ES92301036T patent/ES2094287T3/es not_active Expired - Lifetime
- 1992-02-07 DE DE69213272T patent/DE69213272T2/de not_active Expired - Fee Related
-
1993
- 1993-09-08 US US08/118,055 patent/US6060056A/en not_active Expired - Fee Related
-
1996
- 1996-11-28 GR GR960403200T patent/GR3021809T3/el unknown
-
2002
- 2002-02-20 US US10/081,076 patent/US7208156B2/en not_active Expired - Fee Related
-
2004
- 2004-07-16 US US10/892,956 patent/US7163683B2/en not_active Expired - Fee Related
- 2004-10-01 US US10/957,198 patent/US7138244B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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US5268454A (en) | 1993-12-07 |
GR3021809T3 (en) | 1997-02-28 |
WO1992013558A1 (en) | 1992-08-20 |
US20050170436A1 (en) | 2005-08-04 |
US6060056A (en) | 2000-05-09 |
KR100234678B1 (ko) | 1999-12-15 |
US7138244B2 (en) | 2006-11-21 |
JP2544873B2 (ja) | 1996-10-16 |
ATE142109T1 (de) | 1996-09-15 |
JPH05508421A (ja) | 1993-11-25 |
IE920419A1 (en) | 1992-08-12 |
US20050031635A1 (en) | 2005-02-10 |
CA2076648A1 (en) | 1992-08-09 |
EP0498658B1 (en) | 1996-09-04 |
US7208156B2 (en) | 2007-04-24 |
DE69213272T2 (de) | 1997-01-30 |
US20030103990A1 (en) | 2003-06-05 |
US7163683B2 (en) | 2007-01-16 |
EP0498658A2 (en) | 1992-08-12 |
AU1411892A (en) | 1992-09-07 |
EP0498658A3 (en) | 1993-05-12 |
DK0498658T3 (es) | 1997-02-17 |
CA2076648C (en) | 1999-08-17 |
AU646157B2 (en) | 1994-02-10 |
DE69213272D1 (de) | 1996-10-10 |
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