ES2089571T3 - 3-(n-isopropil-n-n-propilamino)-5-(n-isopropil)carbamoilcromano. - Google Patents
3-(n-isopropil-n-n-propilamino)-5-(n-isopropil)carbamoilcromano.Info
- Publication number
- ES2089571T3 ES2089571T3 ES92921525T ES92921525T ES2089571T3 ES 2089571 T3 ES2089571 T3 ES 2089571T3 ES 92921525 T ES92921525 T ES 92921525T ES 92921525 T ES92921525 T ES 92921525T ES 2089571 T3 ES2089571 T3 ES 2089571T3
- Authority
- ES
- Spain
- Prior art keywords
- isopropil
- treatment
- propilamino
- carbamoilcromano
- obses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
UN 3-(N-ISOPROPIL-N-N-PROPILAMINO)-5-(N-ISOPROPIL)CARBAMOILCROMANO TIENE LA FORMULA (I), COMO UN RACEMATO, (R)-ENANTIOMERO EN FORMA DE BASE LIBRE O SUS SALES FARMACEUTICAMENTE ACEPTABLES. EL OBJETO DE LA INVENCION ES OFRECER UNOS COMPUESTOS DE USO TERAPEUTICO, ESPECIALMENTE PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR 5HIDROXITRIPTAMINA EN EL SISTEMA NERVIOSO CENTRAL , POR EJEMPLO: DEPRESION, ANSIEDAD, ENFERMEDAD OBSESIVO COMPULSIVA (OCD), ANOREXIA, DEMENCIA SENIL, MIGRAÑA, ENFERMEDAD DE ALZHEIMER, HIPERTENSION, DESORDENES SEXUALES TERMOREGULADORES, DERRAME CEREBRAL, DOLORES Y TRATAMIENTO DE PROBLEMAS DEL SISTEMA CARDIOVASCULAR.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9102905A SE9102905D0 (sv) | 1991-10-08 | 1991-10-08 | A new therapeutically active compound and a process for its preparation |
SE9202000A SE9202000D0 (sv) | 1992-06-29 | 1992-06-29 | A new therapeutically active compound |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2089571T3 true ES2089571T3 (es) | 1996-10-01 |
Family
ID=26661197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92921525T Expired - Lifetime ES2089571T3 (es) | 1991-10-08 | 1992-10-08 | 3-(n-isopropil-n-n-propilamino)-5-(n-isopropil)carbamoilcromano. |
Country Status (32)
Country | Link |
---|---|
EP (3) | EP0703229A3 (es) |
JP (1) | JPH07500320A (es) |
CN (2) | CN1072411A (es) |
AP (1) | AP338A (es) |
AT (1) | ATE139774T1 (es) |
AU (1) | AU667687B2 (es) |
BG (1) | BG98684A (es) |
CA (1) | CA2118708A1 (es) |
CY (1) | CY1992A (es) |
CZ (1) | CZ51094A3 (es) |
DE (1) | DE69211857T2 (es) |
DK (1) | DK0607274T3 (es) |
EE (1) | EE02981B1 (es) |
ES (1) | ES2089571T3 (es) |
FI (1) | FI941616A0 (es) |
GR (1) | GR3020608T3 (es) |
HK (1) | HK55997A (es) |
HR (1) | HRP920935A2 (es) |
HU (1) | HUT68834A (es) |
IL (1) | IL103373A0 (es) |
IS (2) | IS1644B (es) |
MA (1) | MA22674A1 (es) |
MX (1) | MX9205744A (es) |
MY (1) | MY131174A (es) |
NO (1) | NO941256L (es) |
NZ (2) | NZ270595A (es) |
PL (1) | PL171013B1 (es) |
SI (1) | SI9200249A (es) |
SK (1) | SK36194A3 (es) |
TN (1) | TNSN92088A1 (es) |
WO (1) | WO1993007135A1 (es) |
YU (1) | YU90492A (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5420151A (en) * | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
CA2345079C (en) * | 1998-09-23 | 2011-06-21 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
US6235938B1 (en) * | 1999-06-10 | 2001-05-22 | Yale University | Transition metal-catalyzed process for preparing N-aryl amine compounds |
JP2019523279A (ja) | 2016-07-29 | 2019-08-22 | サノビオン ファーマシューティカルズ インクSunovion Pharmaceuticals Inc. | 化合物および組成物ならびにそれらの使用 |
CA3070993A1 (en) | 2017-08-02 | 2019-02-07 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0222996B1 (de) * | 1985-09-03 | 1991-05-22 | Ciba-Geigy Ag | 3-Amino-dihydro-[1]-benzopyrane und Benzothiopyrane |
US4801605A (en) * | 1986-08-29 | 1989-01-31 | Ciba-Geigy Corporation | 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans |
SE8605504D0 (sv) * | 1986-12-19 | 1986-12-19 | Astra Laekemedel Ab | Novel chroman derivatives |
JPH021429A (ja) * | 1988-06-09 | 1990-01-05 | Toray Ind Inc | 光学活性1−メチル−3−フェニルプロピルアミンの製造方法 |
SE8904361D0 (sv) * | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
-
1992
- 1992-10-02 HR HR920935A patent/HRP920935A2/hr not_active Application Discontinuation
- 1992-10-05 MY MYPI92001795A patent/MY131174A/en unknown
- 1992-10-05 NZ NZ270595A patent/NZ270595A/en unknown
- 1992-10-05 NZ NZ244618A patent/NZ244618A/en unknown
- 1992-10-07 IS IS3929A patent/IS1644B/is unknown
- 1992-10-07 MX MX9205744A patent/MX9205744A/es unknown
- 1992-10-07 MA MA22959A patent/MA22674A1/fr unknown
- 1992-10-08 CA CA002118708A patent/CA2118708A1/en not_active Abandoned
- 1992-10-08 DK DK92921525.9T patent/DK0607274T3/da active
- 1992-10-08 CN CN92112826A patent/CN1072411A/zh active Pending
- 1992-10-08 CZ CZ94510A patent/CZ51094A3/cs unknown
- 1992-10-08 ES ES92921525T patent/ES2089571T3/es not_active Expired - Lifetime
- 1992-10-08 JP JP5506849A patent/JPH07500320A/ja active Pending
- 1992-10-08 AP APAP/P/1992/000434A patent/AP338A/en active
- 1992-10-08 PL PL92303101A patent/PL171013B1/pl unknown
- 1992-10-08 AU AU27684/92A patent/AU667687B2/en not_active Ceased
- 1992-10-08 EP EP95118114A patent/EP0703229A3/en not_active Withdrawn
- 1992-10-08 DE DE69211857T patent/DE69211857T2/de not_active Expired - Fee Related
- 1992-10-08 HU HU9400993A patent/HUT68834A/hu unknown
- 1992-10-08 EP EP92850237A patent/EP0538222A1/en active Pending
- 1992-10-08 TN TNTNSN92088A patent/TNSN92088A1/fr unknown
- 1992-10-08 WO PCT/SE1992/000708 patent/WO1993007135A1/en not_active Application Discontinuation
- 1992-10-08 SK SK361-94A patent/SK36194A3/sk unknown
- 1992-10-08 EP EP92921525A patent/EP0607274B1/en not_active Expired - Lifetime
- 1992-10-08 SI SI19929200249A patent/SI9200249A/sl unknown
- 1992-10-08 IL IL103373A patent/IL103373A0/xx unknown
- 1992-10-08 AT AT92921525T patent/ATE139774T1/de not_active IP Right Cessation
- 1992-10-08 YU YU90492A patent/YU90492A/sh unknown
- 1992-12-08 IS IS4310A patent/IS4310A/is unknown
-
1994
- 1994-03-29 BG BG98684A patent/BG98684A/xx unknown
- 1994-04-07 NO NO941256A patent/NO941256L/no unknown
- 1994-04-08 FI FI941616A patent/FI941616A0/fi not_active Application Discontinuation
- 1994-11-23 EE EE9400368A patent/EE02981B1/xx unknown
-
1996
- 1996-02-28 CN CN96103466A patent/CN1146992A/zh active Pending
- 1996-07-23 GR GR960401967T patent/GR3020608T3/el unknown
-
1997
- 1997-05-01 HK HK55997A patent/HK55997A/xx not_active IP Right Cessation
- 1997-09-05 CY CY199297A patent/CY1992A/xx unknown
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