DE69211857D1 - 3-(N-ISOPROPYL-N-u-PROPYLAMINO)-5-(N-ISOPROPYL)CARBAMOYLCHROMAN - Google Patents

3-(N-ISOPROPYL-N-u-PROPYLAMINO)-5-(N-ISOPROPYL)CARBAMOYLCHROMAN

Info

Publication number
DE69211857D1
DE69211857D1 DE69211857T DE69211857T DE69211857D1 DE 69211857 D1 DE69211857 D1 DE 69211857D1 DE 69211857 T DE69211857 T DE 69211857T DE 69211857 T DE69211857 T DE 69211857T DE 69211857 D1 DE69211857 D1 DE 69211857D1
Authority
DE
Germany
Prior art keywords
isopropyl
carbamoylchroman
propylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69211857T
Other languages
English (en)
Other versions
DE69211857T2 (de
Inventor
Eva Maria Hammarberg
Lars Johansson
Svante Ross
Seth Thorberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9102905A external-priority patent/SE9102905D0/xx
Priority claimed from SE9202000A external-priority patent/SE9202000D0/xx
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE69211857D1 publication Critical patent/DE69211857D1/de
Publication of DE69211857T2 publication Critical patent/DE69211857T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D335/00Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06Benzothiopyrans; Hydrogenated benzothiopyrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69211857T 1991-10-08 1992-10-08 3-(N-ISOPROPYL-N-u-PROPYLAMINO)-5-(N-ISOPROPYL)CARBAMOYLCHROMAN Expired - Fee Related DE69211857T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9102905A SE9102905D0 (sv) 1991-10-08 1991-10-08 A new therapeutically active compound and a process for its preparation
SE9202000A SE9202000D0 (sv) 1992-06-29 1992-06-29 A new therapeutically active compound
PCT/SE1992/000708 WO1993007135A1 (en) 1991-10-08 1992-10-08 3-(n-isopropyl-n-n-propylamino)-5-(n-isopropyl)carbamoylchroman

Publications (2)

Publication Number Publication Date
DE69211857D1 true DE69211857D1 (de) 1996-08-01
DE69211857T2 DE69211857T2 (de) 1996-10-24

Family

ID=26661197

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69211857T Expired - Fee Related DE69211857T2 (de) 1991-10-08 1992-10-08 3-(N-ISOPROPYL-N-u-PROPYLAMINO)-5-(N-ISOPROPYL)CARBAMOYLCHROMAN

Country Status (32)

Country Link
EP (3) EP0703229A3 (de)
JP (1) JPH07500320A (de)
CN (2) CN1072411A (de)
AP (1) AP338A (de)
AT (1) ATE139774T1 (de)
AU (1) AU667687B2 (de)
BG (1) BG98684A (de)
CA (1) CA2118708A1 (de)
CY (1) CY1992A (de)
CZ (1) CZ51094A3 (de)
DE (1) DE69211857T2 (de)
DK (1) DK0607274T3 (de)
EE (1) EE02981B1 (de)
ES (1) ES2089571T3 (de)
FI (1) FI941616A (de)
GR (1) GR3020608T3 (de)
HK (1) HK55997A (de)
HR (1) HRP920935A2 (de)
HU (1) HUT68834A (de)
IL (1) IL103373A0 (de)
IS (2) IS1644B (de)
MA (1) MA22674A1 (de)
MX (1) MX9205744A (de)
MY (1) MY131174A (de)
NO (1) NO941256L (de)
NZ (2) NZ244618A (de)
PL (1) PL171013B1 (de)
SI (1) SI9200249A (de)
SK (1) SK36194A3 (de)
TN (1) TNSN92088A1 (de)
WO (1) WO1993007135A1 (de)
YU (1) YU90492A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420151A (en) * 1989-12-22 1995-05-30 Aktiebolaget Astra Chroman derivatives
US5990114A (en) * 1996-02-28 1999-11-23 Recordati, S.A., Chemical And Pharmaceutical Company Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
DE69942342D1 (de) * 1998-09-23 2010-06-17 Res Dev Foundation Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen
US6235938B1 (en) * 1999-06-10 2001-05-22 Yale University Transition metal-catalyzed process for preparing N-aryl amine compounds
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. ISOCHROMAN COMPOUNDS AND USES THEREOF

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR862239B (en) * 1985-09-03 1986-12-31 Ciba Geigy Ag 3-amino-dihydro-(1)-benzopyrans and benzothiopyrans
US4801605A (en) * 1986-08-29 1989-01-31 Ciba-Geigy Corporation 3-amino-dihydro-[1]-benzopyrans and benzothiopyrans
SE8605504D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel chroman derivatives
JPH021429A (ja) * 1988-06-09 1990-01-05 Toray Ind Inc 光学活性1−メチル−3−フェニルプロピルアミンの製造方法
SE8904361D0 (sv) * 1989-12-22 1989-12-22 Astra Ab New chroman and thiochroman derivatives

Also Published As

Publication number Publication date
ES2089571T3 (es) 1996-10-01
MX9205744A (es) 1993-04-01
MY131174A (en) 2007-07-31
CY1992A (en) 1997-09-05
IL103373A0 (en) 1993-03-15
WO1993007135A1 (en) 1993-04-15
CN1072411A (zh) 1993-05-26
AU2768492A (en) 1993-05-03
CZ51094A3 (en) 1994-11-16
AP9200434A0 (en) 1992-10-31
JPH07500320A (ja) 1995-01-12
DK0607274T3 (da) 1996-11-04
SI9200249A (en) 1993-06-30
EP0607274B1 (de) 1996-06-26
FI941616A0 (fi) 1994-04-08
EP0703229A2 (de) 1996-03-27
EE02981B1 (et) 1997-04-15
CN1146992A (zh) 1997-04-09
DE69211857T2 (de) 1996-10-24
HUT68834A (en) 1995-08-28
IS4310A (is) 1993-04-09
IS1644B (is) 1997-03-25
YU90492A (sh) 1995-12-04
NZ244618A (en) 1996-10-28
FI941616A (fi) 1994-04-08
BG98684A (en) 1995-05-31
NO941256D0 (no) 1994-04-07
EP0703229A3 (de) 1996-06-26
EP0538222A1 (de) 1993-04-21
HK55997A (en) 1997-05-09
PL171013B1 (pl) 1997-02-28
SK36194A3 (en) 1994-12-07
HRP920935A2 (en) 1995-08-31
NZ270595A (en) 1996-10-28
AP338A (en) 1994-04-26
NO941256L (no) 1994-04-07
AU667687B2 (en) 1996-04-04
EP0607274A1 (de) 1994-07-27
IS3929A (is) 1993-04-09
ATE139774T1 (de) 1996-07-15
CA2118708A1 (en) 1993-04-15
MA22674A1 (fr) 1993-07-01
TNSN92088A1 (fr) 1993-06-08
HU9400993D0 (en) 1994-08-29
GR3020608T3 (en) 1996-10-31

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee