ES2094023T3 - Compuestos de vitamina d y metodo para preparar estos compuestos. - Google Patents

Compuestos de vitamina d y metodo para preparar estos compuestos.

Info

Publication number
ES2094023T3
ES2094023T3 ES94201403T ES94201403T ES2094023T3 ES 2094023 T3 ES2094023 T3 ES 2094023T3 ES 94201403 T ES94201403 T ES 94201403T ES 94201403 T ES94201403 T ES 94201403T ES 2094023 T3 ES2094023 T3 ES 2094023T3
Authority
ES
Spain
Prior art keywords
group
compounds
preparing
hydroxy
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94201403T
Other languages
English (en)
Inventor
Jose P Sestelo
Antonio Mourino
Jose L Mascarenas
Sebastianus J Halkes
Jan Zorgdrager
Gerhardus D H Dijkstra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22098649&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2094023(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Application granted granted Critical
Publication of ES2094023T3 publication Critical patent/ES2094023T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/457—Saturated compounds containing a keto group being part of a ring containing halogen
    • C07C49/467—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic
    • C07C49/473—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system
    • C07C49/477—Saturated compounds containing a keto group being part of a ring containing halogen polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/507—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic
    • C07C49/513—Saturated compounds containing a keto group being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system

Abstract

LA INVENCION SE REFIERE A UN NUEVO COMPUESTO DE VITAMINA D DE LA FORMULA GENERAL (I) EN LA QUE R2 ES UN GRUPO DE ALQUILO C1-C3, UN GRUPO DE HIDROXIALQUILO C1-C3, UN GRUPO DE ALCOXIMETILO C1-C2 O UN GRUPO DE ALQUENILO C2-C3 O DE ALQUINILO; R3 ES UN HIDROCARBONO DE ENTRE 3 Y 5 MIEMBROS SATURADO O INSATURADO, RAMIFICADO O NO RAMIFICADO O UN BI-RADICAL DE OXAHIDROCARBONO, QUE TIENE AL MENOS TRES ATOMOS EN LA CADENA PRINCIPAL Y QUE ESTA OPCIONALMENTE SUSTITUIDO CON UNO O MAS SUSTITUYENTES SELECCIONADOS ENTRE EPOXIDO, FLUOR E HIDROXIDO; IPRES UN GRUPO DE ISOPROPIL; Y A Y B SON CADA UNA INDIVIDUALMENTE ATOMOS DE HIDROGENO O GRUPOS DE METILO, O A Y B FORMAN JUNTAS UN GRUPO DE METILENO. LA INVENCION TAMBIEN SE REFIERE A UN METODO PARA PREPARAR ESTOS COMPUESTOS Y A SU USO EN LA FARMACOTERAPIA Y EN LA COSMETICA.
ES94201403T 1993-06-04 1994-05-18 Compuestos de vitamina d y metodo para preparar estos compuestos. Expired - Lifetime ES2094023T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/070,998 US5449668A (en) 1993-06-04 1993-06-04 Vitamin D compounds and method of preparing these compounds

Publications (1)

Publication Number Publication Date
ES2094023T3 true ES2094023T3 (es) 1997-01-01

Family

ID=22098649

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94201403T Expired - Lifetime ES2094023T3 (es) 1993-06-04 1994-05-18 Compuestos de vitamina d y metodo para preparar estos compuestos.

Country Status (15)

Country Link
US (3) US5449668A (es)
EP (1) EP0633245B1 (es)
KR (1) KR100301876B1 (es)
CN (1) CN1050829C (es)
AT (1) ATE142198T1 (es)
AU (1) AU679221B2 (es)
DE (1) DE69400469T2 (es)
DK (1) DK0633245T3 (es)
ES (1) ES2094023T3 (es)
GR (1) GR3021581T3 (es)
HU (1) HU219593B (es)
IL (1) IL109848A (es)
NZ (1) NZ260647A (es)
PL (1) PL179104B1 (es)
ZA (1) ZA943830B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2396524A1 (es) * 2012-12-11 2013-02-22 Universidade De Santiago De Compostela Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de vitamina D

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CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
ES2093180T3 (es) * 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
US6291444B1 (en) * 1993-06-16 2001-09-18 Wisconsin Alumni Research Foundation Treatment of t-cell immunodeficiencies with vitamin D compounds
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
US5552392A (en) * 1993-11-03 1996-09-03 Wisconsin Alumni Research Foundation Method of treating hypoparathyroidism with (20S) vitamin D compounds
US5502050A (en) * 1993-11-29 1996-03-26 Cornell Research Foundation, Inc. Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis
ATE176462T1 (de) * 1994-11-21 1999-02-15 Wisconsin Alumni Res Found 18,19-dinor-vitamin-d-derivate
US5661140A (en) * 1994-11-21 1997-08-26 Wisconsin Alumni Research Foundation 18-nor-vitamin D compounds
US20040043971A1 (en) * 1995-04-03 2004-03-04 Bone Care International, Inc. Method of treating and preventing hyperparathyroidism with active vitamin D analogs
US20020183288A1 (en) * 1995-04-03 2002-12-05 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
CA2175881A1 (en) * 1995-05-09 1996-11-10 Andrzej Kutner Vitamin d compounds and methods of preparing these compounds
EP0862916B1 (en) * 1995-11-20 2003-03-05 Kiyoshi Kita topical use of vitamin D for the treatment of eye disorders
US5939408A (en) 1996-05-23 1999-08-17 Hoffman-La Roche Inc. Vitamin D3 analogs
GB9622590D0 (en) 1996-10-30 1997-01-08 Leo Pharm Prod Ltd Chemical compounds
US6187331B1 (en) 1997-06-10 2001-02-13 New Vision Co., Ltd. Composition for prophylaxis and/or treatment of dry syndrome comprising vitamin D
US5939406A (en) * 1997-07-21 1999-08-17 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
US6359152B2 (en) 1997-07-21 2002-03-19 Wisconsin Alumni Research Foundation 18-substituted-19-nor-vitamin D compounds
EP0927721A1 (de) * 1997-12-17 1999-07-07 Schering Aktiengesellschaft Neue Vitamin D-Derivate mit Phosphoratomen in den Seitenketten, Zwischenprodukte bei ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
EP1042335A1 (de) 1997-12-17 2000-10-11 Schering Aktiengesellschaft Vitamin d-derivate mit phosphoratomen in den seitenketten
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
AU751240B2 (en) * 1998-07-10 2002-08-08 Duke University Therapies using hemoproteins
AU2942100A (en) * 1999-03-11 2000-09-28 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
US6912420B2 (en) * 2001-04-10 2005-06-28 Cardiac Pacemakers, Inc. Cardiac rhythm management system for hypotension
US7191000B2 (en) * 2001-07-31 2007-03-13 Cardiac Pacemakers, Inc. Cardiac rhythm management system for edema
WO2003026445A1 (en) * 2001-09-27 2003-04-03 The Coca-Cola Company Vitamin fortification of foodstuffs
US8034831B2 (en) * 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) * 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US20060171983A1 (en) * 2003-07-30 2006-08-03 Jin Tian Use of Vitamin D receptor activators or Vitamin D analogs to treat cardiovascular disease
WO2005027930A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. 2-alkylene-19-nor-vitamin d derivatives for the treatment of osteosarcoma
BRPI0507318A (pt) * 2004-03-18 2007-06-26 Leo Pharma As métodos para reduzir um composto, para a produção de calcipotriol ou monoidrato de calcipotriol, e de um composto, e de reação da mistura de compostos, composto, e, uso de um composto
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
US7387610B2 (en) 2004-08-19 2008-06-17 Cardiac Pacemakers, Inc. Thoracic impedance detection with blood resistivity compensation
WO2006094064A2 (en) * 2005-02-28 2006-09-08 Avocet Polymer Technologies, Inc. Method of reducing scars with vitamin d
US7603170B2 (en) * 2005-04-26 2009-10-13 Cardiac Pacemakers, Inc. Calibration of impedance monitoring of respiratory volumes using thoracic D.C. impedance
US7907997B2 (en) 2005-05-11 2011-03-15 Cardiac Pacemakers, Inc. Enhancements to the detection of pulmonary edema when using transthoracic impedance
US7340296B2 (en) 2005-05-18 2008-03-04 Cardiac Pacemakers, Inc. Detection of pleural effusion using transthoracic impedance
KR20170096238A (ko) * 2009-01-27 2017-08-23 베르그 엘엘씨 화학요법과 연관된 부작용을 경감시키기 위한 비타민 ｄ３ 및 이의 유사물
JP5978130B2 (ja) 2009-08-14 2016-08-24 バーグ エルエルシー 脱毛症を治療するためのビタミンｄ３およびその類似体
EP3003497B1 (en) 2013-05-29 2024-02-14 BPGbio, Inc. Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN105481256B (zh) * 2015-12-30 2018-02-16 三川德青科技有限公司 一种铅锌浮选尾矿微晶玻璃及其制备方法

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AU603340B2 (en) * 1985-08-02 1990-11-15 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
JP2711161B2 (ja) * 1988-04-21 1998-02-10 レオ・ファーマシューティカル・プロダクツ・リミテッド・エイ／エス（レーベンス・ケミスケ・ファブリック・プロデュクチオンスアクチーセルスカブ） 新規ビタミンｄ類似体
US5401732A (en) * 1989-02-23 1995-03-28 Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab Vitamin D analogues
US5378695A (en) * 1989-02-23 1995-01-03 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Vitamin D analogues
GB8904154D0 (en) * 1989-02-23 1989-04-05 Leo Pharm Prod Ltd Chemical compounds
US5321018A (en) * 1989-03-09 1994-06-14 Wisconsin Alumni Research Foundation Use of 1α-hydroxylated-19-nor-vitamin D compounds to treat psoriasis
NZ232734A (en) * 1989-03-09 1991-11-26 Wisconsin Alumni Res Found 19-nor vitamin d derivatives and pharmaceutical compositions
US5246925A (en) * 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB8915770D0 (en) * 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
US5459136A (en) * 1990-08-24 1995-10-17 Wisconsin Alumni Research Foundation Methods using vitamin D compounds for improvement of skin conditions
US5486509A (en) * 1991-06-28 1996-01-23 University Of Miami Method of preventing and treating chemotherapy-induced alopecia
ES2093180T3 (es) * 1991-07-05 1996-12-16 Duphar Int Res Compuesto de vitamina d, metodo de preparar este compuesto y producto intermedio de dicho metodo.
DE4220757A1 (de) * 1992-06-24 1994-01-05 Schering Ag Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2396524A1 (es) * 2012-12-11 2013-02-22 Universidade De Santiago De Compostela Intermedios versátiles y funcionalizados en la síntesis de vitamina D y nuevos derivados de vitamina D
WO2014091046A1 (es) * 2012-12-11 2014-06-19 Unversidade De Santiago De Compostela Intermedios versátiles y funcionalizados en la síntesis de vitamina d y nuevos derivados de vitamina d
US9994508B2 (en) 2012-12-11 2018-06-12 Endotherm Gmbh Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives

Also Published As

Publication number Publication date
ZA943830B (en) 1995-05-04
CN1099385A (zh) 1995-03-01
GR3021581T3 (en) 1997-02-28
KR950000662A (ko) 1995-01-03
EP0633245A1 (en) 1995-01-11
US5449668A (en) 1995-09-12
DK0633245T3 (da) 1996-12-23
DE69400469D1 (de) 1996-10-10
NZ260647A (en) 1995-11-27
PL179104B1 (pl) 2000-07-31
IL109848A (en) 1999-06-20
KR100301876B1 (ko) 2001-11-22
US6075015A (en) 2000-06-13
CN1050829C (zh) 2000-03-29
USRE36854E (en) 2000-09-05
HU219593B (hu) 2001-05-28
EP0633245B1 (en) 1996-09-04
AU6347294A (en) 1994-12-08
AU679221B2 (en) 1997-06-26
HU9401637D0 (en) 1994-08-29
IL109848A0 (en) 1994-10-07
PL303652A1 (en) 1994-12-12
DE69400469T2 (de) 1997-03-27
ATE142198T1 (de) 1996-09-15
HUT67928A (en) 1995-05-29

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