CA2097997A1 - Vitamin d compounds and method of preparing these compounds - Google Patents

Vitamin d compounds and method of preparing these compounds

Info

Publication number
CA2097997A1
CA2097997A1 CA002097997A CA2097997A CA2097997A1 CA 2097997 A1 CA2097997 A1 CA 2097997A1 CA 002097997 A CA002097997 A CA 002097997A CA 2097997 A CA2097997 A CA 2097997A CA 2097997 A1 CA2097997 A1 CA 2097997A1
Authority
CA
Canada
Prior art keywords
group
compounds
hydroxy
alkyl group
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002097997A
Other languages
French (fr)
Other versions
CA2097997C (en
Inventor
Jose P. Sestelo
Antonio Mourino
Jose Mascarenas
Sebastianus J. Halkes
Jan Zorgdrager
Gerhardus D.H. Dijkstra
Jan-Paul Van De Velde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar International Research BV filed Critical Duphar International Research BV
Priority to CA002097997A priority Critical patent/CA2097997C/en
Priority to JP18547893A priority patent/JP3633639B2/en
Publication of CA2097997A1 publication Critical patent/CA2097997A1/en
Application granted granted Critical
Publication of CA2097997C publication Critical patent/CA2097997C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to a new vitamin D compound of the general formula wherein:

R1 is a hydrogen atom or a hydroxy group;
R2 is a (C1-C3)alkyl group, a hydroxy(C1-C3)alkyl group, a (C1-C2) alkoxymethyl group or a (C2-C3) alkenyl or alkynyl group;
R3 is a branched or non-branched, saturated or unsaturated aliphatic 3- to 5-membered hydrocarbon or oxahydrocarbon biradical, having at least 3 atoms in the main chain and being optionally substituted with one or more substituents selected from epoxy, fluoro and hydroxy;

R4 is a sec. or tert. (C3-C6)alkyl group or a (C3-C6)cycloalkyl group; and A and B are each individually hydrogen atoms or methyl groups, or A and B form together a methylene group.

The invention further relates to a method of preparing these compounds and to their use in pharmacotherapy and cosmetics.
CA002097997A 1993-06-08 1993-06-08 Vitamin d compounds and method of preparing these compounds Expired - Fee Related CA2097997C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002097997A CA2097997C (en) 1993-06-08 1993-06-08 Vitamin d compounds and method of preparing these compounds
JP18547893A JP3633639B2 (en) 1993-06-08 1993-06-29 Vitamin D compounds and methods for producing them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002097997A CA2097997C (en) 1993-06-08 1993-06-08 Vitamin d compounds and method of preparing these compounds
JP18547893A JP3633639B2 (en) 1993-06-08 1993-06-29 Vitamin D compounds and methods for producing them

Publications (2)

Publication Number Publication Date
CA2097997A1 true CA2097997A1 (en) 1994-12-09
CA2097997C CA2097997C (en) 2006-01-10

Family

ID=25676261

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002097997A Expired - Fee Related CA2097997C (en) 1993-06-08 1993-06-08 Vitamin d compounds and method of preparing these compounds

Country Status (2)

Country Link
JP (1) JP3633639B2 (en)
CA (1) CA2097997C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710034B2 (en) 2000-04-04 2014-04-29 Color Access, Inc. Method and composition for improving skin barrier function

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710034B2 (en) 2000-04-04 2014-04-29 Color Access, Inc. Method and composition for improving skin barrier function

Also Published As

Publication number Publication date
JP3633639B2 (en) 2005-03-30
CA2097997C (en) 2006-01-10
JPH0717947A (en) 1995-01-20

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20090608