CA2277724A1 - A composition for inducing humoral anergy to an immunogen - Google Patents

A composition for inducing humoral anergy to an immunogen Download PDF

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Publication number
CA2277724A1
CA2277724A1 CA002277724A CA2277724A CA2277724A1 CA 2277724 A1 CA2277724 A1 CA 2277724A1 CA 002277724 A CA002277724 A CA 002277724A CA 2277724 A CA2277724 A CA 2277724A CA 2277724 A1 CA2277724 A1 CA 2277724A1
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CA
Canada
Prior art keywords
immunogen
composition
inducing humoral
immunogens
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002277724A
Other languages
French (fr)
Other versions
CA2277724C (en
Inventor
Paul Arylin Barstad
Gilbert Michael Iverson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
La Jolla Pharmaceutical Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/652,648 external-priority patent/US5268454A/en
Application filed by Individual filed Critical Individual
Publication of CA2277724A1 publication Critical patent/CA2277724A1/en
Application granted granted Critical
Publication of CA2277724C publication Critical patent/CA2277724C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Conjugates of stable nonimmunogenic polymers and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
CA002277724A 1991-02-08 1992-02-04 A composition for inducing humoral anergy to an immunogen Expired - Fee Related CA2277724C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US652,648 1991-02-08
US07/652,648 US5268454A (en) 1991-02-08 1991-02-08 Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
CA002076648A CA2076648C (en) 1991-02-08 1992-02-04 Composition for inducing humoral anergy to an immunogen

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002076648A Division CA2076648C (en) 1991-02-08 1992-02-04 Composition for inducing humoral anergy to an immunogen

Publications (2)

Publication Number Publication Date
CA2277724A1 true CA2277724A1 (en) 1992-08-09
CA2277724C CA2277724C (en) 2003-05-27

Family

ID=25675458

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002277724A Expired - Fee Related CA2277724C (en) 1991-02-08 1992-02-04 A composition for inducing humoral anergy to an immunogen

Country Status (1)

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CA (1) CA2277724C (en)

Also Published As

Publication number Publication date
CA2277724C (en) 2003-05-27

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