ES2090945T3 - Procedimiento para la preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta. - Google Patents

Procedimiento para la preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta.

Info

Publication number
ES2090945T3
ES2090945T3 ES93830506T ES93830506T ES2090945T3 ES 2090945 T3 ES2090945 T3 ES 2090945T3 ES 93830506 T ES93830506 T ES 93830506T ES 93830506 T ES93830506 T ES 93830506T ES 2090945 T3 ES2090945 T3 ES 2090945T3
Authority
ES
Spain
Prior art keywords
carnitine
procedure
preparation
waste product
opposing configuration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93830506T
Other languages
English (en)
Inventor
Fabio Giannessi
Maria Laura Bolognesi
Maria Ornella Tinti
Angelis Francesco De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2090945T3 publication Critical patent/ES2090945T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Processing Of Solid Wastes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA MANUFACTURAR L-(-)CARNITINA A PARTIR DE D-(-)-CARNITINA O DE UN DERIVADO DE LA MISMA. LA D-(-)-CARNITINA SE ESTERIFICA PARA PROTEGER EL GRUPO DE CARBOXIL Y SUBSECUENTEMENTE SE CONVIERTE EN UN DERIVADO DE AZILO. EL DERIVADO DE ACILO SE CONVIERTE ENTONCES EN UNA LACTONA DE L-(-)-CARNITINA. FINALMENTE, SE REABRE LA LACTONA PARA OBTENER L-(-)-CARNITINA.
ES93830506T 1992-12-21 1993-12-15 Procedimiento para la preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta. Expired - Lifetime ES2090945T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920915A IT1256705B (it) 1992-12-21 1992-12-21 Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Publications (1)

Publication Number Publication Date
ES2090945T3 true ES2090945T3 (es) 1996-10-16

Family

ID=11401346

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93830506T Expired - Lifetime ES2090945T3 (es) 1992-12-21 1993-12-15 Procedimiento para la preparacion de l-(-)-carnitina a partir de un producto de desecho que tiene configuracion opuesta.

Country Status (13)

Country Link
US (2) US5412113A (es)
EP (1) EP0609643B1 (es)
JP (1) JP3502649B2 (es)
KR (1) KR100294780B1 (es)
AT (1) ATE140694T1 (es)
CA (1) CA2111898C (es)
DE (1) DE69303807T2 (es)
DK (1) DK0609643T3 (es)
ES (1) ES2090945T3 (es)
GR (1) GR3020617T3 (es)
HK (1) HK1005861A1 (es)
IT (1) IT1256705B (es)
ZA (1) ZA939444B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1240760B (it) * 1990-02-12 1993-12-17 Sigma Tau Ind Farmaceuti Esteri di acil-l-carnitine con l'acido gamma-idrossibutirrico e composizioni farmaceutiche che li contengono per l'inibizione della degenerazione neuronale e nel trattamento del coma.
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
IT1299182B1 (it) 1998-05-29 2000-02-29 Sigma Tau Ind Farmaceuti Procedimento chimico per la sintesi stereoselettiva della r-(-)- carnitina.
IT1301977B1 (it) 1998-07-31 2000-07-20 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di r-(-)-carnitina
IT1307303B1 (it) 1999-12-23 2001-10-30 Sigma Tau Ind Farmaceuti Idrolisi stereospecifica di esteri otticamente attivi.
IT1306184B1 (it) * 1999-08-05 2001-05-30 Sigma Tau Ind Farmaceuti Nitrilossi derivati della (r) e (s)-carnitina.
KR100827900B1 (ko) * 1999-09-03 2008-05-07 시그마-타우 헬스사이언스 에스.피.에이 초미세 ｌ-카르니틴, 그의 제조 방법, 그를 함유하는조성물 및 그를 이용하는 방법
DE10027393B4 (de) * 2000-06-02 2007-05-16 Wella Ag Poly- und Oligoester kationischer Hydroxysäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
KR20130093078A (ko) * 2010-07-21 2013-08-21 론차리미티드 베타-락톤으로부터 카르니틴의 제조방법
EP3164125B8 (en) 2014-07-03 2023-10-18 Silti AG Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes
CN115057789B (zh) * 2022-06-30 2024-04-02 中科萱嘉医养(珠海)健康科技有限公司 一种左旋肉碱离子液体及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts

Also Published As

Publication number Publication date
DE69303807T2 (de) 1996-11-28
ITRM920915A1 (it) 1994-06-21
ITRM920915A0 (it) 1992-12-21
EP0609643A1 (en) 1994-08-10
KR940014303A (ko) 1994-07-18
JPH06199751A (ja) 1994-07-19
JP3502649B2 (ja) 2004-03-02
HK1005861A1 (en) 1999-01-29
DE69303807D1 (de) 1996-08-29
US5599978A (en) 1997-02-04
IT1256705B (it) 1995-12-12
ZA939444B (en) 1994-08-09
EP0609643B1 (en) 1996-07-24
CA2111898C (en) 2004-04-27
KR100294780B1 (ko) 2001-09-17
CA2111898A1 (en) 1994-06-22
US5412113A (en) 1995-05-02
GR3020617T3 (en) 1996-10-31
DK0609643T3 (da) 1996-11-11
ATE140694T1 (de) 1996-08-15

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